|本期目录/Table of Contents|

[1]王 燕,吕 华,邵坤泉,等.三种药物治疗阵发性心房颤动的疗效对比[J].医学研究与战创伤救治(原医学研究生学报),2010,12(03):232-234.
　WANG Yan,LV Hua,SHAO Kun-quan,et al.Observation of therapeutic effects of three drugs on paroxysmal atrial fibrillation[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(03):232-234.
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三种药物治疗阵发性心房颤动的疗效对比()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第12卷
期数:
2010年03期
页码:
232-234
栏目:
出版日期:
2010-05-20

文章信息/Info

Title:
Observation of therapeutic effects of three drugs on paroxysmal atrial fibrillation
文章编号:
1672-271X(2010)03-0232-03
作者:
王 燕; 吕 华; 邵坤泉; 金旭青; 刘海鹰; 张必初
310006 浙江杭州,浙江省军区第四干休所医务室
Author(s):
WANG Yan; LV Hua; SHAO Kun-quan; JIN Xu-qing; LIU Hai-ying; ZHANG Bi-chu
Medical Affairs Room，the Four Cadre Relaxation Club，Hangzhou,Zhejiang 310006，China
关键词:
心房颤动; 普罗帕酮;  胺碘酮; 美托洛尔
Keywords:
atrial fibrillation;  propafenone;  admiodarane;  metoprolol
分类号:
R541.75
DOI:
-
文献标志码:
A
摘要:
目的 对比观察普罗帕酮、胺碘酮、美托洛尔治疗阵发性心房颤动(PAF)的疗效和安全性。方法 对80例阵发性心房颤动患者随机分组使用普罗帕酮(32例)、胺碘酮(28例)、美托洛尔(20例)治疗。结果 三组患者服药后48小时内有效率分别为72%、75%、65%，组间比较均无统计学意义(P>0.05)；不同年龄组之间的有效率均无统计学意义(P>0.05)。三组药物的不良反应发生率分别为16%、14%、15%，均无统计学意义(P>0.05)；未见严重毒副反应及致心律失常作用。结论 三种药物治疗PAF均有较好疗效，且相对安全。
Abstract:
Objective To investigate the efficacy and safety of propafenone, admiodarane, metoprolol and tartrate capsules (Betaloc) in treating and preventing of paroxysmal atrial fibrillation (PAF). Methods 80 patients with atrial fibrillation were randomly divided into propafenone (n=32), admiodarane (n=28) and metoprolol group (n=20). Results The recovery rates within 48 hours after treatment in propafenone, admiodarane and metoprolol group were 72%, 75% and 65% respectively. No significant difference was found in three groups (P>0.05). There was no significant difference among different age groups (P>0.05). The occurrence rates of adverse reactions in the propafenone, admiodarane and metoprolol group were 16%, 14% and 15% respectively. There was no significant difference (P>0.05). No serious side effect or arrhythmia was found. Conclusion Three drugs are effective and relatively safe in the treatment and prevention of the relapse of PAF.

参考文献/References:

[1] 周自强，胡大一，陈 捷，等.中国心房颤动现状流行病学研究[J].中华内科杂志,2004，43(7):491-494.
[2] 杨成奎, 王惜诵, 靳海东,等.胺碘酮、普罗帕酮、美托洛尔治疗阵发性室上性心动过速疗效观察[J]. 临床合理用药杂志，2009，2(6):1-2.
[3] Fuster V, Ryden LE,Cannom DS,et al.ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and the European Society of Cardiology Committee for practice guidelines:developed in collaboration with the European Heart Rhythm Association and the Heart Rhythm Society[J].Circulation，2006,114(7):e257-e354.
[4] Zimetbaum P. Am iodarone for atrial fibrillation[J].N Engl J Med，2007,356(9):935-941.
[5] 杨延宗.胺碘酮在心房颤动治疗中的应用[J]. 中华心血管病杂志，2009, 37(6):561-562.
[6] 陈则君.美托洛尔对慢性心力衰竭并快速房颤的疗效及机制[J].临床医学，2008，28(11):67-69.
[7] 夏金明,邵 兰.长期口服胺碘酮致肺纤维化[J].临床误诊误治，2007,20(10):96-96.
[8] 徐 耘. 胺碘酮致亚临床甲状腺功能减退47例回顾性分析[J]. 医药导报，2009，8(8):1098-1098.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2010-05-20