|本期目录/Table of Contents|

[1]孟小舟,张利东.Nrf2及其通路在脓毒症相关性脑病中的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2022,24(6):636-641.[doi:10.3969/j.issn.1672-271X.2022.06.015]
 MENG Xiao-zhou,ZHANG Li-dong.Research progress of Nrf2 and the related pathways in sepsis-associated encephalopathy[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(6):636-641.[doi:10.3969/j.issn.1672-271X.2022.06.015]
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Nrf2及其通路在脓毒症相关性脑病中的研究进展()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年6期
页码:
636-641
栏目:
综述
出版日期:
2023-01-18

文章信息/Info

Title:
Research progress of Nrf2 and the related pathways in sepsis-associated encephalopathy
作者:
孟小舟张利东
作者单位:210002南京,南京医科大学金陵临床医学院(东部战区总医院)麻醉科(孟小舟、张利东)
Author(s):
MENG Xiao-zhou ZHANG Li-dong
(Department of Anesthesiology, Jinling Hospital, Jinling School Clinical Medicine, Nanjing Medical University/General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China)
关键词:
核转录因子-E2相关因子2脓毒症相关性脑病认知功能Nrf2激活剂
Keywords:
nuclear factor erythroid 2-related factor 2 sepsis-associated encephalopathy cognitive function Nrf2 activator
分类号:
R742
DOI:
10.3969/j.issn.1672-271X.2022.06.015
文献标志码:
A
摘要:
脓毒症相关性脑病(SAE)发病机制复杂,死亡率高,传统的临床干预手段简单且有限,存活患者可能会发生长期认知功能障碍。核转录因子-E2相关因子2(Nrf2)是抗氧化和抗炎机制的中心调节因子,研究表明Nrf2可调节多种信号通路改善SAE预后和认知功能。因此Nrf2可能是SAE潜在的治疗靶点,Nrf2激活剂可能是SAE有前景的新型治疗策略。文章主要就Nrf2及其通路在SAE中的调节机制及Nrf2激活剂的研究进展进行综述。
Abstract:
Sepsis-associated encephalopathy (SAE) has complex pathogenesis and high mortality. Traditional clinical interventions are simple and limited, and surviving patients may develop long-term cognitive dysfunction. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a central regulator of antioxidant and anti-inflammatory mechanisms, and studies have shown that Nrf2 can regulate multiple signaling pathways to improve prognosis and cognitive function of SAE. Therefore, Nrf2 may be a potential therapeutic target for SAE. Nrf2 activator may be a promising novel therapeutic strategy for SAE. This review focuses on the regulatory mechanism of Nrf2 and the related pathways in SAE and the research progress of Nrf2 activator.

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备注/Memo

备注/Memo:
基金项目:军委后勤保障部卫生局军事医学创新工程专项基金(20WQ025)
更新日期/Last Update: 2023-01-18