[1]柏晓勇,刘隽,杨新怡,等.Wnt/β-catenin通路在Graves眼病患者中的表达及与临床疾病活动分数的关系[J].医学研究与战创伤救治(原医学研究生学报),2026,39(01):54-58.[doi:10.16571/j.cnki.2097-2768.2026.01.008]
 BO Xiaoyong,LIU Jun,YANG Xinyi,et al.Expression of the Wnt/βcatenin pathway and Graves′ ophthalmopathy and its clinical disease activity score[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2026,39(01):54-58.[doi:10.16571/j.cnki.2097-2768.2026.01.008]
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Wnt/β-catenin通路在Graves眼病患者中的表达及与临床疾病活动分数的关系()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第39卷
期数:
2026年01期
页码:
54-58
栏目:
临床研究
出版日期:
2026-01-20

文章信息/Info

Title:
Expression of the Wnt/βcatenin pathway and Graves′ ophthalmopathy and its clinical disease activity score
作者:
柏晓勇1刘隽1杨新怡1卢斌1叶小珍2邵加庆1
1.东部战区总医院内分泌科,江苏南京 2100022.南京大学医学院附属泰康仙林鼓楼医院内分泌科,江苏南京 210023
Author(s):
BO Xiaoyong1 LIU Jun1 YANG Xinyi1 LU Bin1 YE Xiaozhen2 SHAO Jiaqing1
(1.Department of Endocrinology, General Hospital of Eastern Theater Command, PLA, Nanjing 210002, Jiangsu, China; 2.Department of Endocrinology, Affiliated Taikang Xianlin Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210023, Jiangsu, China)
关键词:
Graves眼病Wnt/βcatenin信号通路临床疾病活动分数Dickkopf相关蛋白1过氧化物酶体增殖物激活受体γ透明质酸
Keywords:
Graves′ ophthalmopathyWnt/βcatenin clinical activity scoredickkopfrelated protein 1peroxisome proliferatoractivated receptorγhyaluronic acid
分类号:
R771.3
DOI:
10.16571/j.cnki.2097-2768.2026.01.008
文献标志码:
A
摘要:
目的探讨Wnt/βcatenin信号通路与Graves眼病的发病机制关系。方法选取2018年12月至2021年12月东部战区总医院内分泌科门诊确诊的98例初发Graves病患者。根据有无并发Graves眼病分为Graves眼病组(n=68)和对照组(n=30)。CAS≥3分为活动性Graves眼病,CAS<3分为稳定性Graves眼病。分析Wnt/βcatenin信号通路各因子表达异常与Graves眼病发病的关系。结果Graves眼病组血清Wnt10b、βcatenin水平低于对照组,而血清DKK1、PPARγ及HA水平高于对照组(P<0.05)。活动性Graves眼病患者血清Wnt10b、βcatenin水平低于稳定性Graves眼病患者,而血清DKK1、PPARγ及HA水平高于稳定性Graves眼病患者(P<0.05)。Spearman相关性分析显示,Graves眼病患者的血清Wnt10b、βcatenin水平与CAS分数呈负相关(r=-0.587、-0.764, P<0.05),而DKK1、PPARγ和HA水平与CAS分数呈正相关(r=0.722、0.784、0.832, P<0.05) 。多变量logistic回归分析显示,血清TRAb、Wnt10b、βcatenin、DKK1、PPARγ和HA水平与Graves眼病患者的CAS分数相关(P<0.05)。结论Wnt/βcatenin信号通路表达异常与Graves眼病的发病密切相关,且影响Graves眼病的疾病活动性,可作为Graves眼病治疗的新靶点。
Abstract:
ObjectiveThis study aimed to investigate the relations between Wnt/βcatenin pathway and the pathogenesis of Graves′ ophthalmopathy (GO).MethodsA total of 98 patients with newly diagnosed Graves′ ophthalmopathy admitted to the department of endocrinology at Jinling Hospital from December 2018 to December 2021 were selected. Based on the presence or absence of concurrent Graves′ ophthalmopathy, patients were divided into a Graves′ ophthalmopathy group (GO Group, n=68) and a control group (n=30). A CAS ≥3 was defined as active Graves′ ophthalmopathy, and a CAS <3 was defined as stable Graves′ ophthalmopathy. The relationship between abnormal expression of various factors in the Wnt/βcatenin signaling pathway and the pathogenesis of Graves′ ophthalmopathy was analyzed.ResultsThe serum levels of Wnt10b and βcatenin of the GO group were lower than those of the control group, while the levels of DKK1, HA and PPARγ were higher (P<0.05). Serum Wnt10b and βcatenin levels were lower in patients with active Graves′ ophthalmopathy than in patients with stable Graves′ ophthalmopathy, while serum DKK1, PPARγ, and HA levels were higher (P<0.05). Spearman correlation analysis showed that the serum level of Wnt10b and β catenin was negatively correlated with clinical disease activity score (CAS) (r=-0.587, -0.764, P<0.05), while DKK1 and PPAR γ and HA levels were positively correlated with CAS (r=0.722, 0.784, 0.832, P<0.05). Multivariate logistic regression analysis showed serum TRAb, Wnt10b, β Catenin, DKK1, PPARγ, and HA level were associated with the CAS of the GO patients.ConclusionWnt/βcatenin signaling pathway is closely related to the pathogenesis of GO, and affects the activity of Graves′ ophthalmopathy, thus it could serve as a novel therapeutic target for Graves′ ophthalmopathy.

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备注/Memo

备注/Memo:
基金项目:江苏省自然科学基金(BK20180295); 江苏省“六大高峰”高层次人才项目(WSW108)
更新日期/Last Update: 2026-01-20