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[1]姚远,吴静,郑新莉,等.糖尿病足骨髓炎抗生素治疗时程及预后影响因素[J].医学研究与战创伤救治(原医学研究生学报),2025,38(01):63-68.[doi:10.16571/j.cnki.2097-2768.2025.01.010]
　YAO Yuan,WU Jing,ZHENG Xinli,et al.Study on the duration of antibiotic therapy and prognostic factors for osteomyelitis of diabetes foot[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2025,38(01):63-68.[doi:10.16571/j.cnki.2097-2768.2025.01.010]
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糖尿病足骨髓炎抗生素治疗时程及预后影响因素()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
38卷
期数:
2025年01期
页码:
63-68
栏目:
论著·临床研究
出版日期:
2025-01-20

文章信息/Info

Title:
Study on the duration of antibiotic therapy and prognostic factors for osteomyelitis of diabetes foot
文章编号:
2097-2768（2025）01-0063-04
作者:
姚远; 吴静; 郑新莉; 张姣; 郑伟
作者单位：239473 滁州，明光市人民医院内分泌科（姚远、吴静）；310013 杭州，解放军联勤保障部队第九〇三医院干部病房（郑新莉、郑伟）；210002 南京，东部战区总医院超声诊断科（张姣）
Author(s):
YAO Yuan; WU Jing; ZHENG Xinli; ZHANG Jiao; ZHENG Wei
（1.Department of Endocrinology，Mingguang People’s Hospital，Chuzhou 239473，Anhui，China;2.Cadre Ward，the903th Hospital of the Joint Logistics Support Force，PLA，Hangzhou 310013，Zhejiang，China;3.Department of Ultra?sound，General Hospital of Eastern Theater Command，PLA，Nanjing 210002，Jiangsu，China）
关键词:
糖尿病足骨髓炎; 抗生素; 风险因素
Keywords:
osteomyelitis of diabetic foot; antibiotics; riskfactor
分类号:
R587.1
DOI:
10.16571/j.cnki.2097-2768.2025.01.010
文献标志码:
A
摘要:
目的 探讨糖尿病足骨髓炎治疗过程中抗生素的使用时间对预后的影响。方法收集2022年6月至2024年5月明光市人民医院内分泌科因糖尿病足感染就诊的患者。将确诊糖尿病足的患者随机分成2组：短程组（抗生素治疗20 d，n=78）、长程组（抗生素治疗35 d，n=79）。比较两组中发生骨髓炎患者的临床结局，并通过Logistic回归分析影响骨髓炎愈合的风险因素。结果短程组36例患者发生糖尿病足骨髓炎，其中，24例骨髓炎完全缓解，22例糖尿病创面愈合；长程组40例发生糖尿病足骨髓炎，其中，26例骨髓炎完全缓解，24例糖尿病创面愈合。Logistic回归分析结果显示，DFI创面评分>16、红蓝光照射、下肢动脉介入或手术治疗及部分切除感染/坏死骨组织是影响糖尿病足骨髓炎临床预后的因素（P<0.05）。结论糖尿病足骨髓炎的治疗过程可适当控制抗生素的使用时间，有助于降低细菌耐药；患者的初始糖尿病创面评分与预后相关，治疗过程中，应积极开展红蓝光照射治疗、微创治疗扩张血管，改善血供，促进愈合，严格控制开展部分切除感染/坏死骨组织的手术。
Abstract:
Objective To compare the effects of the duration of antibiotic therapy on the prognosis of osteomyelitis of diabeticfoot. Methods We prospectively recruited the patients with diabetic foot infections from June 2022 to May 2024 in the Endocrinolo?gy Department of Mingguang People?s Hospital. These patients were randomly divided into two groups: one receiving short-term antibi?otic therapy（20 days，n=78）and the other receiveing long-term antibiotic treatment（35 days，n=79）. The clinical outcomes of thesepatients with osteomyelitis were compared. The risk factors affecting the osteomyelitis remission were analyzed by Logistic regression.Results In the short-term antibiotic treatment group，36 patients developed osteomyelitis of diabetes foot，with 24 patients achievingcomplete remission and 22 patients experiencing diabetic wound healing. In the long-term antibiotic group，40 patients developed osteo?myelitis of diabetic foot with 26 patients achieving complete remission of osteomyelitis and 24 patients experiencing diabetic woundhealing. Logistic regression analysis showed that diabetic foot infection（DFI）wound score>16，red and blue light therapy，lower limbartery intervention or surgical treatment，and partial amputation of infected and necrotic bones were significant factors affecting osteo?myelitis remission in diabetic foot（P<0.05）. Conclusion We should properly control the use time of antibiotics during the treat?ment of osteomyelitis of diabetic foot，which is helpful to reducebacterial resistance. The initial DFI wound score is a prognostic in?dicator，and Interventions such as Red and blue light therapy，mini?mally invasive treatments to improve blood and oxygen supply，andcautious partial amputation of infected and necrotic bones are rec?ommended to enhance outcomes.

参考文献/References:

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备注/Memo:
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更新日期/Last Update: 2025-01-20