|本期目录/Table of Contents|

[1]段姣,田蜜综述,李伟彦审校.神经炎症与围术期神经认知障碍的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2020,22(2):188-192.[doi:10.3969/j.issn.1672-271X.2020.02.016]
　DUAN Jiao,TIAN Mi reviewing,LI Wei yan checking.Review of neuroinflammtion and perioperative neurocognitive disorders[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2020,22(2):188-192.[doi:10.3969/j.issn.1672-271X.2020.02.016]
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神经炎症与围术期神经认知障碍的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第22卷
期数:
2020年2期
页码:
188-192
栏目:
综述
出版日期:
2020-03-11

文章信息/Info

Title:
Review of neuroinflammtion and perioperative neurocognitive disorders
作者:
段姣; 田蜜综述; 李伟彦审校
作者单位：210002 南京，南方医科大学南京临床医学院（东部战区总医院）麻醉科[段姣（医学硕士研究生）、田蜜、李伟彦]
Author(s):
DUAN Jiao;  TIAN Mi reviewing; LI Weiyan checking
（Department of Anesthesiology, Jinling Hospital,Nanjing School Clinical Medicine， Southern Medical University/General Hospital of Eastern Theater Command，PLA，Nanjing 210002，Jiangsu，China）
关键词:
神经炎症; 围术期神经认知障碍; 炎症因子; 术后认知障碍
Keywords:
neuroinflammation; perioperative neurocognitive disorders; inflammatory factors; postoperative cognitive disorders
分类号:
R749.1
DOI:
10.3969/j.issn.1672-271X.2020.02.016
文献标志码:
A
摘要:
神经炎症已成为神经系统并发症的一个重要标志，如围术期神经认知障碍(PND)。PND是最近被推荐用于术前和术后认知障碍的总称，其特点为记忆、注意力、信息处理和认知灵活性等认知功能下降。PND与更长的住院时间和更多治疗费用有关，PND患者的死亡率和残疾率与非PND患者相比更高，造成了巨大的社会负担。然而，到目前为止PND的发病机制仍不明确，越来越多的研究证据表明神经炎症是PND的关键因素。文章主要对神经炎症在PND中发挥作用的分子细胞机制以及围术期神经认知障碍疾病的治疗方法进行综述。
Abstract:
Neuroinflammation has become a hallmark of neurological complications, such as perioperative neurocognitive disorders(PND). PND is a recently recommended overarching term for cognitive impairment in preoperative and postoperative, which is characterized as a decline in cognitive functions including memory,attention,information processing and cognitive flexibility.PND is associated with longer hospitalization and more treatment costs,mortality and disability rates in patients with PND are higher than those in nonPND patients resulting in a huge communal burden. However, the pathogenesis of PND is still unclear . Increasing evidence suggests that neuroinflammation is a key factor in PND . In this paper, we summarize the molecular and cellular mechanisms of neuroinflammation in PND, discuss two kinds of diseases of PND, and list some therapeutic methods under study.

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备注/Memo

备注/Memo:
基金项目：南京军区医药卫生科研基金(MS109)
更新日期/Last Update: 2020-03-11