[1]白文栋,许琴,彭红艳,等.高原人员肠屏障损伤评估及其与维生素D、IGF-1和IL-6的相关性[J].医学研究与战创伤救治(原医学研究生学报),2022,24(3):328-330.[doi:10.3969/j.issn.1672-271X.2022.03.024]
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高原人员肠屏障损伤评估及其与维生素D、IGF-1和IL-6的相关性(
)
)《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]
- 卷:
- 第24卷
- 期数:
- 2022年3期
- 页码:
- 328-330
- 栏目:
- 出版日期:
- 2022-06-30
文章信息/Info
- Title:
- -
- Keywords:
- -
- 分类号:
- R823
- 文献标志码:
- A
- 摘要:
- 目的评估高原驻训人员肠屏障损伤，分析其与维生素D、胰岛素样生长因子1（IGF-1）和白细胞介素6（IL-6）的相关性，为高原病防治提供理论依据。方法选取高原地区驻训、平原地区驻营和驻训人员，分析其肠屏障损伤及肠道疾病的影响。检测高原驻训人员不同时间点D-二胺氧化酶（DAO）、D-乳酸（DLA）、内毒素（END）肠屏障损伤指标以及25（OH）D3、IGF-1和IL-6水平，分析高原驻训人员肠屏障损伤变化规律及与25（OH）D3、IGF-1、IL-6的相关性。结果高原驻训组人员DAO、DLA、END水平高于平原驻营、驻训组（P＜0.05）。肠易激综合征、炎症性肠病高原驻训组人员的肠屏障损伤指标水平高于无肠道疾病人员（P＜0.05）。高原驻训人员DAO、DLA、END和IL-6水平随驻训时间延长呈先升高后降低趋势，25（OH）D3、IGF-1水平呈降低趋势（P＜0.05）。且高原驻训人员DAO、DLA、END水平与25（OH）D3、IGF-1水平呈负相关，与IL-6水平呈正相关（P＜0.05）。结论高原驻训人员易发生肠屏障损伤，肠道疾病、驻训时间、维生素D、IGF-1和IL-6水平与肠屏障损伤相关，在高原病防治中应予以重视。
- Abstract:
- -
参考文献/References:
[1]Wang Y, Huo L. Role of TLR4/NF-κB pathway in the damage of acute hypobaric hypoxia to small intestinal mucosa in rats[J]. Gen Physiol Biophys,2021,40(1):79-88.
[2]Hassanshahi M, Anderson PH, Sylvester CL,et al. Current evidence for vitamin D in intestinal function and disease[J]. Exp Biol Med (Maywood),2019,244(12):1040-1052.
[3]Zhou W, Rowitz BM, Dailey MJ. Insulin/IGF-1 enhances intestinal epithelial crypt proliferation through PI3K/Akt, and not ERK signaling in obese humans[J]. Exp Biol Med (Maywood), 2018,243(11):911-916.
[4]Guo Y, Wang B, Wang T, et al. Biological characteristics of IL-6 and related intestinal diseases[J]. Int J Biol Sci, 2021,17(1):204-219.
[5]Cao YY, Wang ZH, Xu QC,et al. Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling[J]. Korean J Physiol Pharmacol,2021,25(4):375-383.
[6]Ghosh S, Whitley CS, Haribabu B,et al. Regulation of Intestinal Barrier Function by Microbial Metabolites[J]. Cell Mol Gastroenterol Hepatol, 2021,11(5):1463-1482.
[7]Assimakopoulos SF, Mastronikolis S, DE Lastic AL, et al. Intestinal Barrier Biomarker ZO1 and Endotoxin Are Increased in Blood of Patients With COVID-19-associated Pneumonia[J]. In Vivo, 2021,35(4):2483-2488.
[8]Hausmann J, Kubesch A, Amiri M,et al. Vitamin D Deficiency is Associated with Increased Disease Activity in Patients with Inflammatory Bowel Disease[J]. J Clin Med, 2019,8(9):1319-1326.
[9]Bohin N, McGowan KP, Keeley TM,et al. Insulin-like Growth Factor-1 and mTORC1 Signaling Promote the Intestinal Regenerative Response After Irradiation Injury[J]. Cell Mol Gastroenterol Hepatol, 2020,10(4):797-810.
[10]印中鹏,宋令雄,王苏梦,等. 血浆抗凝血酶Ⅲ和血清IL-6与降钙素原对判断克罗恩病活动性的临床价值[J]. 东南国防医药,2018,20(1):22-25.
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备注/Memo
- 备注/Memo:
- 基金项目：军队医学科技青年培育项目（19QNP001）
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