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[1]祁 宾,卢 杰,宗 林,等.丙泊酚联合小剂量布托啡诺用于无痛 人工流产的效果观察[J].医学研究与战创伤救治(原医学研究生学报),2009,11(03):211-213.
　QI Bin,LU Jie,ZONG Lin,et al.Effect of propofol combined with small doses of butorphanol on painless artificial abortion[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(03):211-213.
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丙泊酚联合小剂量布托啡诺用于无痛 人工流产的效果观察()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第11卷
期数:
2009年03期
页码:
211-213
栏目:
出版日期:
2009-05-20

文章信息/Info

Title:
Effect of propofol combined with small doses of butorphanol on painless artificial abortion
文章编号:
1672-271X(2009)03-0211-03
作者:
祁 宾; 卢 杰; 宗 林; 张应祥; 王玉秀
解放军第82医院麻醉科，江苏淮安 223001
Author(s):
QI Bin; LU Jie; ZONG Lin; ZHANG Ying-xiang; WANG Yu-xiu
Department of Anesthesiology，the 82th Hospital of PLA，Huaian 223001,Jiangsu,China
关键词:
丙泊酚; 布托啡诺; 无痛人工流产
Keywords:
Propofol; Butorphanol; Painless artificial abortion
分类号:
R614.2+4
DOI:
-
文献标志码:
A
摘要:
目的 探讨丙泊酚联合小剂量布托啡诺用于无痛人工流产术可行性及其与现常用方法相比的优缺点。 方法 160例 ASAⅠ级早期妊娠患者随机分为四组，每组40例。A组(丙 泊酚+芬太尼组)静脉推注芬太尼0.001 mg/kg后推注丙泊酚；B组(丙泊酚组)直接静脉推注丙泊酚；C组、D组(丙泊酚+布托啡诺组)分别推注布托啡诺0.01 mg/kg和0.02 mg/kg后推注 丙泊酚。丙泊酚首剂量为B组2.5 mg/kg，其余各组2 mg/kg，术中出现肢体扭动者酌情追加丙泊酚30~50 mg。观察比较麻醉前后呼吸循环变化、麻醉镇痛效果、术后恢复情况及不良 反应等。结果 四组患者都成功完成手术。各组用药后均有一定的循环抑制，以 B组为著(P<0.05)。A组呼吸抑制发生率显著高于其他组(P<0.01)；B组术中镇痛不全和术后腹痛发生 率显著高于其他各组(P<0.05)；D组苏醒及离院时间显著长于A、B、C组(P<0.01)。结论 丙泊酚联合小剂量布托啡诺(0.01mg/kg)完全能满足无痛人工流产术麻醉需要，并较好地解 决单用丙泊酚所致镇痛不全和减少了加用芬太尼引起的呼吸抑制，值得推广应用于各类门诊小手术和无痛诊疗技术。
Abstract:
Objective To explore the feasibility as well as the advantages and disadvantages of propofol combined with small doses of butorphanol on painless abortion.Methods 160 cases of early-pregnant women with ASA (grade I) were randomly divided into four groups (40 cases each group). Patients in group A accepted 0.001 mg/kg fentanyl followed by propofol intravenously; Patients in group B accepted intravenous propofol; Patients in group C and D accepted 0.01 mg/kg or 0.02 mg/kg butorphanol before intravenous propofol respectively. The initial dose of propofol in group B was 2.5 mg/kg and 2 mg/kg in others, and additional doses will be applied when body motion occurred. The changes of respiratory and circulatory function, anesthesia and analgesia effects, postoperative recovery profile and side-effects were observed before and after anesthesia. Results The operations were successful in all the patients. Each group showed circulatory depression to a certain extent after anesthesia, and the most one was group B (P<0.05). The incidence of respiratory depression in group A was the highest (P<0.01). And the incidence of intraoperative insufficient analgesia and postoperative abdominal pain in group B was the most significant (P<0.05). In addition, the awake time and departure time was the longest in group D (P<0.05). Conclusion Propofol combined with small doses of butorphanol (0.01 mg/kg) can fulfill the requirement for painless artificial abortion. This anesthetic combination can decrease the incidence of insufficient analgesia and respiratory depression compared with using propofol or fentanyl alone. Therefore, it is suitable to apply anesthetic compatibility in the painless artificial abortion.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-11-20