|本期目录/Table of Contents|

[1]高虹宇,王少华,黎介寿.AMD1在肿瘤发生发展中的作用与干预研究进展[J].医学研究与战创伤救治(原医学研究生学报),2022,24(5):504-508.[doi:10.3969/j.issn.1672-271X.2022.05.012]
　GAO Hong-yu,WANG Shao-hua,LI Jie-shou.Research progress on the role and intervention of AMD1 in tumorigenesis and development[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(5):504-508.[doi:10.3969/j.issn.1672-271X.2022.05.012]
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AMD1在肿瘤发生发展中的作用与干预研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年5期
页码:
504-508
栏目:
综述
出版日期:
2022-11-02

文章信息/Info

Title:
Research progress on the role and intervention of AMD1 in tumorigenesis and development
作者:
高虹宇;  王少华; 黎介寿
作者单位：210002南京，南京大学医学院附属金陵医院（东部战区总医院）全军普通外科研究所（高虹宇、王少华、黎介寿)
Author(s):
GAO Hong-yu ;  WANG Shao-hua;  LI Jie-shou
(Research Institute of General surgery, Jinling Hospital, Medical School of Nanjing University/ General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China)
关键词:
S-腺苷蛋氨酸脱羧酶1; 肿瘤; 治疗
Keywords:
S-adenosylmethionine decarboxylase 1;  cancer;  treatment
分类号:
R73-3
DOI:
10.3969/j.issn.1672-271X.2022.05.012
文献标志码:
A
摘要:
多胺广泛存在于真核生物中, 其在细胞内水平维持在特定的生理范围内对维持正常的细胞功能非常重要，是必不可少的多聚阳离子。然而在肿瘤细胞中，多胺代谢异常失调大多是由于其代谢过程中的酶异常表达所致，因而靶向多胺生物合成的关键酶有望为临床肿瘤预防和治疗提供新靶点。S-腺苷蛋氨酸脱羧酶1（AMD1）是目前研究最多的多胺生物合成限速酶，通过使用特异性AMD1抑制剂及多胺类似物可调节体内多胺代谢,使其水平趋于正常。目前AMD1如何影响肿瘤发生发展的机制尚不清楚。文章主要就AMD1在肿瘤中的最新研究进展及AMD1抑制剂、多胺类似物在临床试验中的应用进行综述。
Abstract:
Polyamines widely exist in eukaryotes and are essential polycations substances. Polyamines intracellular maintain in a specific physiological range, which is essential to maintain normal function of cells. However, the abnormal metabolism of polyamines in tumor cells is mainly due to the abnormal expression of enzymes involved in its metabolism. Therefore, the key enzymes targeting polyamine metabolism are expected to provide new targets for the prevention and treatment of tumor. S-adenosylmethionine decarboxylase (AMD1), a rate-limiting enzyme of polyamine biosynthesis, is widely studied at present. It has been reported that by using specific AMD1 inhibitors and polyamine analogs to normalize the level of polyamine in vivo. However, the mechanism of the effect of AMD1 on tumorigenesis and development is still unclear. This review systematically summarizes the latest research progress of AMD1 in tumors and the application of AMD1 inhibitors and polyamine analogs in clinical trials.

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备注/Memo

备注/Memo:
基金项目：国家临床重点专科军队建设项目普通外科专项(2014ZDZK002)；江苏省临床医学中心（创新平台）项目(YXZXA2016006)
更新日期/Last Update: 2022-11-16