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[1]梁紫君,安红伟.ICAM-1、VEGF及ox-LDL与缺血性脑血管病患者颅内外动脉重度狭窄或闭塞的相关性[J].医学研究与战创伤救治(原医学研究生学报),2022,24(5):454-459.[doi:10.3969/j.issn.1672-271X.2022.05.002]
　LIANG Zi-jun,AN Hong-wei.Relationship between ICAM-1, VEGF, ox-LDL and severe stenosis or occlusion of intracranial and extracranial arteries in patients with ischemic cerebrovascular disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(5):454-459.[doi:10.3969/j.issn.1672-271X.2022.05.002]
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ICAM-1、VEGF及ox-LDL与缺血性脑血管病患者颅内外动脉重度狭窄或闭塞的相关性()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年5期
页码:
454-459
栏目:
临床研究
出版日期:
2022-11-02

文章信息/Info

Title:
Relationship between ICAM-1, VEGF, ox-LDL and severe stenosis or occlusion of intracranial and extracranial arteries in patients with ischemic cerebrovascular disease
作者:
梁紫君; 安红伟
作者单位：530000南宁，广西中医药大学研究生院（梁紫君）；545001柳州，广西中医药大学第三附属医院神经内科（安红伟）
Author(s):
LIANG Zi-jun1;  AN Hong-wei2
(1.Graduate School, Guangxi University of Chinese Medicine, Nanning 530000, Guangxi, China;2. Department of Neurology, the Third Affiliated Hospital of Guangxi University of Chinese Medicine, Liuzhou 545001, Guangxi, China)
关键词:
细胞间黏附分子-1; 血管内皮生长因子; 氧化型低密度脂蛋白; 缺血性脑血管病; 脑血管狭窄
Keywords:
intercellularadhesion molecule-1;  vascular endothelial growth factor;  oxidized low density lipoprotein;  ischemic cerebrovascular disease;  cerebral vascular stenosis
分类号:
R743.3
DOI:
10.3969/j.issn.1672-271X.2022.05.002
文献标志码:
A
摘要:
目的探讨血清细胞间黏附分子-1（ICAM-1）、血管内皮生长因子（VEGF）及氧化型低密度脂蛋白（ox-LDL）水平与缺血性脑血管病（ICVD）患者颅内外动脉重度狭窄或闭塞的相关性。方法选择2021年6月至2021年12月于广西中医药大学第三附属医院神经内科接受诊疗并且完成全脑血管造影检查的132例ICVD患者，根据脑血管造影检查结果评估患者的颅内外动脉狭窄程度，将患者分为狭窄组（60例）和对照组（72例）。收集患者的临床资料，测定各组患者血清ICAM-1、VEGF和ox-LDL水平并进行比较分析。结果狭窄组患者较对照组患者ICAM-1 [(4.29±3.41) vs (2.46±1.95) ng/mL]、VEGF[(497.73±358.95) vs (274.41±215.08) pg/mL]和ox-LDL[(17.72±13.29) vs (8.57±7.01) μg/mL]水平均显著升高（P＜0.01）。Spearman相关分析显示，狭窄组患者血清ICAM-1、ox-LDL水平与神经功能缺损严重程度呈正相关（r=0.336、0.284，P<0.05），ICAM-1与VEGF、ox-LD水平（r=0.897、0.945，P<0.05）及VEGF与ox-LDL水平呈正相关（r=0.882，P<0.05）。Logistic回归分析结果显示，高水平ICAM-1、VEGF和ox-LDL增加ICVD患者发生颅内外动脉重度狭窄或闭塞的风险（P<0.05）。ROC曲线分析显示，ICAM-1、VEGF、ox-LDL及三者联合预测ICVD患者颅内外动脉重度狭窄或闭塞的曲线下面积（AUC）分别为0.669、0.684、0.756和0.810，三者联合检测的预测价值最大（P<0.05）。结论ICAM-1、VEGF、ox-LDL与ICVD患者颅内外动脉重度狭窄或闭塞密切相关，可作为评估ICVD患者颅内外动脉重度狭窄或闭塞的预测指标。
Abstract:
ObjectiveTo investigate the correlation between the levels of serum intercellular adhesion molecule-1 (ICAM-1), vascular endothelial growth factor (VEGF), oxidized low density lipoprotein (ox-LDL) and severe stenosis or occlusion of intracranial and extracranial arteries in patients with ischemic cerebrovascular disease (ICVD).Methods132 patients with ICVD who underwent diagnosis and treatment at the Department of Neurology of the Third Affiliated Hospital of Guangxi University of Chinese medicine from June 2021 to December 2021 and completed whole cerebral angiography were selected. The degree of intracranial and extracranial artery stenosis was evaluated according to the results of cerebral angiography. Patients were divided into stenosis group (60 cases) and control group (72 cases). The clinical data of patients were gathered, and the levels of serum ICAM-1, VEGF and ox LDL in each group were measured and compared.ResultsThe levels of ICAM-1 [(4.29 ± 3.41) vs (2.46 ± 1.95) ng/mL], VEGF [(497.73 ± 358.95) vs (274.41 ± 215.08) pg/mL] and ox-LDL [(17.72 ± 13.29) vs (8.57 ± 7.01) μg/mL] in stenosis group were significantly higher than those in control group (P<0.01). Spearman correlation analysis showed that ICAM-1, ox-LDL were positively correlated with the severity of neurological deficit (r=0. 336, 0.284, P<0.05), ICAM-1 was positively correlated with VEGF, ox-LD (r=0. 897, 0.945, P<0.05), and VEGF was positively correlated with ox-LDL (r=0. 882, P<0.05). Logistic regression analysis showed that high levels of ICAM-1, VEGF and ox-LDL increased the risk of severe stenosis or occlusion of intracranial and extracranial arteries in ICVD patients (P<0.05). ROC curve analysis showed that the area under curve (AUC) of ICAM-1, VEGF, ox-LDL and their combination in predicting severe stenosis or occlusion of intracranial and extracranial arteries in ICVD patients was 0.669, 0.684, 0.756 and 0.810 respectively (P<0.05), and the combined detection of ICAM-1, VEGF, ox-LDL had the greatest predictive value.ConclusionICAM-1, VEGF and ox-LDL are closely related to severe stenosis or occlusion of intracranial and extracranial arteries in ICVD patients, and can be used as predictors to evaluate severe stenosis or occlusion of intracranial and extracranial arteries in ICVD patients.

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备注/Memo

备注/Memo:
基金项目：广西壮族自治区卫生健康委员会自筹经费科研课题（Z20210522）；柳州市科技计划项目（2019BJ10611）
更新日期/Last Update: 2022-11-16