|本期目录/Table of Contents|

[1]吴述良,杨小宁,秦 玲.加巴喷丁超前镇痛在腹腔镜胆囊切除术中的应用[J].医学研究与战创伤救治(原医学研究生学报),2009,11(01):50-52.
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加巴喷丁超前镇痛在腹腔镜胆囊切除术中的应用()

《医学研究与战创伤救治》(原医学研究生学报)[ISSN:1672-271X/CN:32-1713/R]

卷:
第11卷
期数:
2009年01期
页码:
50-52
栏目:
出版日期:
2009-01-20

文章信息/Info

Title:
-
文章编号:
1672-271X(2009)01-0050-03
作者:
吴述良杨小宁秦 玲
解放军86临床部麻醉科,安徽当涂 243100
Author(s):
-
关键词:
加巴喷丁超前镇痛腹腔镜胆囊切除术
Keywords:
-
分类号:
R614.2
DOI:
-
文献标志码:
B
摘要:
目的 探讨加巴喷丁用于腹腔镜胆囊切除术的超前镇痛作用。方法 ASA I~Ⅱ级择期行腹腔镜胆囊切除术患者42例,随机分为两组,每组21例。对照组麻醉诱导前不用任何镇痛药,治疗组于手术开始前2 h口服加巴喷丁300 mg,分别于手术结束后2 h、4 h、12 h、24 h进行疼痛评分(VAS),同时记录两组患者术后初次使用哌替啶的时间、24 h内哌替啶使用总量及加巴喷丁的不良反应。结果 治疗组术后2 h、4 h、12 h、24 h VAS评分均低于对照组(P<0.01);术后初次使用哌替啶的时间长于对照组(P<0.01);治疗组术后24 h哌替啶使用总量小于对照组(P<0.01),两组的不良反应无显著性差异(P>0.05)。结论 加巴喷丁超前镇痛用于腹腔镜胆囊切除术,能有效缓解术后疼痛,减少术后哌替啶的使用量。
Abstract:
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参考文献/References:

[1]Carlton SM, Zhou S.Attenuation of formalin-induced nocicep- tive behaviors following local peripheral injection of gabapentin[J].Pain,1998,76(1-2):201-207.
[2]Field MJ,Oles RJ. Gabapentin(neurontin)and S-(+)-3-isob- utylgaba represent a novel class of selective antihyperalgesic agents[J].Br J Pharmacol,1997,121(8):1513-22.
[3]Shimoyama N, Shimoyama M, Davis AM, et al. Spinal gaba- pentin is antinociceptive in the rat formalin test[J]. Neurosci Lett,1997,222(1):65-67.
[4]Dahl JB, Moiniche S. Pre-emptive analgesia[J].Br Med Bull,2004,71(1):13-27.
[5]Beilin B. Effects of preemptive analgesia on pain and cytokine production in the postoperative period[J].Anesthesiology,2003,98(1):151-155.
[6]Ong CK,Lirk P,Seymour RA,et al.The efficacy of preemptive analgesia for acute postoperative pain management: a meta-analysis[J].Anesth Analg,2005,100(3):757-773.
[7]Karaaslan D,Sivaci RG,Akbulut G,et al.Preemptive analges- ia in laparoscopic cholecystectomy:a randomized controlled study[J].Pain Pract,2006,6(4):237-241.
[8]Lui PW,Lee CH.Preemptive effects of intrathecal cyclooxyge- nase inhibitor or nitric oxide synthase inhibitor on thermal hypersensitivity following peripheral nerve injury[J].Life Sci,2004,75(21):2527-2538.
[9]Walker MC, Patsalos PN. Clinical pharmacokinetics of new antiepileptic drugs[J]. Pharmacol Therap,1995,67(3):351-384.
[10]Werner MU, Perkins FM,Holte K,et al. Effects of gabape- ntin in acute inflammatory pain in humans[J].Reg Anesth Pain Med,2001,26(4):322-328.
[11]Eckhardt K,Ammon S,Hofmann U,et al. Gabapentin enhan- ces the analgesic effect of morphine in healthy volunteers[J].Anesth Analg,2000,91(1):185-191.
[12]Dooley DJ, Taylor CP, Donevan S, et al. D.Ca2+ channel alpha2delta ligands: novel modulators of neurotransmission[J].Trends Pharmacol Sci,2007 ,28(2):75-82.
[13]Maneuf YP,Luo ZD,Lee K.Alpha2delta and the mechanism of action of gabapentin in the treatment of pain[J].Semin Cell Dev Biol,2006,17(5):565-570.
[14]Sills GJ.The mechanisms of action of gabapentin and pregab- alin[J].Curr Opin Pharmacol,2006,6(1):108-113.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-11-20