|本期目录/Table of Contents|

[1]陈慧敏,王立群,黄利民,等.降钙素原变化率对创伤后脓毒症患者抗生素合理使用的指导价值[J].医学研究与战创伤救治(原医学研究生学报),2020,22(4):408-410.[doi:10.3969/j.issn.1672-271X.2020.04.016]
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降钙素原变化率对创伤后脓毒症患者抗生素合理使用的指导价值()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第22卷
期数:
2020年4期
页码:
408-410
栏目:
出版日期:
2020-07-20

文章信息/Info

Title:
-
作者:
陈慧敏; 王立群; 黄利民; 聂时南
作者单位：210002 南京，东部战区总医院(原南京军区南京总医院)急诊医学科(陈慧敏、黄利民、聂时南),军队伤病员管理科（王立群）
Author(s):
-
关键词:
降钙素原变化率; 脓毒症; 创伤; 抗生素合理使用
Keywords:
-
分类号:
R631.2
DOI:
10.3969/j.issn.1672-271X.2020.04.016
文献标志码:
B
摘要:
目的探讨降钙素原变化率对创伤后脓毒症患者抗生素合理使用的指导价值。方法回顾性分析2015年1月至2019年6月东部战区总医院收治的290例创伤后脓毒症患者的临床资料，按照不同抗生素治疗原则分为指导组和对照组各145例。对照组施行标准化抗生素治疗方案，指导组根据降钙素原变化率调整抗生素治疗方案。比较2组患者基本临床资料、抗生素使用时间及费用、重症监护病房（ICU）入住时间、不良反应发生率及死亡率。结果指导组治疗期间调整抗生素用药的平均时间明显短于对照组[（2.46±0.72）d vs 4.23±1.25）d，P<0.01]，抗生素调整频次明显高于对照组[（5.25±1.41）次 vs （3.31±1.50）次，P<0.01]。指导组的抗生素使用时间[（8.24±2.05）d]、抗生素费用[（8268.57±2405.43）元]、ICU入住时间[（12.48±3.52）d]均较对照组[（15.13±6.14）d、（13 654.35±3824.64）元、(23.07±5.70）d]明显减少（P<0.01）。指导组不良反应发生率明显低于对照组（12.41% vs 29.66%，P<0.01），死亡率比较差异无统计学意义（6.21% vs 8.97%，P>0.05）。结论根据降钙素原变化率调整创伤后脓毒症患者抗生素使用，可避免滥用抗生素、减轻患者不良反应及经济负担，且降钙素原检测方法简便，值得临床进一步推广。
Abstract:
-

参考文献/References:

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备注/Memo

备注/Memo:
基金项目：全军后勤科研面上项目(CNJ14L002，CLB18J030)
更新日期/Last Update: 2020-07-13