|本期目录/Table of Contents|

[1]乔 飞,汪茂荣,隋云华,等.肝硬化患者循环高动力状态与肝肾综合征的关系探讨[J].医学研究与战创伤救治(原医学研究生学报),2008,10(06):418.
　QIAO Fei,WANG Mao-rong,SUI Yun-hua,et al.The relationship between hyperkinetic circulatory state and genesis of hepatorenal syndrome in patients with liver cirrhosis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(06):418.
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肝硬化患者循环高动力状态与肝肾综合征的关系探讨()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第10卷
期数:
2008年06期
页码:
418
栏目:
出版日期:
2008-11-20

文章信息/Info

Title:
The relationship between hyperkinetic circulatory state and genesis of hepatorenal syndrome in patients with liver cirrhosis
文章编号:
1672-271X(2008)06-0418-03
作者:
乔 飞; 汪茂荣; 隋云华; 何长伦
解放军第81医院传染科，江苏南京 210002
Author(s):
QIAO Fei; WANG Mao-rong; SUI Yun-hua; HE Chang-lun
Institute of Liver Disease,the 81th Hospital of PLA，Nanjing 210002,Jiangsu,China
关键词:
肝硬化; 肝肾综合征; 高动力循环
Keywords:
Liver cirrhosis; Hepatorenal syndrome; Hyperkinetic circulatory state
分类号:
R575.2
DOI:
-
文献标志码:
A
摘要:
目的 探讨肝硬化患者不同阶段循环功能的改变与肝肾综合征发生的关系。方法 对肝硬化拟行肝移植的46例患者进行了血液动力学指标的回顾性调查。将患者分为三组:肝硬化并发肝肾综合征组(A组)、肝硬化并发顽固性腹水组(B组)和肝硬化无并发症组(C组)。分别检测有创动脉收缩压、舒张压、肺动脉压、肺毛细血管锲压、左室舒张末容积、每搏量、射血分数等指标。结果 血流动力学表明，肝肾综合征组(A组)肺动脉压明显高于B和C组(P<0.01)，肺毛细血管锲压显著则低于B组和C组(P<0.05)。A组心脏每搏量、射血分数则显著低于B组(P<0.05)。门静脉流速有减缓趋势。结论 高动力循环功能失代偿可能是肝硬化患者发生肝肾综合征的重要因素之一；心功能的减退可能在Ⅱ型肝肾综合征发生中起了重要的转折作用。早期减轻高动力循环状态可能是防止肝肾综合征形成的关键。
Abstract:
Objective To investigate the relationship between the change of circutatory function during different phases of liver cirrhosis and the genesis of hepatorenal syndrome.Methods Retrospective study on blood circulatory function was made in 46 of patients with liver cirrhosis intended to have liver transplantation. All of the patients were divided into three groups: cirrhosis with the complication of hepatorenal syndrome (Group A), cirrhosis with refractory ascites (Group B) and simple cirrhosis with no complication (Group C). The vulnerarious systolic arterial pressure，diastolic pressure，pulmonary arterial pressure, pulmonary capillary wedge pressure，left ventricular end-diastolic volume，stroke volume and ejection fraction were also checked in the patients with liver cirrhosis in different phases．Results Haemodynamics results showed that pulmonary arterial pressure in Group A got much higher than that in Group B and C (P<0.01)，whereas pulmonary capillary wedge pressure (PCWP) in Group A were lower than that in Group B and C (P<0.05)．Stroke volume and ejection fraction in Group A were also lower than that in Group B (P<0.05)．The blood speed in portal vein of Group A was getting more slowly when compared with Group B and C．Conclusion Discompensation of hyperkinetic circulatory function might be an important factor results in hepatorenal syndrome in the patient with liver cirrhosis．The decrease of heart function could be a significant transition in the genesis of type Ⅱ HRS. Early reducing hyperkinetic circulatory state might be the good prevention for the patients from generation of hepatorenal syndrome．

参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-11-22