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[1]田茜,李宝新,郭淑芹,等.不同分期糖尿病视网膜病变患者血清长正五聚蛋白3表达变化及其相关因素分析[J].医学研究与战创伤救治(原医学研究生学报),2020,22(2):138-142.[doi:10.3969/j.issn.1672-271X.2020.02.006]
　TIAN Xi,LI Bao xin,GUO Shu qin,et al.Changes of serum pentraxin 3 levels in patients with different stages of diabetic retinopathy and influencing factors analysis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2020,22(2):138-142.[doi:10.3969/j.issn.1672-271X.2020.02.006]
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不同分期糖尿病视网膜病变患者血清长正五聚蛋白3表达变化及其相关因素分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第22卷
期数:
2020年2期
页码:
138-142
栏目:
临床研究
出版日期:
2020-03-11

文章信息/Info

Title:
Changes of serum pentraxin 3 levels in patients with different stages of diabetic retinopathy and influencing factors analysis
作者:
田茜; 李宝新; 郭淑芹; 张玛丽; 李杰; 李娜; 常文龙; 王翯; 张云良
作者单位：071000 保定，承德医学院附属保定市第一中心医院内分泌科（田茜、李宝新、郭淑芹、张玛丽、李杰、李娜、常文龙、王翯、张云良）
Author(s):
TIAN Xi;  LI Baoxin;  GUO Shuqin;  ZHANG Mali;  LI Jie;  LI Na;  CHANG Wenlong;  WANG He;  ZHANG Yunliang
(Department of Endocrinology, Baoding NO.1 Central Hospital Affiliated Chengde Medical College, Baoding 071000，Hebei,China)
关键词:
不同分期; 糖尿病; 视网膜病变; 正五聚蛋白3; 相关因素分析
Keywords:
different stages;  diabetes mellitus;  retinopathy;  pentraxin 3; influencing factors analysis
分类号:
R587.1
DOI:
10.3969/j.issn.1672-271X.2020.02.006
文献标志码:
A
摘要:
目的研究不同分期糖尿病视网膜病变患者血清长正五聚蛋白3（pentraxin 3,PTX3）水平变化及其相关因素分析。方法选取2016年10月至2018年10月在保定市第一中心医院内分泌科收治的2型糖尿病患者164例作为研究对象，依据WHO推荐的糖尿病视网膜病变的分期标准将其分为非视网膜病变组（NDR组）60例、非增殖期视网膜病变组（NPDR组）54例、增殖期视网膜病变组（PDR组）50例，选取同期体检的50例健康人群作为正常对照组，记录各组一般资料,测定血清生化指标[空腹静脉血糖（FBG）、糖化血红蛋白（HbA1c）、胰岛素（INS）等]，计算稳态模型评估胰岛素抵抗指数(HOMAIR)，应用ELISA法检测血清PTX3水平。应用Pearson相关分析血清PTX3与各指标的相关性，Logistic回归分析血清PTX3与糖尿病视网膜病变的相关关系。结果糖尿病各组血清PTX3水平[NDR组(21.39±2.48)ng/mL、NPDR组(27.01±11.27)ng/mL、PDR组(38.81±18.28)ng/mL]较正常对照组[(14.47±2.48)ng/mL]均升高(P＜0.05)。随着糖尿病视网膜病变病情程度的进展，PTX3水平逐渐升高，以PDR组最高(P＜0.05)。Pearson相关分析结果显示，血清PTX3水平与糖尿病病程、FBG、HbA1c、INS、HOMAIR等呈正相关（r分别为0.37、0.52、0.57、0.21、0.41, P＜0.01），进一步Logistic回归分析结果显示PTX3为DR发生的独立影响因素，并影响病情的发展。结论随着糖尿病视网膜病变病情的进展，血清PTX3水平逐渐升高，PTX3可能参与糖尿病视网膜病变的发生并影响病情严重程度。
Abstract:
ObjectiveTo investigate the change of serum pentraxin 3(PTX3) levels and related risk factors in patients with different stages of diabetic retinopathy.MethodsA total of 164 patients with type 2 diabetes mellitus(T2DM) from Department of Endocrinology, Baoding First Central Hospital from October 2016 to October 2018 were enrolled in this study.According to the WHO’s recommended diagnostic criteria for staging of diabetic retinopathy,the diabetes patients were divided into three group: nondiabetic retinopathy(NDR) group(n=60),nonproliferative diabetic retinopathy(NPDR) group(n=54) and proliferative diabetic retinopathy(PDR) group(n=50).Meanwhile, we recruited 50 healthy adults who received medical examination in this hospital during the same period as the control group(NC). The general data of the subjects were recorded and the biochemical indicators were detected.Serum PTX3 levels were measured by ELISA. Pearson correlation analysis and logistic regression analysiswere used to explore the relationship of serum PTX3 levels with other clinical indicators.ResultsCompared with the NC group, serum PTX3 levels were significantly elevated in the other groups（P＜0.05). Serum PTX3 levels in NC group, NDR group, NPDR group and PDR group were （14.47±2.48）ng/mL,(21.39±2.48)ng/mL,(27.01±11.27)ng/mL,(38.81±18.28)ng/mL. As the degree of diabetic retinopathy progresses,the serum levels of PTX3 gradually increased, and those in the PDR group were the highest(P＜0.05).Pearson correlation analysis showed that serum PTX3 levels were positively correlated with diabetes duration, FBG, HbA1c, INS, HOMAIR (r=0.37,0.52,0.57,0.21,0.41,respectively, P＜0.01). Logistic regression analysis showed that PTX3 was an independent influencing factor of DR and affected the development of the disease.ConclusionWith the progress of diabetic retinopathy, serum PTX3 levels were gradually increased.PTX3 may be involved in the development of diabetic retinopathy and affect the severity of the disease.

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备注/Memo

备注/Memo:
基金项目：河北省医学适用技术跟踪项目（GL201679）
更新日期/Last Update: 2020-03-11