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[1]肖文艳,胡娟娟,华天凤,等.早期中性粒细胞/淋巴细胞与血小板比值对发热伴血小板减少综合征患者病情及预后判断的价值分析[J].医学研究与战创伤救治(原医学研究生学报),2022,24(2):113-117.[doi:10.3969/j.issn.1672-271X.2022.02.001]
　XIAO Wen-yan,HU Juan-juan,HUA Tian-feng,et al.The prognostic value of neutrophils to lymphocytes and platelets ratio in patients with severe fever with thrombocytopenia syndrome[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(2):113-117.[doi:10.3969/j.issn.1672-271X.2022.02.001]
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早期中性粒细胞/淋巴细胞与血小板比值对发热伴血小板减少综合征患者病情及预后判断的价值分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年2期
页码:
113-117
栏目:
临床研究
出版日期:
2022-03-20

文章信息/Info

Title:
The prognostic value of neutrophils to lymphocytes and platelets ratio in patients with severe fever with thrombocytopenia syndrome
作者:
肖文艳; 胡娟娟; 华天凤; 郑瑶; 张洋; 李惠; 张金; 杨旻
作者单位：230601合肥，安徽医科大学第二附属医院心肺复苏与危重病实验室重症医学二科（肖文艳、胡娟娟、华天凤、郑瑶、张洋、李惠、张金、杨旻）
Author(s):
XIAO Wen-yan;  HU Juan-juan;  HUA Tian-feng;  ZHENG Yao; ZHANG Yang;  LI Hui;  ZHANG Jin;  YANG Min
(The 2nd Department of Intensive Care Unit,the Laboratory of Cardiopulmonary Resuscitation and Critical Care Medicine, the Second Affiliated Hospital of Anhui Medical University, Hefei 230601, Anhui, China)
关键词:
新型布尼亚病毒; 发热伴血小板减少综合征; 中性粒细胞/淋巴细胞与血小板比值; 预后
Keywords:
novel bunyavirus;  severe fever with thrombocytopenia syndrome;  neutrophils to lymphocytes and platelets ratio;  prognosis
分类号:
R512.8
DOI:
10.3969/j.issn.1672-271X.2022.02.001
文献标志码:
A
摘要:
目的研究早期中性粒细胞/淋巴细胞与血小板比值(N/LP)在发热伴血小板减少综合征(SFTS)成人患者中对疾病严重程度及预后的影响。方法回顾性分析2020年5月至 2021年6月于安徽医科大学第二附属医院住院治疗的SFTS成人患者38例的临床资料。比较轻症组（n=23）和重症组（n=15）患者的基线资料差异，分析相关的危险因素，采用ROC曲线计算N/LP最佳临界值。结果重症组患者较轻症组SFTS患者的年龄大、热程长、入住ICU风险高(P＜0.05)。在临床症状方面，重症组患者较症型组易出现肝损伤、急性胰腺炎（P＜0.05），并且特别容易出现中毒性脑病、心肌损伤以及肺部感染（P＜0.01）。N/LP预测患者病情严重程度的曲线下面积（AUC）较大，为0.745，最佳临界值为5.57，其敏感度为78.3％，特异度为73.3％。当N/LP>5.57时，可判别为重症SFTS患者，而当N/LP≤5.57时，可判别为轻症SFTS患者（P＜0.05）。而且当N/LP>5.57时，重症患者的存活率显著下降(P＜0.01)。 结论SFTS患者早期 N/LP的升高与病情严重程度及不良预后相关。
Abstract:
ObjectiveTo analyze the potential role and prognostic value of neutrophils to lymphocytes and platelets ratio (N/LP) at an early stage in patients with severe fever with thrombocytopenia syndrome (SFTS).MethodsA Total of 38 adult SFTS patients hospitalized in the Second Affiliated Hospital of Anhui Medical University from May 2020 to June 2021 was retrospectively analyzed. Baseline characteristics between the mild group (n=23) and the severe group (n=15) were compared to analyze the related risk factors, and the optimal threshold of N/LP was calculated by ROC curve.ResultsCompared with mild SFTS group, patients in severe group had older age, longer heat duration and higher risk of admission to ICU (P<0.05). In terms of clinical symptoms, SFTS patients in severe group were susceptible to liver injury, acute pancreatitis (P<0.05), more prone to toxic encephalopathy, myocardial injury and pulmonary infection (P<0.01) than those in mild group. The cut-off value of N/LP was 5.57 [sensitivity: 78.3%, specificity: 73.3%, and area under the curve (AUC): 0.745]. When N/LP>5.57, severe SFTS could be identified, while those could be identified in mild group. When N/LP>5.57, the survival rate of severe patients decreased significantly (P<0.01).ConclusionThe elevation of N/LP in early SFTS patients is related to the severity of disease and poor prognosis.

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相似文献/References:

备注/Memo

备注/Memo:
基金项目：国家自然科学基金（82072134）；安徽医科大学校科研基金（2019xkj032）
更新日期/Last Update: 2022-04-18