|本期目录/Table of Contents|

[1]佟波涛,王 品,赵建生.围术期应用氟比洛芬酯对舒芬太尼用于妇科肿瘤术后镇痛的影响[J].医学研究与战创伤救治(原医学研究生学报),2010,12(02):117-119.
　TONG Bo-tao,WANG Pin,ZHAO Jian-sheng..The effects of analgesia with flurbiprofen axeyil injection combined with sufentanil in perioperative period of patients with gynecological carcinoma[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(02):117-119.
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围术期应用氟比洛芬酯对舒芬太尼用于妇科肿瘤术后镇痛的影响()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年02期
页码:
117-119
栏目:
出版日期:
2010-03-20

文章信息/Info

Title:
The effects of analgesia with flurbiprofen axeyil injection combined with sufentanil in perioperative period of patients with gynecological carcinoma
文章编号:
1672-271X(2010)02-0117-03
作者:
佟波涛; 王 品; 赵建生
210002 江苏南京，解放军81医院麻醉科
Author(s):
TONG Bo-tao; WANG Pin; ZHAO Jian-sheng.
Department of Anesthesiology, 81 Hospital of PLA，Nanjing，Jiangsu 210002，China
关键词:
围术期; 凯纷; 舒芬太尼; 术后静脉镇痛
Keywords:
perioperative;  flurbipmfen axeyil;  sufentanyl;  patient-conrolled intravenous analgesia
分类号:
R614.2+4
DOI:
-
文献标志码:
A
摘要:
目的 观察围术期应用凯纷(氟比洛芬酯)对舒芬太尼用于妇科肿瘤手术后静脉自控镇痛(PCIA)的镇痛效果及安全性。方法 选取妇科肿瘤择期手术患者(美国麻醉医师协会术前体格评估Ⅰ～Ⅲ级)90例，随机分成3组。A组30例，术前10分钟静注凯纷1 mg/kg，术后给予凯纷50 mg+舒芬太尼1.5 μg/kg加生理盐水至100 ml；B、C两组术前均不给凯纷，B组术后给予舒芬太尼1.5 μg/kg加生理盐水至100 ml；C组术后给予舒芬太尼2 μg/kg加生理盐水至100 ml。背景剂量2 ml/h，冲击剂量2 ml，锁定时间15 min。手术结束前10 min给予首次剂量舒芬太尼5 μg+欧贝8 mg，手术结束时接泵。观察术后1、4、12、24、48 h的视觉模拟疼痛评分，舒芬太尼总用量、PCIA使用次数及不良反应的发生情况。 结果 3组患者术后均未发生呼吸、循环系统严重并发症，组间无显著差异(P>0.05)；术后视觉模拟疼痛评分(VAS)、PCIA使用次数，B组明显高于A、C组(P<0.05)。C组患者术后恶心、呕吐、头晕、头痛等的发生率明显高于A、B组(P<0.01)。结论 围术期应用凯纷可明显增强舒芬太尼用于妇科肿瘤手术PCIA中的镇痛效果，并减少舒芬太尼的总药量和术后不良反应。
Abstract:
Objective To study the effects of postoperative analgesia and safety with flurbiprofen axeyil injection combined with sufentanil in patients undergoing gynecological carcinoma. Methods 90 cases of ASA (American Society of Anesthesiologists) I～Ⅲ level patients who received patient-conrolled intravenous analgesia (PCIA)，scheduled for gynecological carcinoma were randomly divided into three groups equally. Group A was administrated injection flurbiprofen axeyil 1 mg/kg before the operation and injection another flurbiprofen axeyil 50 mg at the end of operation, then with sufentanil 1.5 μg/kg, group B with sufentanil 1.5 μg/kg and group C with sufentanil 2.0 μg/kg. The drugs in both groups were diluted to 100 ml and infused by a pump at a rate of 2 ml/h with a patient-controlled bolus of 2 ml, and locked-time of 15 minutes. Injection of sufentanil 5 μg puls ondansetron 8 mg was conducted at 10 minutes to the end of operation. The visual analog scale (VAS)，times of PCIA and incidence of side effects were recorded at 1h，4h，12h，24h，48h after operation. Results There was no significant difference in the three groups in surgery duration(P>0.05). VAS B >VSA A,C; The times of the PCIA 24 hr after operation in group B were significantly more than group A and C(P<0.05). The accidences of nausea, vomiting, itching, somnolence in group C were significantly more than in group A and B(P<0.01). Conclusion Postoperative analgesia with flurbiprofen axeyil injection combined with sufentanil can reduce sufentanil requirement and its side effects.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2010-03-20