|本期目录/Table of Contents|

[1]王娟,王春红,丁颖.轻中度睑板腺功能障碍患者的视觉质量分析[J].医学研究与战创伤救治(原医学研究生学报),2021,23(6):623-626.[doi:10.3969/j.issn.1672-271X.2021.06.014]
　WANG Juan,WANG Chun-hong,DING Ying.Evaluation of visual quality in patients with mild or moderate meibomian gland dysfunction[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(6):623-626.[doi:10.3969/j.issn.1672-271X.2021.06.014]
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轻中度睑板腺功能障碍患者的视觉质量分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年6期
页码:
623-626
栏目:
临床研究
出版日期:
2021-12-15

文章信息/Info

Title:
Evaluation of visual quality in patients with mild or moderate meibomian gland dysfunction
作者:
王娟; 王春红; 丁颖
作者单位：210002南京，东部战区总医院（原南京军区南京总医院） 眼科（王娟、王春红、丁颖）
Author(s):
WANG Juan;  WANG Chun-hong;  DING Ying
(Department of Ophthalmology,General Hospital of Eastern Theater Command，PLA,Nanjing 210002, Jiangsu ，China)
关键词:
睑板腺功能障碍;  视觉质量; 双通道技术
Keywords:
meibomian gland dysfunction;  optical quality;  scattering
分类号:
R775
DOI:
10.3969/j.issn.1672-271X.2021.06.014
文献标志码:
A
摘要:
目的用双通道视觉质量分析仪(OQASⅡ)，观察分析轻中度睑板腺功能障碍 (MGD)患者的视觉质量，为临床治 疗时机的选择提供参考依据。方法选择2018年4月至2019年1月于东部战区总医院眼科门诊就诊确诊为轻度MGD(30例 ，30眼)、中度MGD(30例，30眼)患者。同时随机选择30例无任何眼表疾病的健康人的30眼作为对照组。每位受试对 象填写眼表疾病指数量表(OSDI)，进行睑板腺相关检查，泪膜破裂时间测定，泪液分泌功能测定，利用OQAS-Ⅱ系统 检测自然状态下的调制传递函数截止频率(MTF cut off)、斯特列尔比(SR)、客观散射指数(OSI)，同时检测受试对 象20 s不眨眼过程中的视觉质量动态变化，获取OSI均值及标准差(SD-OSI)。比较各组间检查数据的差异。结果轻度 MGD组的SR为（0.24±0.06），MTF cut off为 (39.88±6.92) c/deg，OSI为(0.44±0.11), OSI均值为 (0.894±0.331)，SD-OSI为(0.113±0.041)。中度MGD组SR为(0.18±0.04)，MTF cut off为(32.27±8.53) c/deg， OSI为(0.71±0.23)，OSI均值为(1.574±0.554)，SD-OSI 为(0.246±0.157。轻度MGD组SR、MTF cut off、OSI与对 照组比较差异均无统计学意义(P>0.05)， OSI均值、SD-OSI显著高于对照组(P<0.01)。中度MGD组SR、MTF cut off 显著低于对照组(P<0.01)，OSI、OSI均值和SD-OSI显著高于对照组(P<0.01)。结论轻中度MGD患者的动态视觉质量下 降明显。OQAS可以有效地评估轻中度MGD患者的视觉质量。
Abstract:
ObjectiveTo evaluate the optical quality in patients with mild or moderate meibomian gland dysfunction (MGD) by using double-pass optical quality analysis system (OQASⅡ), and offer the reference data for clinical application．MethodsWe recruited 30 participants with mild MGD, 30 participants with moderate MGD, and 30 healthy subjects. Ocular surface disease index scores, meibomian gland correlation examination, tear film breakup time (BUT), Schirmer test (SIT) value, the modulation transfer function (MTF) cutoff frequency, the Strehl ratio (SR), and the objective scattering index (OSI) were quantitatively assessed using OQASⅡ. The mean OSI and OSI standard deviation (SD-OSI) were performed over 20 seconds without blinking to evaluate the dynamic alterations of optical quality. Differences between both groups were analyzed statistically.ResultsIn the mild MGD group, SR was (0.24±0.06), MTF cut off was (39.88±6.92) c/deg, OSI was (0.44±0.11), the mean OSI was (0.894±0.331) and SD-OSI was (0.113±0.041). In the moderate MGD group, SR was (0.18±0.04), MTF cut off was (32.27±8.53) c/deg, OSI was (0.71±0.23), the mean OSI was (1.574±0.554) and SD-OSI was (0.246±0.157). There was no significant difference in MTF cutoff, SR and OSI between the mild MGD group and the control group (P>0.05). The mean OSI and SD-OSI in mild MGD group were significantly higher than that in the control group (P<0.01). The SR and MTF cutoff were significantly lower and the OSI, the mean OSI and SD-OSI were significantly higher in the moderate MGD patients than controls (P<0.01).ConclusionThe dynamic alterations of optical quality in patients with mild-moderate MGD is lower than that of normal persons. The OQAS could be a useful tool to preferably evaluate visual function in patients with mild or moderate MGD.

参考文献/References:

[1]Tashbayev B, Yazdani M, Arita R, et al.Intense pulsed light treatment in meibomian gland dysfunction:A concise review[J]. Ocul Surf, 2020, 18(4):583-594.
[2]Cheng SN, Jiang FG, Chen H, et al.Intense Pulsed Light Therapy for Patients with Meibomian Gland Dysfunction and Ocular Demodex Infestation[J]. Curr Med Sci, 2019,39(5):800-809.
[3]胡晓丹, 吕会斌, 江晓丹, 等.睑板腺功能障碍与睑板脂质改变[J]. 中华眼科杂志， 2015,51(3):225-229.
[4]Borchman D, Ramasubramanian A, Foulks Gn.Human Meibum Cholesteryl and Wax Ester Variability With Age, Sex, and Meibomian Gland Dysfunction[J]. Invest Ophthalmol Vis Sci， 2019,60(6):2286-2293.
[5]Paranjpe V, Tan J, Nguyen J,et al.Clinical Signs of Meibomian Gland Dysfunction (MGD) Are Associated With Changes in Meibum Sphingolipid Composition[J]. Ocul Surf， 2019,17(2):318-326.
[6]薛春燕，王春红，黄振平.超声乳化人工晶体植入治疗葡萄膜炎并发白内障的临床效果[J]. 东南国防医药， 2018,20(3):229-231.
[7]Hwang JS, Lee YP, Bae SH, et al.Utility of the optical quality analysis system for decision-making in cataract surgery[J]. BMC Ophthalmol, 2018,18(1):231.
[8]Shine WE, Mcculley JP.Association of meibumoleic acid with meibomian seborrhea[J]. Cornea, 2000,19(1):72-74.
[9]饶甲环, 马煜盛, 龙洁旎，等.胆固醇酯转移蛋白抑制剂的研究进展[J]. 医学研究生学报, 2019，32(7)：776- 779.
[10]Patterson M, Vogel HJ, Prenner EJ.Biophysical characterization of monofilm model systems composed of selected tear film phospholipids [J]. Biochim Biophys Acta, 2016, 1858(2):403-414.
[11]Inaba T, Tanaka Y, Tamaki S,et al.Compensatory increases in tear volume and mucin levels associated with meibomian gland dysfunction caused by stearoyl-CoA desaturase-1 deficiency[J]. Sci Rep, 2018,8(1):3358.
[12]Arita R, Itoh K, Maeda S,et al.Proposed diagnostic criteria for obstructive meibomian gland dysfunction [J]. Ophthalmology, 2009,116(11):2058-2063.
[13]Fukuoka S， Arita R. Tear film lipid layer increase after diquafosol instillation in dry eye patients with meibomian gland dysfunction:a randomized clinical study[J]. Sci Rep, 2019， 9(1): 9091.
[14]Mudgil P, Borchman D, Gerlach D,et al.Sebum/Meibum Surface Film Interactions and Phase Transitional Differences[J]. Invest Ophthalmol Vis Sci, 2016,57(6):2401-2011.
[15]阮方，接英.睑板腺功能障碍的治疗进展[J]. 中华眼科杂志，2019,55(6):465-470.

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更新日期/Last Update: 2021-12-15