|本期目录/Table of Contents|

[1]舒荣文,彭国林,朱人敏.败血症大鼠胃壁细胞形态和泌酸功能的 变化研究[J].医学研究与战创伤救治(原医学研究生学报),2009,11(06):515-517.
　SHU Rong-wen,PENG Guo-lin,ZHU Ren-min.The changes of gastric parietal cellular configuration in rats under sepsis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(06):515-517.
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败血症大鼠胃壁细胞形态和泌酸功能的 变化研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第11卷
期数:
2009年06期
页码:
515-517
栏目:
出版日期:
2009-11-20

文章信息/Info

Title:
The changes of gastric parietal cellular configuration in rats under sepsis
文章编号:
1672-271X(2009)06-0515-03
作者:
舒荣文1;  彭国林2; 朱人敏1
1.南京军区南京总医院，江苏南京 210002;2.解放军第184医院消化科，江西鹰潭 335000
Author(s):
SHU Rong-wen; PENG Guo-lin; ZHU Ren-min
1.Nanjing General Hospital of Nanjing Military Command,Nanjing 210002,Jiangsu,China;2.Department of Digestion,the 184th Hospital of PLA,Yingtan 335000,Jiangxi,China
关键词:
败血症; 大鼠; 应激; 胃酸; 胃壁细胞; H+/K+-ATP酶; 免疫荧光
Keywords:
Sepsis; Rats;  Stress ulcer;  Acid;  gastric; Parietal cell;  H+/K+-ATPase;  Immunofluorescence
分类号:
R631.3
DOI:
-
文献标志码:
A
摘要:
目的 研究败血症大鼠胃壁细胞形态和泌酸功能的变化，探讨胃酸在败血症胃黏膜损伤中的作用。方法 制作大鼠败血症模型，测定胃液pH值、胃溃疡指数UI，用激光共聚焦扫描显微镜观察壁细胞形态。结果 败血症24 h、48 h组胃液pH值较对照组显著降低，大鼠胃UI显著高于对照组，败血症大鼠分泌期壁细胞数显著高于对照组。败血症大鼠胃液pH值与胃UI无明显相关，胃液pH值与分泌期壁细胞数呈负相关。结论 败血症可引起胃黏膜损伤、出血，从细胞学水平证明了败血症后胃酸分泌增多，但胃黏膜损伤严重程度与胃液pH不相关，胃酸只是败血症引起应激性溃疡的病因之一。
Abstract:
Objective To assess the changes of gastric parietal cellular configuration in rats under sepsis and try to elucidate the role of acid in the stress ulceration. Methods and methods The rat models of sepsis were made. The gastric pH value was measured and the gastric ulcer index (UI) was evaluated. The morphology of parietal cells was observed using Immunofluoresence with confocal laser scanning microscope (CLSM). Results Gastric pH value of intact rats was negatively correlated with UI. The gastric pH value in sepsis 24h rats and sepsis 48h rats were significantly lower than that of control groups. The gastric pH value in sepsis 48h rats was no different to that in sepsis 24h. The gastric UI in sepsis 24h rats were significantly higher than that in control groups. The gastric UI value in sepsis 48h rats was significantly higher than that in sepsis 24h rats. Gastric pH value of sepsis rats was not correlated with UI and negatively correlated with the number of secreting parietal cells UI. The number of secreting parietal cells in both groups was significantly more than that in intact rats. Conclusion Rats under sepsis developed gastric mucosal lesions and increased acid secretion. The severity of gastric mucosal lesions was not correlated with gastric pH value. Gastric acid is one of reasons that induce stress ulcer by sepsis.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-11-20