|本期目录/Table of Contents|

[1]徐 萍,唐永明.端粒酶活性在胃癌组织中表达的临床意义[J].医学研究与战创伤救治(原医学研究生学报),2009,11(06):518-519，522.
　XU Ping,TANG Yong-ming.The clinical significance of expression of telomerase in gastric cancer[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(06):518-519，522.
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端粒酶活性在胃癌组织中表达的临床意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第11卷
期数:
2009年06期
页码:
518-519，522
栏目:
出版日期:
2009-11-20

文章信息/Info

Title:
The clinical significance of expression of telomerase in gastric cancer
文章编号:
1672-271X(2009)06-0518-03
作者:
徐 萍; 唐永明
解放军第454医院消化科，江苏南京 210002
Author(s):
XU Ping;  TANG Yong-ming
The 454th Hospital of PLA， Nanjing 210002,Jiangsu,China
关键词:
端粒酶; 胃癌; 表达
Keywords:
Telomerase;  Gastric cancer;  Expression
分类号:
R735.2
DOI:
-
文献标志码:
A
摘要:
目的 研究胃癌组织中端粒酶的活性表达。方法 采用端粒酶重复序列扩增法。结果 胃癌组织中端粒酶活性表达阳性率达91%。正常胃黏膜组织中未检出端粒酶活性。两者有显著性差异(P<0.001)。胃癌组织不同分化程度及淋巴结转移之间端粒酶活性阳性率未发现显著差异(P＞0.05)。结论 端粒酶参与各型不同分化程度胃癌的发生,在胃癌组织中高度表达,而在正常组织中不表达，有助于提高早期胃癌的检出率。
Abstract:
Objective To study the expressing of telomerase in gastric cancer and its clinical significance. Methods Repeated sequence amplification assay was used to detect telomerase activity. Results Telomerase activity was detected in 91% gastric cancer tissues while not detected in normal gastric mucosas. There was significant difference between them (P<0.001). No significantly different expression of telomerase in differentiation and lymph node metastasis between gastric cancer and normal mucosa was found. Conclusion Telomerase activity is a universal event in differentiation of gastric cancer. Telomerase is over expression in gastric cancer and no expression in normal tissue, which is helpful in the early diagnosis of gastric cancer.

参考文献/References:

[1]于志坚.胃癌防治研究新进展[J].交通医学，2007，21(3):225-225.
[2]王福生.3427例胃癌临床资料分析[J].胃肠病学和肝病学杂志,2006,15(1):40-41.
[3]姚伟明,王 波，姒健敏. 端粒酶与胃癌相关性研究进展[J].实用肿瘤学杂志，2007，21(1):92-94.
[4]王旭霞，张盈华，郝晓柯，等. 端粒活性检测在胃癌诊断中的应用及其意义[J]. 解放军第四军医大学学报，2002，12(3):12-13.
[5]龙 军，付曲波，黄才斌，等. 端粒、端粒酶及其基因转录调控与肿瘤[J]. 赣南医学院学报,2008, 28(3):467-468.
[6]Yang Si-ming,Fang Dian-chun,Luo Yuan-hui,et al .Alterations of telomerase activity ang terminal restriction fragment in gastric cancer and its premalignant lesions[J].J Gastroentrol Hepatol,2001,16(8):876-882.
[7]Matsutani N，Yokozaki H，TahBra E，et al.Expression of MREll complex (MRE11，RAD50，NBSI)and hrap1 anditsrelation with telomere regulation，telomerase activity in human gastric carcinomas [J] .Pathobiology，2001，69:219-222.
[8]Hiyama E,Okoyama T,Tatsumoto N,et al.Telomerase activity in gastric cancer[J]. Cancer Res,1995,55(15):3258.
[9]KuniyasuH ,Kitadai Y,Mieno H,et al .Helicobactor pyloriinfection is closely associatedwithtelonmere reduction in gastricumcosa[J].Oncology,2003,65(3):275-282.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-11-20