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[1]祁娜,白田妹,徐天朝.外周血单个核细胞TMEVPG1、NRON的表达与精神分裂症患者症状和认知功能的关系[J].医学研究与战创伤救治(原医学研究生学报),2022,24(2):152-156.[doi:10.3969/j.issn.1672-271X.2022.02.009]
　QI Na,BAI Tian-mei,XU Tian-chao.The relationship between the expression of TMEVPG1 and NRON in peripheral blood mononuclear cells and the symptoms and cognitive function of schizophrenia[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(2):152-156.[doi:10.3969/j.issn.1672-271X.2022.02.009]
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外周血单个核细胞TMEVPG1、NRON的表达与精神分裂症患者症状和认知功能的关系()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年2期
页码:
152-156
栏目:
临床研究
出版日期:
2022-03-20

文章信息/Info

Title:
The relationship between the expression of TMEVPG1 and NRON in peripheral blood mononuclear cells and the symptoms and cognitive function of schizophrenia
作者:
祁娜; 白田妹; 徐天朝
作者单位：110016沈阳，北部战区总医院精神心理科（祁娜、徐天朝），妇产科（白田妹）
Author(s):
QI Na; BAI Tian-mei; XU Tian-chao
（1.Department of Psychology, 2.Department of Obstetrics and Gynecology, General Hospital of Northen Theater Command，Shenyang 110016，Liaoning，China）
关键词:
精神分裂症; 外周血; 长链非编码RNA; 认知功能
Keywords:
schizophrenia;  peripheral blood;  long-chain non coding RNA;  cognitive function
分类号:
R749.3
DOI:
10.3969/j.issn.1672-271X.2022.02.009
文献标志码:
A
摘要:
目的探讨外周血单个核细胞长链非编码RNA TMEVPG1、NRON的表达水平与精神分裂症患者症状和认知功能的关系。方法用荧光定量PCR法检测68例首发未服药精神分裂症患者（精神分裂症组）和50例健康人（对照组）外周血单个核细胞TMEVPG1、NRON的表达水平。采用阳性与阴性症状量表（PANSS）评价症状严重程度；MATRICS 公认认知成套测验（MCCB）评价认知功能。结果精神分裂症组TMEVPG1、NRON的相对表达量分别为（4.80±1.12）和（3.14±1.24），对照组分别为（2.06±0.89）和（1.67±0.73），组间比较差异均有统计学意义（P＜0.01）。TMEVPG1、NRON诊断精神分裂症的受试者工作特征曲线下面积（AUC）分别为0.801和0.719，灵敏度分别为80.56%和72.95%，特异度分别为73.33%和81.10%，两者联合检测可将AUC提高至0.854。与对照组比较，精神分裂症组信息处理加工速度、注意警觉性、工作记忆、言语学习、视觉学习、推理问题解决和社会认知均较差（P＜0.01）。TMEVPG1和NRON水平均与PANSS量表阴性症状评分和总分呈正相关（r分别为0.480和0.370，P＜0.05）。TMEVPG1与精神分裂症患者信息处理加工速度和工作记忆呈负相关（ r分别为-0.321和-0.402，P＜0.05），NRON水平与注意警觉性呈负相关（r=-0.341，P＜0.05）。结论外周血单个核细胞TMEVPG1、NRON的表达与精神分裂症患者的阴性症状及认知功能有关。
Abstract:
ObjectiveTo investigatethe relationship between the expression of TMEVPG1 and NRON in peripheral blood mononuclear cells and the symptoms and cognitive function of schizophrenia.MethodsThe expression of TMEVPG1 and NRON in peripheral blood mononuclear cells of 68 patients (schizophrenia group) and 50 healthy people (control group) were detected by fluorescent quantitative PCR. PANSS and MCCB were used to evaluate the severity of symptoms and MATRICS consensus cognitive battery (MCCB) was used to evaluate the cognitive function.ResultsThe relative expression of TMEVPG1 and NRON were (4.80±1.12) and (3.14±1.24) in schizophrenia group, and (2.06±0.89) and (1.67±0.73) in control group, respectively. There was significant difference between the two groups (P<0.01). The area under the receiver operating characteristic curve (AUC) of TMEVPG1 and NRON in the diagnosis of schizophrenia were 0.801 and 0.719, respectively. The sensitivity was 80.56% and 72.95%, and the specificity was 73.33% and 81.10%, respectively. The AUC of the combined detection of TMEVPG1 and NRON was increased to 0.854. Compared with the control group, the speed of information processing, attention alertness, working memory, speech learning, visual learning, reasoning problem-solving and social cognition of schizophrenia group were worse (P<0.05). TMEVPG1 and NRON were positively correlated with PANSS negative symptom score and total score (r=0.480 and 0.370, respectively, P＜0.05). TMEVPG1 was negatively correlated with information processing speed and working memory in schizophrenics (r=-0.321 and -0.402, respectively, P＜0.05). And NRON was negatively correlated with attention alertness (r=-0.341，P＜0.05).ConclusionThe expression of TMEVPG1 and NRON in peripheral blood mononuclear cells is related to the negative symptoms and cognitive function of patients with schizophrenia.

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更新日期/Last Update: 2022-04-18