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[1]苏东玮,刘锋,毛发江,等.新型军用便携式抗菌负压引流系统对爆炸伤创面愈合的影响[J].医学研究与战创伤救治(原医学研究生学报),2020,22(4):337-341.[doi:10.3969/j.issn.1672-271X.2020.04.001]
　SU Dong-wei,LIU Feng,MAO Fa-jiang,et al.Study on the effect of a new military portable antibacterial negative pressure drainage system on the wound healing of explosive injury[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2020,22(4):337-341.[doi:10.3969/j.issn.1672-271X.2020.04.001]
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新型军用便携式抗菌负压引流系统对爆炸伤创面愈合的影响()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第22卷
期数:
2020年4期
页码:
337-341
栏目:
出版日期:
2020-07-20

文章信息/Info

Title:
Study on the effect of a new military portable antibacterial negative pressure drainage system on the wound healing of explosive injury
作者:
苏东玮; 刘锋; 毛发江; 方国恩
作者单位：200433 上海，解放军海军军医大学第一附属医院普外科（苏东玮、方国恩）；400038 重庆，解放军陆军军医大学教保处（刘锋）；200071 上海，上海中医药大学附属上海市中医医院科研处（毛发江）
Author(s):
SU Dong-wei1;  LIU Feng2;  MAO Fa-jiang3;  FANG Guo-en1
（1.Department of General Surgery, the First Affiliated Hospital of PLA Naval Medical University, Shanghai 200433, China;2. Department of Education and Social Security Office of PLA Army Medical University, Chongqing 400038, China;3. Department of Scientific Research Office, Affiliated Shanghai Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, China）
关键词:
便携; 抗菌; 负压引流; 爆炸伤; 创面愈合
Keywords:
portable;  antibacterial;  negative pressure drainage;  explosion wound;  healing
分类号:
R826.1
DOI:
10.3969/j.issn.1672-271X.2020.04.001
文献标志码:
A
摘要:
目的研究新型军用便携式抗菌负压引流系统对爆炸伤创面愈合的影响。方法选取15只健康小型白家猪，在双侧臀部制作30个爆炸伤创面，左右侧臀部随机分为对照组和实验组，每组15个创面。伤后2 d均不予治疗，以引发创面感染。伤后第3天起，对照组行常规负压引流，实验组使用新型军用便携式抗菌负压引流系统治疗。比较2组治疗前和治疗1、3、5、7 d创面细菌计数、创面深度、引流液炎性因子水平变化以及2组创面愈合时间。结果30个创面均建模成功，平均创面面积为（7.36±1.25）cm2。实验组治疗1、3、5、7 d时创面细菌计数均较治疗前下降且低于对照组同时期水平，对照组治疗3、5、7 d时创面细菌计数较治疗前下降，差异有统计学意义（P＜0.05）。实验组治疗后创面深度较治疗前下降，对照组治疗7 d时创面深度较治疗前下降；治疗7 d时，实验组创面平均深度低于对照组，差异有统计学意义（P＜0.05）。实验组治疗3、5、7 d时引流液TNF-α均较治疗1 d时升高，IL-1、IL-6均较治疗1 d时下降，差异有统计学意义（P＜0.05）。实验组创面愈合时间（24.69±1.82）d少于对照组（32.36±2.45）d，差异有统计学意义（P＜0.05）。 结论便携式抗菌负压引流系统能够有效减少创面细菌数量、降低创面深度、调节创面炎性因子水平，促进爆炸伤创面愈合。
Abstract:
ObjectiveTo study the effect of a new type of military portable antibacterial negative pressure drainage system on the healing of explosive wounds.MethodsFifteen healthy small white domestic pigs were selected, and 30 explosive wounds were made on both hips using electric detonators. The left and right hips were randomly divided into a research group and a control group, each with 15 wounds. No treatment was given 2 days after wound injury in both groups to induce wound infection. From the third day after the injury, the control group received conventional negative pressure drainage, and the research group was treated with a new military portable antibacterial negative pressure drainage system. Compare the changes of bacterial counts, wound depth, and drainagefluid inflammatory factor levels in the two groups before and 1 day, 3 days, 5 days, and 7 days of treatment, and compare the healing time of the two groups.ResultsAll 30 wounds were successfully modeled. The average wound area of model animals were (7.36±1.25) cm2. In the study group, the bacterial counts on the wounds at 1 d, 3 d, 5 d, and 7 d were lower than those before the treatment and were lower than those in the control group. The bacterial counts in the control group were 3 d, 5 d, and 7 d after treatment. The difference was statistically significant (P<0.05). The depth of the wound in the study group was lower than that before the treatment. The depth of the wound in the control group was higher than that before the treatment at 1 d, 3 d, and 5 d after treatment. The depth of the wound was lower at 7 d than that before the treatment. The average wound depth in the group was lower than that in the control group, and the difference was statistically significant (P<0.05). The TNF-α in the drainage fluid of the study group at 3 d, 5 d, and 7 d was higher than that at 1 d, and the levels of IL-1 and IL-6 were lower than those at 1 d. The difference was statistically significant (P<0.05); TNF-α and IL-1 in the drainage fluid showed no significant changes in the control group during 1 to 7 days of treatment. The wound healing time in the study group was (24.69±1.82) days, which were lower than that of control group (32.36±2.45) days, and the difference was statistically significant (P<0.05).ConclusionThe antibacterial portable negative pressure drainage system can effectively reduce the number of wound bacteria, reduce the depth of the wound, regulate the level of inflammatory factors in the drainage fluid, and promote the healing of explosive wounds.

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备注/Memo

备注/Memo:
基金项目：海军军医大学军事科研项目（2016JS23）
更新日期/Last Update: 2020-07-13