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[1]张峰磊,项兰兰,陈怡婷,等.孕前男性血清脂溶性维生素水平与精液质量相关性研究[J].医学研究与战创伤救治(原医学研究生学报),2022,24(2):138-141.[doi:10.3969/j.issn.1672-271X.2022.02.006]
　ZHANG Feng-lei,XIANG Lan-lan,CHEN Yi-ting,et al.Study on the correlation between the expression of serum lipid-soluble vitamin and semen quality in pre-pregnancy males[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(2):138-141.[doi:10.3969/j.issn.1672-271X.2022.02.006]
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孕前男性血清脂溶性维生素水平与精液质量相关性研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年2期
页码:
138-141
栏目:
临床研究
出版日期:
2022-03-20

文章信息/Info

Title:
Study on the correlation between the expression of serum lipid-soluble vitamin and semen quality in pre-pregnancy males
作者:
张峰磊; 项兰兰; 陈怡婷; 李海博; 潘连军; 潘锋
作者单位：210004南京，南京市妇幼保健院(南京医科大学附属妇产医院)泌尿男科（张峰磊、李海博、潘连军、潘锋），医学检验科（项兰兰、陈怡婷）
Author(s):
ZHANG Feng-lei;  XIANG Lan-lan;  CHEN Yi-ting;  LI Hai-bo;  PAN Lian-jun;  PAN Feng
(1.Department of Andrology,2.Clinical Laboratory, Nanjing Maternal and Child Health Care Hospital, Women’s Hospital of Nanjing Medical University, Nanjing 210004, Jiangsu, China)
关键词:
精液浓度; 精子活力; 精子形态; 维生素A; 维生素D; 维生素E; 维生素K
Keywords:
semen concentration;  sperm motility;  sperm morphology;  vitamin A;  vitamin D;  vitamin E;  vitamin K
分类号:
R698.2
DOI:
10.3969/j.issn.1672-271X.2022.02.006
文献标志码:
A
摘要:
目的探讨血清脂溶性维生素A、D、E及K水平与男性精液质量的相关性，指导男性孕前保健。方法回顾性分析2021年1月-6月在南京市妇幼保健院孕前保健门诊就诊的备孕前检查男性1028例，收集个人病史资料，统计检测的血清维生素A、D、E及K水平以及精液质量参数，并分析相关性。采用单因素分析、多因素Logistic回归分析血清脂溶性维生素与男性精液质量的关系。结果1028例研究对象中，精液异常者占60.5%（622/1028）。孕前男性普遍缺乏维生素D（99.03%，1018/1028），其中严重缺乏者占16.34%（168/1028），而维生素A、E、K正常分别占87.16%、82.49%、82.20%。血清维生素D水平与精子浓度存在相关性（r=0.065，P=0.037），补充维生素D后精子形态正常率平均值由原来的3.40%提高到4.34%（P<0.05）。其余维生素A、E、K水平与精液质量参数均无明显相关性（P>0.05）。多因素Logistic回归分析显示，维生素A、D、E、K为男性精液质量影响因素，但非独立影响因素。结论血清脂溶性维生素A、E及K与孕前男性精液质量无明显关联性，孕前男性血清维生素D水平普遍缺乏，与精子浓度存在相关性。适当补充维生素D可能对改善精子形态有益。
Abstract:
ObjectiveTo explore the correlation between the expression of serumlipid-soluble vitamin A, D, E and K values and semen quality, and to protect male fertility.MethodsWe retrospectively analyzed the clinical data of men who were examined in the pre-pregnancy health clinic from January 2021 to June 2021, collected their personal history information, and detected the expression of serum vitamin A, vitamin D, vitamin E, vitamin K and sperm quality, and analyzed the correlations. The relationship between the expression of serum lipid-soluble vitamin and the quality of male semen were analyzed by univariate analysis and multivariate logistic regression.ResultsA total of 1028 men was included in this study. 622 cases(622/1028, 60.5%) had abnormal semen quality. The pre-pregnancy males were generally deficient in vitamin D level (99.03%) (1018/1028). 168 cases (168/1028, 16.34%) were severely deficient, but the normal levels of vitamin A, E and K accounted for 87.16%, 82.49% and 82.20%, respectively. The serum vitamin D level had a correlation with sperm concentration (r=0.065, P<0.05). The mean value of sperm morphology was raised from 3.40% to 4.34% after rising of vitamin D level, manifesting its benefit to the sperm morphology improvement (P<0.05). There were no significant correlations between vitamin A, E, K levels and semen quality parameters (P>0.05). Multivariate logistic regression analysis showed that vitamins A, D, E, and K were influencing factors of male semen quality, but not the independent influencing factors.ConclusionSerum lipid-soluble vitamins A, E and K are not significantly related to male semen quality. It is common to see the lack of vitamin D in pre-pregnancy males. The vitamin D level is correlated to sperm concentration, and appropriate supplementation of it may improve sperm morphology.

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备注/Memo

备注/Memo:
基金项目：南京市卫生青年人才培养工程（QRX17071）
更新日期/Last Update: 2022-04-18