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[1]陈继龙,何帮顺,潘玉琴,等.子宫内膜异位症与雌激素受体α基因 多态性之间的相关性[J].医学研究与战创伤救治(原医学研究生学报),2008,10(04):267.
　CHEN Ji-long,HE Bang-shun,PAN Yu-qin,et al.Association of gene polymorphisms of estrogen receptor alpha with endometriosis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(04):267.
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子宫内膜异位症与雌激素受体α基因 多态性之间的相关性()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第10卷
期数:
2008年04期
页码:
267
栏目:
出版日期:
2008-07-20

文章信息/Info

Title:
Association of gene polymorphisms of estrogen receptor alpha with endometriosis
文章编号:
1672-271X(2008)04-0267-04
作者:
陈继龙1; 何帮顺2; 潘玉琴2; 王书奎2
1.东南大学临床医学院，江苏南京210009；2.南京医科大学附属南京第一医院中心实验室，江苏南京210006
Author(s):
CHEN Ji-long1;  HE Bang-shun2;  PAN Yu-qin2;  WANG Shu-kui2
1. Clinical Medical School of Southeast University, Nanjing 210009, Jiangsu, China;2.Central Laboratory of Nanjing First Hospital Affiliated to Nanjing Medical University, Nanjing 210006，Jiangsu, China
关键词:
雌激素受体; 子宫内膜异位症; 基因多态性
Keywords:
Estrogen receptor; Endometriosis;  Gene polymorphism
分类号:
R711.71
DOI:
-
文献标志码:
A
摘要:
目的探讨雌激素受体α(estrogen receptor，ERα)基因多态性与子宫内膜异位症(endometriosis，EMs)发生的关系，从而了解EMs的发病因素，为疾病的早期诊断及预防提供实验依据。方法选取214例经手术及病理检查确认为EMs的患者作为观察组，选取健康体检者160例作为正常对照组。采用分子生物学的方法分析ERα的PvuⅡ、XbaⅠ酶切位点限制性片段长度多态性(restriction fragment length polymorphism，RFLP)，观察ERα基因多态性在观察组与对照组中的基因型分布。采用PCR-RFLP的方法分析雌激素受体的多态性。RFLP用Pp(Pvu Ⅱ)和Xx(Xba Ⅰ)来表示。结果XbaⅠ多态性在观察组与对照组中的分布存在显著性差异(P=0.002)。观察组X等位基因频率为26.17%，对照组为18.75%，两组间频率比较有显著性差异(P=0.002)；x等位基因频率为73.83%，对照组为81.25%，两组间频率比较有显著性差异(P=0.002)。其中X与x的比值比(OR)值为2.25(95%可信区间1.56～3.23)。PvuⅡ多态性在两组间分布比较，无显著性差异(P=0.081)，两组P与p等位基因频率分布比较，亦无显著性差异(P=0.069)。结论观察人群中X等位基因与EMs发病危险密切相关。
Abstract:
ObjectiveTo explore the association of gene polymorphisms of estrogen receptor with endometriosis, and provide the clues for early treatment after understanding of etiology of endometriosis.Methods214 patients with endometriosis pathologically diagnosed after operation, and 160 controls were enrolled into this study. PCR-RFLP with restriction enzyme Pvu Ⅱ and Xba Ⅰ was performed to identify the gene polymorphisms of estrogen receptor alpha, and the correlations of estrogen receptor alpha with endometriosis were then analyzed.ResultsThere was a significant difference between patients and controls(P=0.002) in the XbaⅠpolymorphism. The frequencies of allele X were 26.17% and 18.75%, and x were 73.83% and 81.25% in patients and controls respectively. The frequencies of allele X and x were significantly different between patients and controls(P=0.002).Compared with x, X allele had a higher OR value of 2.25 (95% CI between 1.56～3.23). There is no significant difference in Pvu Ⅱ polymorphism (P=0.081)，and no significant difference in the frequencies of P and p alleles between the patients and controls(P=0.069).ConclusionX allele is closely associated with a risk of occurrence of endometriosis.

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备注/Memo

备注/Memo:
南京市科技发展计划项目(200502019)
更新日期/Last Update: 2013-11-22