|本期目录/Table of Contents|

[1]丁雪燕,罗助荣.急性冠脉综合征血清脑钠肽水平及 阿托伐他汀对其影响[J].医学研究与战创伤救治(原医学研究生学报),2009,11(01):37-39.
　DING Xue-yan,LUO Zhu-rong.Levels of pro-B-type natriuretic peptide in patients with acute coronary syndrome and the effect of atorvastatin on them[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(01):37-39.
点击复制

急性冠脉综合征血清脑钠肽水平及 阿托伐他汀对其影响()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第11卷
期数:
2009年01期
页码:
37-39
栏目:
出版日期:
2009-01-20

文章信息/Info

Title:
Levels of pro-B-type natriuretic peptide in patients with acute coronary syndrome and the effect of atorvastatin on them
文章编号:
1672-271X(2009)01-0037-03
作者:
丁雪燕1; 罗助荣2
1.南京军区杭州疗养院海勤疗养区，浙江杭州 310002；2.南京军区福州总医院心内科，福建福州 350025
Author(s):
DING Xue-yan1; LUO Zhu-rong2
1.Naval Convalescent Zone,Hangzhou Sanatorium,Nanjing Military Command,Hangzhou 310002,Zhejiang,China；2.Department of Cardiology，Fuzhou General Hospital of Nanjing Military Command，PLA，Fuzhou 350025，Fujian，China
关键词:
急性冠脉综合征; 脑钠肽; 阿托伐他汀
Keywords:
Acute coronary syndrome; Pro-B-type natriuretic peptide; Atorvastatin
分类号:
R541.409
DOI:
-
文献标志码:
A
摘要:
目的 探讨血清脑钠肽(BNP)浓度差异对急性冠脉综合征(ACS)的临床意义及他汀类药物对ACS患者脑钠肽的影响。方法 以ACS患者78例和稳定型心绞痛患者(SAP)40例为研究对象,将ACS患者分为不稳定型心绞痛(UAP组)40例、急性心肌梗死(AMI组)38例，测定其血清脑钠肽(BNP)、高敏C反应蛋白 (CRP)、肌钙蛋白I(TnI) 水平;将ACS患者30例随机分为他汀治疗组(20例)和对照组(10例)，治疗4周后比较2组上述各指标的变化。结果 ACS组BNP、CRP、TnI水平均明显高于SAP组(P<0.01)，AMI组BNP、CRP、TnI水平均明显高于UAP组(P<0.01)，AMI组BNP水平与CRP正相关(r=0.913，P<0.01)、BNP水平与TnI正相关(r=0.526，P<0.01)；他汀组患者治疗后血清BNP、CRP水平较对照组下降幅度大(P<0.05)。结论 血清BNP水平与缺血的严重程度呈正相关。阿托伐他汀可显著降低急性冠脉综合征血清BNP水平。
Abstract:
Objective To explore clinical significance of serum levels of pro-B-type natriuretic peptide (BNP) in patients with acute coronary syndrome(ACS)and the effect of atorvastatin on them.Methods 78 cases of ACS and 40 cases of stable angina pectoris (SAP) were subjected to this study. ACS included acute myocardial infarction (AMI, n=38) and untable angina pectoris (UAP, n=40). The serum levels of BNP, CRP and TnI in all patients were measured. 30 patients with ACS were randomly divided into the atorvastatin treat group (n=20) and routine treat group (n=10). Levels of serum BNP, CRP, and TnI were measured four weeks after treatment in the two groups. Results Levels of serum BNP, CRP, and TnI were significantly higher in ACS group than in SAP group (P<0.01). Levels of serum BNP, CRP, and TnI were significantly higher in AMI group than in UAP group (P<0.01). BNP levels were highly correlated with TnI (r=0.526, P<0.01) and CRP(r=0.913, P<0.01). After administration for four weeks, the concentration of BNP, CRP, and TnI were deceased in atorvastatin group compared with routine group (P<0.05). Conclusion Serum level of BNP positively related with degree of myocardial ischemia. Atorvastatin could decrease the levels of BNP in ACS.

参考文献/References:

[1]Suzuki T, Yamazaki T, Yazaki Y. The role of the natriuretic peptidesin thecardiovascular system[J].Cardiovsc Res,2001,51:489-494.
[2]Galvani M. Ferrini D, Oani F. Natriuretic peptides for risk stratifica-tion of patients with acute coronary syndromes[J].Eur J Heart Fail,2004,6(3):327-333.
[3]Hama N,Itoh H,Shirakami G,et al.Rapid wentricular induct- ion of brain natriuretic peptide gene expressions in experimental acute myocardial infarction[J].Circulation，1995，92(6):1558-1564.
[4]黄伟光.冠心病病人N端前脑钠肽检测的临床意义[J].岭南心血管病杂志，2007，10(5):337-339.
[5]Mulvihill NT,Foley JB.Inflammation in acute coronary synd- romes[J].Heart,2002,87(6):201-204.
[6]祝赛敏.老年人无症状心肌缺血与肌钙蛋白I的关系[J].中国现代医学杂志，2000，10(2):26.
[7]王树岩.辛伐他汀对急性心肌梗死合并心房颤动患者的疗效观察[J].中华心血管杂志，2005，33(1):88.
[8]罗助荣. 急性冠状动脉综合征患者降胆固醇治疗对内皮依赖性血管舒张功能、血小板及纤溶活性的影响[J].中华心血管病杂志，2001，29(9):542-545. (收稿日期:2008-01-03；修回日期:2008-03-17)

相似文献/References:

[1]罗助荣,林 毅,张克己,等.福建地区汉族人群骨保护素基因rs2073617T/C多态性与急性冠脉综合征病变程度的关系[J].医学研究与战创伤救治(原医学研究生学报),2011,13(05):385.
　LUO Zhu-rong,LIN Yi,ZHANG Ke-ji,et al.Correlation between osteoprotegerin gene rs2073617T/C polymorphism and severity of acute coronary syndromes in Fujian area[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(01):385.
[2]罗助荣.骨保护素系统与动脉粥样硬化的研究进展[J].医学研究与战创伤救治(原医学研究生学报),2010,12(06):523.
[3]陈丽萍,陈 岩,张 强,等.瑞舒伐他汀序贯治疗对急性冠脉综合征患者血清缺血修饰清蛋白、C反应蛋白、髓过氧化物酶的影响[J].医学研究与战创伤救治(原医学研究生学报),2015,17(03):272.[doi:10.3969/j.issn.1672-271X.2015.03.015]
　CHEN Li-ping,CHEN Yan,ZHANG Qiang,et al.Rosuvastatin sequential therapy impact on IMA， CRP， MPO of patients with acute coronary syndrome[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(01):272.[doi:10.3969/j.issn.1672-271X.2015.03.015]
[4]王苏梦,吴 嘉,牛冬梅,等.急性冠脉综合征患者NT-proBNP、RDW和CRP的水平及相关性研究[J].医学研究与战创伤救治(原医学研究生学报),2015,17(04):362.[doi:10.3969/j.issn.1672-271X.2015.04.008]
　WANG Su-meng,WU Jia,NIU Dong-mei,et al.Study of plasma level of NT-proBNP, CRP and RDW in acute coronary syndrome patients[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(01):362.[doi:10.3969/j.issn.1672-271X.2015.04.008]
[5]章荣华,陈丞,邵先安,等.脑钠肽水平低于诊断阈值的终末期心衰患者的影响因素分析[J].医学研究与战创伤救治(原医学研究生学报),2022,24(6):608.[doi:10.3969/j.issn.1672-271X.2022.06.010]
　ZHANG Rong-hua,CHEN Cheng,SHAO Xian-an,et al.Analysis of risk factors in patients with end-stage heart failure whose brain natriuretic peptide level is below the diagnostic threshold[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2022,24(01):608.[doi:10.3969/j.issn.1672-271X.2022.06.010]

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2013-11-20