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[1]薛红,姚敏,岳明,等.303例丙型病毒性肝炎患者的生化特征分析[J].医学研究与战创伤救治(原医学研究生学报),2019,21(5):455-459.[doi:10.3969/j.issn.1672-271X.2019.05.002]
　XUE Hong,YAO Min,YUE Ming,et al.Analysis of biochemical characteristics in 303 HCV infected patients[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2019,21(5):455-459.[doi:10.3969/j.issn.1672-271X.2019.05.002]
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303例丙型病毒性肝炎患者的生化特征分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第21卷
期数:
2019年5期
页码:
455-459
栏目:
临床研究
出版日期:
2019-09-06

文章信息/Info

Title:
Analysis of biochemical characteristics in 303 HCV infected patients
文章编号:
1672-271X（2019）05-0455-05
作者:
薛红;  姚敏;  岳明;  黄鹏;  张云;  邵建国
作者单位：226001南通，南通大学医学院免疫学系（姚 敏）; 210029南京，南京医科大学第一附属医院感染病科（岳 明）; 211166南京，南京医科大学公共卫生学院传染病重点实验室（黄 鹏、张 云）; 226001南通，南通大学附属南通市第三人民医院肝病科（薛 红），消化科
Author(s):
XUE Hong1;  YAO Min2;  YUE Ming3;  HUANG Peng4;  ZHANG Yun4;  SHAO Jian-guo5
(1.Department of Hepatology，the Nantong Third Affiliated Hospital of Nantong University，Nantong 226001，Jiangsu，China; 2.Department of Immunology，Medical School of Nantong University，Nantong 226001，Jiangsu，China; 3.Department of Infectious Diseases，the First Affiliated Hospital of Nanjing Medical University，Nanjing 210029，Jiangsu，China; 4.Key Laboratory of Infectious Diseases，School of Public Health，Nanjing Medical University，Nanjing 211166，Jiangsu，China)
关键词:
丙型肝炎病毒;  生化指标;  病毒载量;  感染结局
Keywords:
hepatitis C virus;  biochemical markers;  viral load;  infection outcome
分类号:
R446.1;R512.62
DOI:
10.3969/j.issn.1672-271X.2019.05.002
文献标志码:
A
摘要:
目的 筛选肝功能相关的生化指标以及比较丙型肝炎病毒（HCV）感染后病毒不同复制状态患者的生理状态，旨在发现最适合反映HCV感染状况的生化指标。 方法 采用流行病学调查收集303例丙型病毒性肝炎患者的相关信息，其中HCV病毒清除者130例（清除组），HCV病毒复制者173例（复制组）。采集每位调查对象10 mL的清晨空腹静脉血，检测患者的血常规、肝肾功能、凝血功能和甲状腺功能。偏相关分析肝功能的相关生化指标以及与HCV病毒感染状态的关系。 结果 调整年龄、性别后，偏相关分析表明，淋巴细胞计数、单核细胞计数、凝血酶原时间和ALT、AST之间存在正相关关系（P<0.05）。单因素分析表明，HCV不同感染状态组的血常规、肝功能和凝血功能之间的差异具有显著性。纳入年龄、性别和以上在不同感染状态分布有差异的指标进行多因素逐步回归分析，结果表明HCV不同感染状态组的ALT和腺苷脱氨酶（ADA）水平之间存在显著性差异（P=0.008和0.032）。 结论 淋巴细胞计数、单核细胞计数、凝血酶原时间是与肝功能相关的其他生化指标，HCV清除组和HCV复制组的ALT、ADA水平的不同提示感染HCV不同结局者的生理状态。
Abstract:
Objective To screen biochemical markers related to liver function and compare the physiological status of patients with different HCV infection status. Besides，to identify biochemical indicators that are most suitable for assessing disease progression and patient prognosis. Methods Epidemiological investigations were conducted to collect relative information of 303 HCV patients，including 130 cases of negative HCV RNA(clearance group) and 173 cases of positive HCV RNA(reproduction group). We collected 10 mL of venous blood of each subject in the morning after a fasting，used appropriate instruments to detect blood routine，liver and kidney function，coagulation function，and thyroid function. Partial correlation analysis was used to find related biochemical indexes of liver function and their relationship with HCV infection status. Results Partial correlation analysis after adjusting for age and gender showed that there were positive correlations between lymphocyte count，monocytes，prothrombin time and ALT，AST（P<0.05）.There were significant differences among the blood routine，liver function and coagulation function of different HCV infection status by univariate analysis. Stepwise regression analysis of age，gender，and above differential biochemical indicators showed that there was a remarkable difference between ALT and ADA in different infection status groups（P=0.008，0.032）. Conclusion Lymphocyte count，monocytes，and prothrombin time are biochemical markers related to liver function. Different levels of ALT and ADA in the HCV clearance group and the HCV replication group could suggest the physiological status of patients with different outcomes of HCV infection.

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相似文献/References:

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　LIN Xiu-rong,CHEN Qiao-hui,LIN Hai..Study on rapid detecting and genotyping of HCV gene by TaqMan-MGB probes[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(5):20.

备注/Memo

备注/Memo:
收稿日期：2018-10-12
更新日期/Last Update: 2019-09-06