|本期目录/Table of Contents|

[1]李瑶,钟勇,王永园,等.运动习惯对新兵首次高强度训练后心肌损伤的影响[J].医学研究与战创伤救治(原医学研究生学报),2021,23(6):561-565.[doi:10.3969/j.issn.1672-271X.2021.06.001]
　LI Yao,ZHONG Yong,WANG Yong-yuan,et al.Effect of exercise habits on the myocardial injury of recruits after the first-time high-intensity training[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(6):561-565.[doi:10.3969/j.issn.1672-271X.2021.06.001]
点击复制

运动习惯对新兵首次高强度训练后心肌损伤的影响()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年6期
页码:
561-565
栏目:
出版日期:
2021-12-15

文章信息/Info

Title:
Effect of exercise habits on the myocardial injury of recruits after the first-time high-intensity training
作者:
李瑶; 钟勇; 王永园; 张洁; 吕磊
作者单位：210002南京，东部战区总医院（原南京军区南京总医院）心脏内科干部病区（李瑶、王永园、吕磊），健康管理中心（钟勇）；100101北京，战略支援部队特色医学中心心血管内科（张洁）
Author(s):
LI Yao; ZHONG Yong; WANG Yong-yuan; ZHANG Jie; L Lei
（1.Department of Geriatric Cardiology, 2.Health Management Centre, General Hospital of Eastern Theater Command, PLA, Nanjing 210002，Jiangsu, China; 3.Department of Cardiology, Characteristic Medical Center of Strategic Support Force, Beijing 100101, China）
关键词:
运动习惯; 运动性心肌损伤; 心肌损伤标志物; 儿茶酚胺
Keywords:
exercise habits;  exercise-induced myocardial injury;  myocardial injury markers;  catecholamine
分类号:
R541
DOI:
10.3969/j.issn.1672-271X.2021.06.001
文献标志码:
A
摘要:
目的观察不同运动习惯的新兵首次进行5 km长跑高强度训练前后心肌损伤标记物和儿茶酚胺水平的变化，探讨运动习惯对运动性心肌损伤的影响及可能机制。方法对某部队新兵进行体育活动等级量表（PARS-3）测评，评分≤19分者45名，为波动量组，≥43分者33名，为大运动量组，2组作为训练组均进行首次5 km长跑高强度训练，同时随机入组30名新兵保持静息状态作为对照组，对比静息/训练前及静息/训练后30 min肌钙蛋白I（TnI）、天门冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）、肌酸激酶（CK）、肌酸激酶同工酶（CK-MB）、缺血修饰蛋白（IMA）、肌红蛋白（MB）等心肌损伤标记物及肾上腺素(E)、去甲肾上腺素（NE）、多巴胺（DA）等儿茶酚胺（CA）水平的变化，比较对照组、波动量组与大运动量组运动前后心肌损伤标记物及CA水平变化的差异。结果对照组新兵静息前后AST、LDH、CK、CK-MB、MB、TnI、CA、E、NE、DA水平无显著变化，训练组新兵训练后30 min AST、LDH、CK、CK-MB及MB水平较训练前显著增高[（42.00±21.75 ）U/L vs （30.80±17.03）U/L，（295.57±106.58）U/L vs （268.56±185.95）U/L，（580.60±1298.57）U/L vs（519.86±1225.52）U/L，（24.63±12.62）U/L vs（20.03±11.25）U/L，（103.05±100.23）ng/mL vs（71.02±88.82）ng/mL，P＜0.05 ]，TnI水平较训练前也有所升高，但差异无统计学意义[（ 0.032±0.008）ng/mL vs（0.031±0.007）ng/mL，P＞0.05]；CA、E、NE训练后水平较训练前均明显升高[（834.41±250.40）pg/mL vs（291.09±89.80）pg/mL，（112.89±47.86）pg/mL vs（33.42±10.91）pg/mL，（697.48±235.95）pg/mL vs（233.72±82.24）pg/mL，P＜0.05]；大运动量组新兵训练前后TnI、CA、E、NE变化水平与波动量组相比明显降低[（0.001±0.001）ng/mL vs（0.003±0.002）ng/mL，（457.03±150.23）pg/mL vs（567.40±317.30）pg/mL，（384.46±138.41）pg/mL vs（483.59±295.53）pg/mL，（66.49±41.76）pg/mL vs（87.35±50.22）pg/mL，P＜0.05]。结论高强度训练可致新兵运动性心肌损伤，可能与CA水平激增有关，良好的运动习惯可以减轻心肌损伤程度，减少CA释放，对心肌具有保护作用。
Abstract:
ObjectiveTo observe the changes of myocardial injury markers and catecholamine of recruits with different exercise habits before and after 5 km running high-intensity training, and to explore the effect and possible mechanisms of exercise habits on exercise-induced myocardial injury.MethodsAll recruits completed the physical activity rating scale (PARS-3). 45 recruits who were rated as the fluctuating-exercise group and 33 as the high-exercise group were observed. All participators underwent 5 km running-training were rated as the training group. The other 30 recruits kept resting as the control group randomly. The level of troponin I (TnI), aspartate aminotransferase (AST), lactate dehydrogenase (LDH), creatine kinase (CK), creatine kinase isoenzyme (CK-MB), ischemia modified protein (IMA), myoglobin (MB), epinephrine (E), norepinephrine (NE), dopamine (DA), and catecholamine (CA) before and after 30 minutes of training were analyzed. Changes of myocardial injury markers and catecholamine before and after 30 minutes of training were compared between the fluctuating-exercise group and the high-exercise group.ResultsThere was no significant difference in the levels of AST, LDH, CK, CK-MB, MB, CA, E, NE and DA before and after resting. Compared to before training, the levels of AST, LDH, CK, CK-MB and MB were significantly increased after 30 minutes of training [(42.00±21.75) U/L vs (30.80±17.03) U/L, (295.57±106.58) U/L vs (268.56±185.95) U/L, (580.60±1298.57) U/L vs (519.86±1225.52) U/L, (24.63±12.62) U/L vs (20.03±11.25) U/L, (103.05±100.23) ng/mL vs (71.02±88.82) ng/mL, P＜0.05 ]. The level of TnI was also increased, but there was no significant difference [( 0.032±0.008) ng/mL vs (0.031±0.007) ng/mL, P＞0.05]. The levels of CA, E and NE were significantly higher than those before training [(834.41±250.40) pg/mL vs (291.09±89.80) pg/mL, (112.89±47.86) pg/mL vs (33.42±10.91) pg/mL, (697.48±235.95) pg/mL vs (233.72±82.24) pg/mL, P＜0.05]. Compared with the fluctuating-exercise group, the increases of TnI, CA, E and NE in the high-exercise group after training were significantly decreased [(0.001±0.001) ng/mL vs (0.003±0.002) ng/mL, (457.03±150.23) pg/mL vs (567.40±317.30) pg/mL, (384.46±138.41) pg/mL vs (483.59±295.53) pg/mL, (66.49±41.76) pg/mL vs (87.35±50.22) pg/mL, P＜0.05].ConclusionHigh intensity training can cause myocardial injury in recruits, which may be related to the sharp increase of CA. Good exercise habits can have a protective effect myocardium by reducing the degree of myocardial injury and decreasing the release of CA.

参考文献/References:

[1]平政，曹雪滨. 运动性心脏损伤的防治与机制研究进展[J]. 解放军医药杂志，2018，30（2）：110-113.
[2]刘梦露，刘华龙，洪葵. 儿茶酚胺与应激性心肌病发病机制的研究进展[J]. 中国心脏起搏与电生理杂志，2019，33（2）：160-162.
[3]赵毅，张国礼，徐凯扬. 体育锻炼对身体自尊的影响[J]. 体育大视野，2018，8（3）：246-250.
[4]Ping Z，Zhang LF，Cui YJ，et al．The Protective Effects of Salidroside from Exhaustive Exercise-Induced Heart Injury by Enhancing the PGC-1α-NRF1/NRF2 Pathway and Mitochondrial Respiratory Function in Rats［J］. Oxid Med Cell Longev，2015. doi: 10.1155/2015/876825.
[5]徐鹏，康亭，刘海燕，等. 力竭运动后不同时相大鼠心电图、心功能变化及 Nrf2 的作用[J]. 中国应用生理学杂志，2016，32（2）： 146-151.
[6]Vincent L，Maria T，Paul D，et al. Exercise-induced cardiac troponin I increase and incident mortality and cardiovascular events[J]. Circulation，2019，140（10）：804-814.
[7]刘杨，吴志峰. 运动性心肌微损伤的研究现状[J]. 东南国防医药，2014,16（4）：401-403.
[8]Watanabe M，Izumo M，Akashi YJ. Novel understanding of takotsubo syndrome[J]. Int Heart J，2018，59（2）：250.
[9]谢亮，刘挺松，宫剑滨. 应激性心肌病的研究进展[J]. 东南国防医药，2015，17（1）：70-72.
[10]刘军杰，梁斌，杨晓梅，等. 心理应急大鼠血浆NO水平及内皮细胞NO调控蛋白表达的变化[J]. 医学研究生学报，2014，27（11）：1124-1127.
[11]Land S，Niederer SA，Louch WE，et al. Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle[J]. Am J Physiol Heart Circ Physiol, 2014, 307(10): H1487-H1496.
[12]Chen W， Dilsizian V. Exploring the Pathophysiology of takotsubo cardiomyopathy[J]. Curr Cardiol Rep，2017，19(6)：53.
[13]王晓春，梁玉记，王燕，等．NF-κB-p65、ICAM-1 和细胞凋亡在力竭性运动诱发延迟性心肌损伤中的作用[J]. 心脏杂志，2013，10(2)：240-242.
[14]李晶晶，徐鹏，平政，等. 运动预适应对力竭大鼠心功能的影响[J]. 解放军医药杂志，2019，31（7）：9-14.
[15]孟丹，李鹏，黄雄，等．短期和长期运动预适应对力竭大鼠心肌损伤的保护作用[J]. 中国应用生理学杂志，2017，33(6): 531-534.
[16]马涛，高炳宏，李涛．8周有氧水上划艇训练对赛艇运动员某些儿茶酚胺和心率变异性指标的影响[J]. 中国应用生理学杂志，2019，35(3): 219-222.

相似文献/References:

[1]王永园,吕磊,李瑶,等.新兵首次长跑训练前后心电图以及氧化应激指标水平对比分析[J].医学研究与战创伤救治(原医学研究生学报),2021,23(03):240.[doi:10.3969/j.issn.1672-271X.2021.03.004]
　WANG Yong-yuan,L Lei,LI Yao,et al.Effect of first-time high-intensity exercise on ECG changes and oxidative stress[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(6):240.[doi:10.3969/j.issn.1672-271X.2021.03.004]

备注/Memo

备注/Memo:
基金项目：军委后勤保障部卫生局保健专项课题（18BJZ13）
更新日期/Last Update: 2021-12-15