|本期目录/Table of Contents|

[1]牛文浩,周梦良,王强,等.节细胞胶质瘤患者手术前后癫痫发作的危险因素分析[J].医学研究与战创伤救治(原医学研究生学报),2020,22(4):356-361.[doi:10.3969/j.issn.1672-271X.2020.04.005]
 NIU Wen-hao,ZHOU Meng-liang,WANG Qiang,et al.Risk factors for pre- and postoperative seizures in patients undergoing ganglioglioma resection in a single-institution series[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2020,22(4):356-361.[doi:10.3969/j.issn.1672-271X.2020.04.005]
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节细胞胶质瘤患者手术前后癫痫发作的危险因素分析()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第22卷
期数:
2020年4期
页码:
356-361
栏目:
临床研究
出版日期:
2020-07-20

文章信息/Info

Title:
Risk factors for pre- and postoperative seizures in patients undergoing ganglioglioma resection in a single-institution series
作者:
牛文浩周梦良王强朱义豪费茂星汤婷王汉东潘灏
作者单位:210002南京,东南大学医学院第二临床学院(东部战区总医院)神经外科(牛文浩、周梦良、王强、朱义豪、费茂星、汤婷、王汉东、潘灏)
Author(s):
NIU Wen-haoZHOU Meng-liangWANG QiangZHU Yi-haoFEI Mao-xingTANG TingWANG Han-dongPAN Hao
(Department of Neurosurgery, the Second Clinical College of Southeast University, School of Medicine, General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China)
关键词:
节细胞胶质瘤癫痫危险因素回顾性分析
Keywords:
ganglioglioma seizure risk factors retrospective study
分类号:
R651.11;R742.1
DOI:
10.3969/j.issn.1672-271X.2020.04.005
文献标志码:
A
摘要:
目的探讨节细胞胶质瘤患者手术前后癫痫发作的危险因素。 方法回顾性分析1991年1月至2018年12月于东部战区总医院神经外科接受手术治疗的58例节细胞胶质瘤患者的临床资料,收集患者基本信息、临床特点、影像及病理资料等,通过电话随访和定期复查等方式了解患者出院后癫痫控制效果,以及治疗、复发及生存情况。对节细胞胶质瘤患者的资料进行单因素相关分析和多元logistic回归分析。 结果58例中,术前癫痫发作30例(51.7%)。49例进行临床随访,26例术前有癫痫发作,其中Engel Ⅰ级19例(73.1%),Engel Ⅱ级4例(15.4%),Engel Ⅲ级2例(7.7%),Engel Ⅳ级1例(3.8%)。多因素回归分析发现,存在头痛/头晕(OR:0.145,95%CI:0.029~0.719,P=0.018)、神经功能损伤(OR:0.025,95%CI:0.003~0.207,P=0.001)、颞叶肿瘤(OR:9.981,95%CI:1.829~54.453,P=0.008)是术前癫痫发作的显著预测因素;术前癫痫发作(OR:86.672,95%CI:3.356~2238.585,P=0.007)和手术切除程度(OR:0.034,95%CI:0.005~0.245,P=0.001)是术后癫痫发作的重要独立预测因素。结论存在头痛/头晕、神经功能损伤症状的患者术前癫痫发作率低,颞叶肿瘤位更易发作癫痫,术前存在癫痫发作的患者术后癫痫发作的危险性增加,肿瘤全切能够较好地控制癫痫发作症状。
Abstract:
ObjectiveTo investigate risk factors for pre-and postoperative seizures in patients undergoing resection of ganglioglioma in a single-institution.MethodsRetrospective chart review of 58 subjects undergoing resection of ganglioglioma was performed at the author’s institution (1991-2018). These basic information included the number of cases, patient’s gender, age of diagnosis, sites of tumor, etc.ResultsAmong 58 cases, 30 subjects (51.7%) had preoperative seizures. Among 49 patients followed, 26 cases had the history of preoperative seizure. Of these, Engel grade Ⅰ, Ⅱ, Ⅲ, and Ⅳ was reported on 19 cases (73.1%), 4 (15.4%), 2 (7.7%), and 1 (3.8%), respectively. Multivariate analysis identified accompanying symptoms of headache or dizzy (OR: 0.145,95%CI: 0.029-0.719, P=0.018), neurological deficit (OR: 0.025, 95%CI: 0.003-0.207, P=0.001) and temporal tumors (OR: 9.981,95%CI: 1.829-54.453, P=0.008) decreased odds of preoperative seizures. Preoperative seizures (OR: 86.672, 95%CI: 3.356-2238.585, P=0.007) was associated with postoperative seizures. Gross total removal (OR: 0.034, 95%CI: 0.005-0.245, P=0.001) decreased odds of postoperative seizures.ConclusionSymptoms of headache or dizzy, neurologicaldeficit and temporal tumors were important independent predictors of preoperative seizure. Gross total removal of ganglioglioma results in a better prognosis for postoperative seizures.

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备注/Memo

备注/Memo:
基金项目:国家自然科学基金(81672503)
更新日期/Last Update: 2020-07-13