|本期目录/Table of Contents|

[1]张毅,彭玲玲,黄丽玲.广东某军队医院2019年多重耐药菌检出现状及耐药性分析[J].医学研究与战创伤救治(原医学研究生学报),2021,23(01):45-49.[doi:10.3969/j.issn.1672-271X.2021.01.001]
　ZHANG Yi,PENG Ling-ling,HUANG Li-ling.Analyze the distribution and drug susceptibility of multi-drug-resistant bacteria in patients admitted to a military hospital in Guangdong in 2019[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(01):45-49.[doi:10.3969/j.issn.1672-271X.2021.01.001]
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广东某军队医院2019年多重耐药菌检出现状及耐药性分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年01期
页码:
45-49
栏目:
出版日期:
2021-01-20

文章信息/Info

Title:
Analyze the distribution and drug susceptibility of multi-drug-resistant bacteria in patients admitted to a military hospital in Guangdong in 2019
作者:
张毅; 彭玲玲; 黄丽玲
作者单位：510010广州，南部战区总医院药剂科（张毅、黄丽玲）;510010广州，中山大学孙逸仙纪念医院药剂科(彭玲玲)
Author(s):
ZHANG Yi1;  PENG Ling-ling2;  HUANG Li-ling1
(1.Department of Pharmacy, General Hospital of the Southern Theater Command, PLA, Guangzhou 510010, Guangdong, China; 2.Department of Pharmacy, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510010, Guangdong, China)
关键词:
多药耐药菌; 病原菌; 临床分布; 耐药性
Keywords:
multidrug-resistant organisms;  pathogenic bacteria;  distribution;  drug resistance
分类号:
R969.3
DOI:
10.3969/j.issn.1672-271X.2021.01.001
文献标志码:
A
摘要:
目的了解医院多重耐药菌（MDROs）分布特点、耐药数据，为临床多重耐药菌防控及抗菌药物的合理应用提供依据。方法对2019年1月1日至12月31日南部战区总医院送检的住院患者的5273份临床培养标本，进行病原菌分离及鉴定，并对其在临床的分布以及耐药率进行统计分析。结果2019年共分离出病原菌4418例，多重耐药菌1505株，检出率为32.07%；以产超广谱β-内酰胺酶大肠埃希菌（ESBL+E.coli）为主，检出684株，占45.45%；多重耐药菌多集中在泌尿外科、呼吸内科、重症医学科；多重耐药菌最多来源于呼吸道标本（507株、占33.69%）。ESBL+E.coli及产超广谱β-内酰胺酶肺炎克雷伯菌（ESBL+Kpn）对亚胺培南、厄他培南、哌拉西林他唑巴坦、阿米卡星等的耐药率低（均＜5%）；耐甲氧西林金黄色葡萄球菌（MRSA）对万古霉素、利奈唑胺、链阳霉素耐药率均为0%；耐碳青霉烯类鲍曼不动杆菌（CRAB）仅对替加环素的耐药率较低，为23.80%；耐碳青霉烯类铜绿假单胞菌（CRPA）及耐碳青霉烯类肠杆菌科细菌（CRE）对阿米卡星耐药率均较低，分别为10.00%、23.70%。结论住院患者多药耐药菌感染分布较广，医院应继续加强多重耐药菌监测和防控，对有效减少重症感染发生率及指导临床合理使用抗菌药物具有重要意义。
Abstract:
ObjectiveTo analyze the distribution and drug susceptibility of multi-drug-resistant organisms (MDROs) in patients in 2019 and to guide clinical rational application of antibacterial drugs.MethodsThe pathogen isolation was separated from clinical specimens and collected from January 2019 to December 2019. Pathogens were isolated and identified through experiments, and their clinical distribution and drug resistance rates were statistically analyzed.ResultsA total of 4418 pathogens and 1505 MDROs were isolated, and the MDROs detection rate was 32.07%, among that ESBL+E.coli accounted for the greatest proportion with 45.45%. MDROs were most derived from respiratory specimens (507 isolates, 33.69%). ESBL+E.coli and ESBL+Kpn had lower resistance rates to imipenem, ertapenem, piperacillin-tazobactam and amikacin. The drug resistance rates of MRSA to vancomycin, linezolid, streptogramin were both 0%. CRAB had a low resistance rate of 23.80% to tigecycline. The resistance rates of CRPA and CRE to amikacin were 10.00% and 23.70%, respectively.ConclusionThe MDROs infections are widely distributed. The strengthen ofthe monitoring and prevention of MDROs is critical for guiding the rational clinical application of antibiotics and slowing down the MDROs formation.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2021-01-26