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[1]李瑾综述,刘炯审校.活性氧与肿瘤关系的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2019,21(3):297-301.[doi:10.3969/j.issn.1672-271X.2019.03.016]
　LI Jin reviewing,LIU Jiong checking.Progress study of reactive oxygen species and tumor[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2019,21(3):297-301.[doi:10.3969/j.issn.1672-271X.2019.03.016]
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活性氧与肿瘤关系的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第21卷
期数:
2019年3期
页码:
297-301
栏目:
综述
出版日期:
2019-05-10

文章信息/Info

Title:
Progress study of reactive oxygen species and tumor
文章编号:
1672-271X（2019）03-0297-05
作者:
李瑾综述;  刘炯审校
作者单位：233033 蚌埠，蚌埠医学院（李 瑾）; 210002 南京，东部战区总医院（原南京军区南京总医院）消化内科（刘 炯）
Author(s):
LI Jin1 reviewing;  LIU Jiong2 checking
(1.Bengbu Medical College，Bengbu 233003，Anhui，China; 2.Department of Gastroenterology，General Hospital of Eastern Theater Command，PLA, Nanjing 210002，Jiangsu，China)
关键词:
活性氧;  肿瘤;  凋亡
Keywords:
reactive oxygen species;  tumor;  apoptosis
分类号:
R73
DOI:
10.3969/j.issn.1672-271X.2019.03.016
文献标志码:
A
摘要:
活性氧（ROS）主要是细胞线粒体电子传递链产生的一些性质活泼的含氧物质。肿瘤相关基因可能会诱导活性氧的产生，继而激活与肿瘤发生发展相关的信号通路。ROS因为浓度的不同，对细胞也具有不同的作用。肿瘤细胞出现原因是细胞在分裂、增殖的过程中基因发生突变，ROS则会促进这一过程。而细胞死亡的原因是ROS导致细胞DNA、蛋白质、脂质的损伤。文章主要从ROS的生成与清除、ROS的致癌作用、ROS的抑癌作用等方面进行综述。
Abstract:
Reactive oxygen species (ROS) is the general name for the active oxygen metabolites that the mainly production from electron transport chain. Tumor-associated genes may induce the production of ROS, which in turn activate the signal pathways involved in tumor development. ROS promotes cell mitosis and proliferation, increases genomic instability and induces tumorigenesis and development. However，the high concentration of ROS causes the damage of DNA, protein and lipid, eventually leading to cell death. This article reviews the generation and clearance, the carcinogenic effect, and the anti-cancer effect of ROS.

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备注/Memo

备注/Memo:
收稿日期：2018-10-19
更新日期/Last Update: 2019-05-10