|本期目录/Table of Contents|

[1]孔凯文,孟岩,邓小明.Nrf2/HO-1信号通路在急性肺损伤中的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2022,24(6):646-651.[doi:10.3969/j.issn.1672-271X.2022.06.017]
　KONG Kai-wen,MENG Yan,DENG Xiao-ming.Research progress of Nrf2/HO-1 signaling pathway in acute lung injury[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(6):646-651.[doi:10.3969/j.issn.1672-271X.2022.06.017]
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Nrf2/HO-1信号通路在急性肺损伤中的研究进展()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第24卷
期数:
2022年6期
页码:
646-651
栏目:
综述
出版日期:
2023-01-18

文章信息/Info

Title:
Research progress of Nrf2/HO-1 signaling pathway in acute lung injury
作者:
孔凯文; 孟岩; 邓小明
作者单位：200433上海，海军军医大学(第二军医大学)第一附属医院麻醉科（孔凯文、孟岩、邓小明）
Author(s):
KONG Kai-wen;  MENG Yan ;  DENG Xiao-ming
(Department of Anesthesiology, The First Affiliated Hospital of Naval Medical University/Second Military Medical University, Shanghai 200433, China)
关键词:
核因子E2相关因子2; 血红素加氧酶-1; 急性肺损伤; 急性呼吸窘迫综合征
Keywords:
nuclear factor E2-related factor 2; heme oxygenase-1; acute lung injury; acute respiratory distress syndrome
分类号:
R563
DOI:
10.3969/j.issn.1672-271X.2022.06.017
文献标志码:
A
摘要:
核因子E2相关因子2（Nrf2）是细胞内一种重要的转录因子，被激活后可促进其下游血红素加氧酶-1（HO-1）的表达。HO-1是血红素降解过程的限速酶，能够催化血红素降解为胆绿素、Fe2+和一氧化碳。由于HO-1及其催化产物具有显著的抗氧化和抗炎作用，近些年受到越来越多的关注。最近研究发现，Nrf2/HO-1信号通路在急性肺损伤/急性呼吸窘迫综合征（ALI/ARDS）中能够减轻炎症反应和氧化应激损伤，抑制细胞焦亡和铁死亡，进而减轻肺损伤。文章就Nrf2/HO-1信号通路在ALI/ARDS的最新研究成果进行综述。
Abstract:
Nuclear factor E2-related factor 2 (Nrf2) is a key transcription factor in cells, which can promote the expression of its downstream heme oxygenase-1 (HO-1) when activated. HO-1 is the rate-limiting enzyme in the degradation process of heme, which can catalyze the degradation of heme into biliverdin, Fe2+ and carbon monoxide. HO-1 and its catalytic products have received more and more attention in recent years due to their significant antioxidant and anti-inflammatory effects. Recent studies have found that Nrf2/HO-1 signaling pathway in ALI/ARDS can reduce the inflammatory response and oxidative stress injury, inhibit cell pyroptosis and ferroptosis, and then reduce lung injury. This article describes the latest research results of Nrf2/HO-1 signaling pathway in ALI/ARDS, in order to provide new therapeutic ideas.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2023-01-18