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[1]朱雷,薛春燕.Keap1-Nrf2信号通路在角膜急性紫外线损伤防治中的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2021,23(6):637-641.[doi:10.3969/j.issn.1672-271X.2021.06.017]
　ZHU Lei,XUE Chun-yan.Research progress of Keap1-Nrf2 signaling pathway in the prevention and treatment of acute UV damage in cornea[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(6):637-641.[doi:10.3969/j.issn.1672-271X.2021.06.017]
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Keap1-Nrf2信号通路在角膜急性紫外线损伤防治中的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第23卷
期数:
2021年6期
页码:
637-641
栏目:
综述
出版日期:
2021-12-15

文章信息/Info

Title:
Research progress of Keap1-Nrf2 signaling pathway in the prevention and treatment of acute UV damage in cornea
作者:
朱雷; 薛春燕
作者单位：210002南京,南京大学医学院附属金陵医院(东部战区总医院)眼科(朱雷、薛春燕)
Author(s):
ZHU Lei ;  XUE Chun-yan
(Department of Ophthalmology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, Jiangsu, China)
关键词:
角膜; 紫外线; 氧化应激; 活性氧自由基; 核因子E2相关因子2
Keywords:
cornea;  ultraviolet;  oxidative stress;  reactive oxygen species;  Nrf2
分类号:
R772.2
DOI:
10.3969/j.issn.1672-271X.2021.06.017
文献标志码:
A
摘要:
角膜位于眼球最外层，易遭受外界环境中紫外线刺激。户外运动者在高原冰雪环境中活动，紫外线暴露量大 ，如果防护不当，可发生雪盲症。目前报道的文献中，紫外线的生物危害效应主要由于其引起的氧化应激，但确切 的分子机制尚待进一步研究。Keap1-Nrf2-ARE信号通路在机体抗氧化应激损伤中发挥重要作用。文章主要就紫外线 引起氧化应激造成角膜损伤的分子机制以及Nrf2介导的抗氧化防御在角膜急性紫外线损伤防治中的研究进展进行综 述。
Abstract:
Locating at the outermost layer of the eye, the cornea, is vulnerable to UV irradiation. Soldiers are susceptible to snow blindness without protection during training at high altitudes. The biohazard effect of ultraviolet is mainly due to the oxidative stress induced by light in cells. The molecular mechanism of this effect remains to be further studied. Keap1-Nrf2 /ARE signaling pathway maintains cell activity and plays an important role in moderating the damage caused by oxidation. This paper reviews the mechanism of oxidative stress induced by UV and the potential role of Nrf2- mediated antioxidant defense in acute UV-induced corneal injury.

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备注/Memo

备注/Memo:
基金项目：军队医学科技青年培育计划拔尖项目（19QNP064）
更新日期/Last Update: 2021-12-15