|本期目录/Table of Contents|

[1]张亮,王斌综述,陈东风审校.线性泛素化修饰在肿瘤发生发展中的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2019,21(4):382-386.[doi:10.3969/j.issn.1672-271X.2019.04.011]
　ZHANG Liang,WANG Bin reviewing,CHEN Dong-feng checking.Research progress of linear ubiquitination in cancer[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2019,21(4):382-386.[doi:10.3969/j.issn.1672-271X.2019.04.011]
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线性泛素化修饰在肿瘤发生发展中的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第21卷
期数:
2019年4期
页码:
382-386
栏目:
综述
出版日期:
2019-07-20

文章信息/Info

Title:
Research progress of linear ubiquitination in cancer
文章编号:
1672-271X（2019）04-0382-05
作者:
张亮;  王斌综述;  陈东风审校
作者单位：400042 重庆，陆军军医大学大坪医院消化内科（张 亮、王 斌、陈东风）
Author(s):
ZHANG Liang;  WANG Bin reviewing;  CHEN Dong-feng checking
(Department of Gastroenterology, Daping Hospital, Army Military Medical University, Chongqing 400042, China)
关键词:
线性泛素化;  LUBAC复合体;  去泛素化酶;  肿瘤
Keywords:
linear ubiquitination;  LUBAC complex;  deubiquitin enzymes;  cancer
分类号:
R73
DOI:
10.3969/j.issn.1672-271X.2019.04.011
文献标志码:
A
摘要:
泛素化修饰在许多生理过程中起着重要作用，如细胞存活、细胞分化以及免疫反应等。线性泛素化修饰是近年来发现的一种特殊类型的翻译后修饰方式。该过程主要是由泛素连接酶复合体LUBAC催化和特异性去泛素化酶水解完成，目前的研究主要涉及免疫、炎症反应和血管生成等过程。随着研究的进展，发现线性泛素化修饰在肿瘤的发生过程中也具有重要的作用。文章将从LUBAC复合体、线性去泛素化酶、线性泛素化修饰的底物以及相关的小分子抑制剂等方面进行综述。
Abstract:
Ubiquitination plays an important role in many physiological processes, such as cell survival, cell differentiation, and immune response. Linear ubiquitination is a unique type of post-translational modification found in recent years. The process is mainly carried out by the ubiquitin ligase complex LUBAC catalysis and specific deubiquitination enzyme hydrolysis. The current research mainly involves in immunity, inflammation and angiogenesis. With the development of research, it has been found that linear ubiquitination also plays an important role in tumorigenesis. This article reviews the LUBAC complex, linear deubiquitinating enzymes, substrates of linear ubiquitination and related small molecule inhibitors.

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备注/Memo

备注/Memo:
收稿日期：2019-03-11
更新日期/Last Update: 2019-07-11