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[1]杨洪光,李 峰,游淑红,等.乌司他丁联合连续性血液滤过治疗 多器官功能障碍综合征53例临床观察[J].医学研究与战创伤救治(原医学研究生学报),2008,10(03):189.
　YANG Hong-guang,LI Feng,YOU Shu-hong,et al.Clinical observation of 53 cases with multiple organ dysfunction syndrome treated with ulinastatin combines with continuous veno-venous hemofiltration[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(03):189.
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乌司他丁联合连续性血液滤过治疗 多器官功能障碍综合征53例临床观察()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第10卷
期数:
2008年03期
页码:
189
栏目:
出版日期:
2008-05-20

文章信息/Info

Title:
Clinical observation of 53 cases with multiple organ dysfunction syndrome treated with ulinastatin combines with continuous veno-venous hemofiltration
文章编号:
1672-271X(2008)03-0189-03
作者:
杨洪光; 李 峰; 游淑红; 徐芳林; 邹 廷页; 罗 云
九江市第一人民医院ICU，江西九江 332000
Author(s):
YANG Hong-guang; LI Feng; YOU Shu-hong; XU Fang-lin; ZOU Ting; LUO Yun
Department of ICU，the First People Hospital of Jiujiang，Jiujiang 332000,Jiangxi，China
关键词:
乌司他丁; 连续性血液滤过; 肿瘤坏死因子-α; 血栓素B2 ; 6-酮-前列腺素F1A; 多器官功能障碍综合征
Keywords:
Ulinastatin;  Continuous veno-venous hemofiltration;  TNF-α;  TXB2;  6-keto-PGF1a;  Multiple organ dysfunction syndrome
分类号:
R459.7
DOI:
-
文献标志码:
A
摘要:
目的 观察乌司他丁(UT)和连续性血液滤过(CVVH)治疗多器官功能障碍综合征(MODS)临床疗效。方法 103例MODS患者随机分为两组:对照组50例采用常规及CVVH治疗；治疗组53例在对照组的基础上加用乌司他丁。观察两组患者治疗前后APACHEⅡ评分，观察肿瘤坏死因子-α(TNF-α)、血栓素B2(TXB2)、6-酮-前列腺素F1A(6-keto-PGF1a)、肾功能的变化以及ICU住院天数、CVVH应用时间和患者死亡风险率。结果 两组患者治疗后APACHEⅡ评分均明显下降；血清TNF-α 、TXB2均较治疗前显著下降(P＜0.05)，血清6-keto-PGF1a均显著上升(P＜0.05)，但治疗组上述指标均优于对照组(P＜0.05)。两组患者死亡率无显著差异，但治疗组患者ICU住院天数及CVVH应用时间均优于对照组(P＜0.01)。结论 UT联合CVVH治疗MODS可取得更好疗效。
Abstract:
Objective To observe the clinical curative effect of treatment for multiple organ dysfunction syndrome with ulinastatin combines with continous veno-venous hemofiltration. Methods 103 cases of patients with multiple organ dysfunction syndrome were divided into two groups at random: 50 cases were control group treated with routine treatment and CVVH and 53 cases treated with intravenous injection of ulinastatin in addition to the same treatment as control group. The clinical situation of patients before and after treatment, hospital days in ICU, time for treatment with CVVH, dead risk for group, score of APACHEⅡ, serum concentration of TNF-α, TXB2 and F1A(6-keto-PGF1a), and change of renal function were observed. Results Score of APACHEⅡ, serum concentration of TNF-α and TXB2 were significantly decreased (P＜0.01) and F1A(6-keto-PGF1a) significantly increased(P＜0.01) after treatment for both groups, however, these parameters in treatment group were more significant than that in control group(P＜0.05). There was no significance for clinical situation and mortality rate between two groups. The clinical curative effect of hospital days in ICU, time for treatment with CVVH, and dead risk for group is better in treatment group than in control group(P＜0.05).Conclusion The clinical curative effect of treatment for MODS with UT combines with CVVH is satisfied.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-11-22