|本期目录/Table of Contents|

[1]史 跃,王安明,陈启忠,等.动脉溶栓联合自体骨髓间充质干细胞治疗股骨头坏死[J].医学研究与战创伤救治(原医学研究生学报),2010,12(01):27-29.
　SHI Yue,WANG An-ming,CHEN Qi-zhong,et al.Treatment for femoral head necrosis by combining arterial thrombolysis with marrow mesenchymal stem cells[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(01):27-29.
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动脉溶栓联合自体骨髓间充质干细胞治疗股骨头坏死()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年01期
页码:
27-29
栏目:
出版日期:
2010-01-20

文章信息/Info

Title:
Treatment for femoral head necrosis by combining arterial thrombolysis with marrow mesenchymal stem cells
文章编号:
1672-271X(2010)01-0027-03
作者:
史 跃1; 王安明1; 陈启忠2; 朱丽丽1; 刘军权3; 丁 凯4; 高从敬1
221004江苏徐州，解放军97医院，1. 医学影像科，2.急诊科，3.实验科，4.血液科
Author(s):
SHI Yue1;  WANG An-ming1;  CHEN Qi-zhong2;  ZHU Li-li1;  LIU Jun-quan3;  DING Kai4;  GAO Cong-jing1.
1.Department of Radiology；2. Department of Emergency；3.Department of Medical Laboratory；4.Department of Hematology,97 Hospital of PLA, Xuzhou,Jiangsu 221004, China
关键词:
股骨头缺血性坏死; 骨髓间充质干细胞; 动脉灌注; 数字减影血管造影; 介入治疗
Keywords:
femoral head avascular necrosis;  mesenchymal stem cells;  arterial perfusion;  digital subtraction angiography;  interventional treatment
分类号:
R681.8
DOI:
-
文献标志码:
A
摘要:
目的 探讨经动脉溶栓联合自体骨髓间充质干细胞(MSC)灌注介入治疗股骨头缺血性坏死的疗效。方法 观察组30例股骨头坏死患者采用seldinger技术，经皮-股动脉穿刺将导管选至股骨头供养动脉，灌注脲激酶40万U，罂栗硷30 mg。然后经旋股内动脉灌注MSC悬液20 ml, MSC数量约为1×107～1×108个。并与同期单纯采用动脉溶栓介入治疗34例作比较。结果 观察组股骨头、颈区域狭窄闭塞血管再通，股骨头血管染色区域明显增大，坏死区域逐渐缩小29例。观察组治疗前后关节活动度比较有显著性差异(P＜0.01)，观察组有效率及临床治愈率均高于对照组。结论 经动脉溶栓后灌注自体骨髓间充质干细胞治疗股骨头缺血性坏死可以提高疗效。
Abstract:
Objective To explore the effect of arterial interventional thrombolysis combining with injection of autologous bone marrow mesenchymal stem cells(MSC) on the treatment for avascular necrosis of the femoral head (ANFH). Methods By using the seldinger technique, the catheter was introduced to the supplying artery of the femoral head through the femoral artery on 30 patients of ANFH . Urokinase 4×105 U and papaverine 30mg were injected into the supplying artery, and 1×107～1×108 MSC were injected into the femoral circumflex artery. 34 patients of ANFH who received arterial interventional thrombolysis only were used as controls. Results The stenosis and obstruct vessel of the femoral head and neck area in 29 studied patients were revascularized, in which the area of vessel staining of the femoral head increased obviously and necrosis area of the femoral head gradually decreased. The range of motion of the joint was significantly different before and after treatment (P＜0.01). The efficiency and cure rate of the study group were higher than that of controlled group. Conclusion It is feasible to treat ANFH by arterial interventional thrombolysis combining with injection of autologous bone marrow mesenchymal stem cells.

参考文献/References:

[1] 赵德伟.股骨头缺血坏死的修复与再造[M].北京:人民卫生出版社，1998:19-48.
[2] 杨晓凤，王红梅，许忆峰，等.经动脉骨髓干细胞移植治疗股骨头坏死63例[J].中国临床康复，2006，10(13):3-5.
[3] 张孟增，刘沧君，路志福，等.骨髓内减压与加压注药在成人股骨头坏死中的应用[J].实用放射学杂志，2001，17(5):369-371.
[4] Gangji V, Hauzeur JP, Schoutens A, et al. Abnormalities in the replicative capacity of osteoblasitic cells in the proximal femur of patients with osteonecrosis of the femoral head[J].J Rheumatol,2003,30(2):348-351.
[5] Xu WR, Qian H, Zhu W, et al. Anorel tumor cell line cloned from mutated human embryonic bone morrow mesenchymal stem cells[J] .Oncology Reports, 2004,12(3):501-508.
[6] Hernigou P, Beaujean F. Treatment of osteonecrosis with autologous bone marrow grafting[J]. Clin Orthop, 2002,405(1):14-23.
[7] Ganji V, Hauzeur JP, Matos C. Treatment of osteonecrsis of the femoral head with implantation of autologous bone marrow cells[J] . Bone Joint Surg Am, 2004,86(6):1153-1160.
[8] Mont MA, Jones LC, Hungerford DS. Nontraumatic osteonecrosis of the femoral head: ten years later[J].J Bone Joint Surg Am, 2006,88(5):1117-1132.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2010-01-20