|本期目录/Table of Contents|

[1]张 缨,李祥周,乐美兆,等.肺隐球菌病超微结构观察[J].医学研究与战创伤救治(原医学研究生学报),2010,12(01):24-26.
　ZHANG Ying,LI Xiang-zhou,LE Mei-zhao,et al.Ultrastructural observation of pulmonary cryptococcosis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(01):24-26.
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肺隐球菌病超微结构观察()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年01期
页码:
24-26
栏目:
出版日期:
2010-01-20

文章信息/Info

Title:
Ultrastructural observation of pulmonary cryptococcosis
文章编号:
1672-271X(2010)01-0024-03
作者:
张 缨1 ; 李祥周1; 乐美兆1 ; 姜少军2; 周晓军2
1.210002江苏南京， 解放军81医院病理科；2. 210002江苏南京，南京军区南京总医院病理科
Author(s):
ZHANG Ying1;  LI Xiang-zhou1;  LE Mei-zhao1;  JIANG Shao-jun2;  ZHOU Xiao-jun2.
1.Department of Pathology，81 Hospital of PLA；2.Department of Pathology，Nanjing General Hospital of Nanjing Military Command，PLA，Nanjing，Jiangsu 210002，China
关键词:
肺疾病; 隐球菌病; 超微结构
Keywords:
lung disease;  cryptococcosis;  ultrastructure
分类号:
R563；R519.4
DOI:
-
文献标志码:
A
摘要:
目的 观察肺隐球菌病的超微结构特征。方法 对17例肺隐球菌病患者的病变组织进行光镜和透射电镜观察。结果 光镜下，见非干酪性肉芽肿形成，多核巨细胞和巨噬细胞胞质内及间质中可见薄壁圆形或卵圆形空泡状小体，黏液卡红和PAS染色呈阳性。透射电镜下，隐球菌无菌丝，单细胞芽生，孢子无子囊，有荚膜形成，荚膜与细胞壁之间有明显透明带，结构较简单，细胞器不发达。结论 肺隐球菌病是由新型隐球菌感染引起的一种非常少见的肺部真菌病，其临床及影像学表现缺乏特异性，超微结构形态学特征可反映其独有的生物学特点，具有协助临床诊断的意义。
Abstract:
Objective To study the ultrastructural characteristics of pulmonary cryptococcosis(PC). Methods Tissues obtained from 17 patients with PC were observed by light microscope and electron microscope. Results Microscopically, the cryptococcosis granuloma formation was observed. Vacuolar cryptococcus spore could be seen in plasma of multinuclear giant cell, macrophage and mesenchyma, which stained in red color with PAS and mucicarmine. Electron microscopy revealed that most of cryptococcus neoformans(CN) had a simple structure with a few organelles. The capsule was seen in all organisms. Gemmation of CN could be observed. Conclusion PC is an infrequent fungal disease in lung. The clinical manifestation and imaging of PC are nonspecific. It can be differentiated from other diseases based on histopathological features and ultrastrual observation.

参考文献/References:

[1] 易祥华，孔 洁，朱美芳，等. 原发性肺隐球菌病的病理诊断和超微结构观察[J]. 中华病理学杂志，2004，33(5):424-428.
[2] Shibuya K，Hirata A，Omuta J，et al. Granuloma and cryptococcosis[J]. J Infect Chemother，2005，11(3):115-122.
[3] Lortholary O，Nunez H，Brauner MW，et al. Pulmonary cryptococcosis[J]. Semin Respir Crit Care Med，2004，25(2):145-157.
[4] Yang CJ，Hwang JJ，Wang T H，et al. Clinical and radiographic presentations of pulmenary cryptococcosis in immunocompetent patients[J]. Scand J Infect Dis，2006，38(9):788-793.
[5] Hung MS，Tsai YH，Lee CH，et al. Pulmonary cryptococcosis: Clinical, radiographical and serological markers of dissemination[J]. Respirology，2008，13(2):247-251.
[6] 张 缨，宗晓福，李祥周，等. 肺隐球菌病17例临床病理分析[J]. 临床与实验病理学杂志，2009，25(5):485-488.
[7] Shirley R，Baddley JW. Cryptococcal lung disease[J]. Curr Opin Pulm Med，2009，15(3):254-260.
[8] Chu HQ，Li HP，He GJ，et al. Analysis of 23 cases of pulmonary cryptococcosis[J]. Chin Med J，2004，117(9):1425-1427.

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备注/Memo

备注/Memo:
-
更新日期/Last Update: 2010-01-20