|本期目录/Table of Contents|

[1]叶长青,盛艳华,张 扬,等.原发性高血压患者脉压指数与尿微量 白蛋白的关系[J].医学研究与战创伤救治(原医学研究生学报),2008,10(05):340.
　YE Chang-qing,SHENG Yan-hua,ZHANG Yang,et al.Relationship between pulse pressure index and urine microalbum in patients with essential hypertension[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(05):340.
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原发性高血压患者脉压指数与尿微量 白蛋白的关系()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第10卷
期数:
2008年05期
页码:
340
栏目:
出版日期:
2008-09-20

文章信息/Info

Title:
Relationship between pulse pressure index and urine microalbum in patients with essential hypertension
文章编号:
1672-271X(2008)05-0340-03
作者:
叶长青; 盛艳华; 张 扬; 汪光正; 许 帅; 史有松
解放军第123医院心内科，安徽蚌埠 233015
Author(s):
YE Chang-qing;  SHENG Yan-hua;  ZHANG Yang;  WANG Guang-zheng;  XU Shuai;  SHI You-song
Department of Cardiology, the 123th Hospital of PLA, Bengbu 233015, Anhui，China
关键词:
原发性高血压; 脉压; 脉压指数; 尿微量白蛋白
Keywords:
Essential hypertension;  Pulse pressure;  Pulse pressure index;  Urine microalbum
分类号:
R544.1
DOI:
-
文献标志码:
A
摘要:
目的 探讨原发性高血压患者动态脉压及脉压指数与肾功能损害的相互关系。方法 对225例原发性高血压患者进行动态血压监测，计算研究对象的脉压和脉压指数，按脉压(＞60 mm Hg与≤60 mm Hg)和脉压指数(>0.45与≤0.45)进行分组，观察各组血尿素氮、肌酐、尿酸及尿微量白蛋白变化及其与脉压、脉压指数的相关性。结果 脉压>60 mm Hg组和脉压指数>0.45组上述肾功能指标中尿酸、尿微量白蛋白明显高于脉压≤60 mm Hg组和脉压指数≤0.45组；偏相关分析显示，尿微量白蛋白与收缩压(r=0.305,P＜0.05)、脉压(r=0.402, P＜0.01)和脉压指数(r=0.689, P＜0.01)呈正相关。结论 脉压指数能更灵敏的反映肾脏早期损害，是肾脏早期损害的重要危险因子。
Abstract:
Objective To investigate the relationship between dynamic pulse pressure (PP), pulse pressure index(PPI) and renal damage in patients with essential hypertension (EH). Methods The twenty-four hours′ ambulatory blood pressure (24 h ABP) was monitored in 225 patients with EH. The patients were divided into different groups according to the levels of ambulatory PP(APP)(≥61 mm Hg or ≤60 mm Hg) and PPI(≥0.46 or ≤0.45). The association of the blood BUN, UA, Cr and urine microalbum(UmAlb) with PP and PPI was analyzed. Results UmAlb and UA were significantly higher in PP≥61 mm Hg and PPI≥0.46 groups than that in PP≤60mmHg and PPI≤0.45 groups (P＜0.01). After adjustment for age, weight, body mass index (BMI) and diastolic blood pressure(DBP), there was a positive relationship between UmAlb and SBP(r=0.305, P＜0.05) and PP(r=0.402, P＜0.01) and PPI(r=0.689, P＜0.01).Conclusion There is a correlation between SBP, PP, PPI and UmAlb. PPI can sensitively predict the early renal impairment, and it′s the important risk factor of early renal impairment.

参考文献/References:

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[6]Cuspidi C,Macca G,Sampieri L,et al.Target organ damage and non-dipping pattern defined by two sessions of ambulatory blood pressure monitoring in recently diagnosed essential hypertensive patients[J]. J Hypertens,2001,19(9):1539-1545.
[7]Domanski M, Norman J, Wolz M,et al. Cardiovasculal risk assessment using pulse pressure in the first national health and nutrition examination survey(NHANES I)[J].Hypertention,2001,38(4):793-797.
[8]Langley-Evans SC, Langley-Evans AJ, Marchand MC. Nutr- itional programming of blood pressure and renal morphology[J]. Arch Physiol Biochem, 2003,111(1):8-16.
[9]Ibsen H, Olsen MH, Wachtell K, et al. Reduction in albumi- nuria translates to reduction in cardiovascular events in hypertensive patients: losartan intervention for endpoint reduction in hypertension study[J]. Hypertension,2005,45(2):198-202.
[10]杨鹏麟，徐定修，张素勤，等.脉压指数评价血管硬化的可行性探讨[J].中华心血管杂志,2002,30(6):334-337.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-11-22