|本期目录/Table of Contents|

[1]王根旺,吕镗烽.基于SEER数据库中第一原发肺癌患者的远处转移特征及预后分析[J].医学研究与战创伤救治(原医学研究生学报),2022,24(4):350-355.[doi:10.3969/j.issn.1672-271X.2022.04.004]
　WANG Gen-wang,LV Tang-feng.Analysis of distant metastasis characteristics and prognosis of patients with the first primary lung cancer based on SEER database[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(4):350-355.[doi:10.3969/j.issn.1672-271X.2022.04.004]
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基于SEER数据库中第一原发肺癌患者的远处转移特征及预后分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年4期
页码:
350-355
栏目:
临床研究
出版日期:
2022-08-30

文章信息/Info

Title:
Analysis of distant metastasis characteristics and prognosis of patients with the first primary lung cancer based on SEER database
作者:
王根旺; 吕镗烽
作者单位：210002南京，南京大学医学院附属金陵医院(东部战区总医院)呼吸内科（王根旺、吕镗烽）
Author(s):
WANG Gen-wang; LV Tang-feng
(Department of Respiratory Medicine，Affiliated Jinling Hospital，Medical School of Nanjing University/General Hospital of Eastern Theater Command，PLA, Nanjing 210002，Jiangsu,China)
关键词:
肺癌; 病理类型; 转移模式; 预后因素; SEER数据库
Keywords:
lung cancer;  pathological type;  metastasis pattern;  prognostic factors;  SEER Database
分类号:
R734.2
DOI:
10.3969/j.issn.1672-271X.2022.04.004
文献标志码:
A
摘要:
目的通过对病例数据集的回顾性研究，探讨不同病理类型的肺癌转移模式以及其预后差异。方法借助美国监测、流行病学及终点事件（SEER）数据库，纳入2013-2016年第一原发肺癌的患者数据共65 361例，根据鳞癌、腺癌和小细胞癌等不同病理类型将患者分为3个亚组，分析每个亚组的远处器官转移模式并且采用COX回归方程确定影响肺癌预后的因素，利用K-M曲线计算转移和非转移患者的生存率和中位生存期。结果共有26451例（40.5%）发生了远处器官转移，其中腺癌最容易出现骨转移，较少出现肝转移；鳞癌最易出现骨转移，较少出现脑转移；而小细胞癌最易出现肝转移，较少出现肺转移。骨转移（HR 1.5；95%CI 1.4~1.5；P＜0.001)和脑转移（HR 1.5；95%CI 1.4~1.5；P＜0.001)的预后最差，肝转移也具有较高的死亡风险（HR 1.4；95%CI 1.3~1.4；P＜0.001)，肺转移相对来说预后表现较好（HR 1.1；95%CI 1.1~1.2；P＜0.001)。远处转移将患者的中位生存期从21.7个月缩短至6.9个月。结论不同病理类型的肺癌转移模式不同，且不同转移部位对肺癌的预后影响也存在差异。
Abstract:
ObjectiveTo investigate the metastasis pattern and prognosis of different pathological types of lung cancer through a retrospective study of a large number of public data.MethodsA total of 65 361 patients with primary lung cancer from 2013 to 2016 were included in the Surveillance, Epidemiology, and End Results (SEER) Database, according to the pathological types of squamous cell carcinoma, adenocarcinoma and small cell carcinoma, the patients were divided into three subgroups. the distant organ metastasis patterns of each subgroup were analyzed. The prognostic factors of lung cancer were determined by COX regression equation. K-M curve was used to calculate the survival rate and median survival time of metastatic and non-metastatic patients.ResultsA total of 26 451 (40.5%) patients had distant organ metastasis, in which adenocarcinoma had high frequency of bone metastasis and low frequency of liver metastasis. Squamous cell carcinoma had high frequency of bone metastasis and low frequency of brain metastasis, while small cell carcinoma had high frequency of liver metastasis and low frequency of lung metastasis. Bone metastasis (HR 1.5; 95%CI 1.4-1.5; P<0.001) and brain metastasis (HR 1.5; 95%CI 1.4-1.5; P<0.001) had the worst prognosis. Liver metastasis also had a higher risk of death (HR 1.4; 95%CI 1.3-1.4; P<0.001). Lung metastasis had a better prognosis (HR 1.1; 95%CI 1.1-1.2; P<0.001). In addition, distant metastasis reduced the median survival time from 21.7 months to 6.9 months.ConclusionDifferent pathological types of lung cancer have different metastatic patterns, and different metastatic sites have different impact on the prognosis of lung cancer.

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备注/Memo

备注/Memo:
基金项目：国家自然科学基金（82172728）
更新日期/Last Update: 2022-09-06