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[1]洪原城,黄鑫成,黄种杰,等.老年肺真菌感染患者检测葡聚糖的临床意义[J].医学研究与战创伤救治(原医学研究生学报),2011,13(01):28-30.
　HONG Yuan-cheng,HUANG Xin-cheng,HUANG Zhong-jie,et al.Clinical significance of glucan detection for pulmonary fungal infection in elderly patients[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(01):28-30.
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老年肺真菌感染患者检测葡聚糖的临床意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年01期
页码:
28-30
栏目:
出版日期:
2011-01-20

文章信息/Info

Title:
Clinical significance of glucan detection for pulmonary fungal infection in elderly patients
文章编号:
1672-271X(2011)01-0028-03
作者:
洪原城; 黄鑫成; 黄种杰; 范洪涛
362000 福建泉州，解放军180医院心肾呼吸科
Author(s):
HONG Yuan-cheng; HUANG Xin-cheng; HUANG Zhong-jie; FAN Hong-tao
Department of Pneumology, 180 Hospital of PLA, Quanzhou,Fujian 362000,China
关键词:
肺真菌感染; (1→ 3)-β-D葡聚糖; 老年患者
Keywords:
pulmonary fungal infection;  (1→3)-β-D glucan;  elderly patients
分类号:
R379
DOI:
-
文献标志码:
A
摘要:
目的 探讨检测葡聚糖对肺真菌感染老年患者的临床意义。方法 真菌性肺部感染患者31例(A组)、混合性肺部感染(真菌+细菌)患者15例(B组)、细菌性肺感染患者35例(C组)、健康老年人35例(D组)，应用MB-80微生物快速动态检测系统和真菌(1→ 3)-β-D 葡聚糖检测试剂盒检测各组血浆(1→ 3)-β-D葡聚糖含量。结果 A组、B组、C组、D组血浆(1→ 3)- β-D葡聚糖含量分别为(56.23±11.77)pg/ml、(56.99±12.87)pg/ml、(8.39±2.12)pg/ml、(8.05±2.02)pg/ml。A组与B组比较、C组与D组比较无显著差异(P>0.05)；A组(B组)与C组(D组)比较均有显著差异(P<0.01)。结论 血浆(1→ 3)-β-D葡聚糖水平是早期诊断老年肺真菌感染患者的指标之一。
Abstract:
Objective To study the clinical significance of glucan detection for pulmonary fungal infection in elderly patients. Methods Patients with pulmonary fungus infection (n=31, group A), patients with pulmonary mixed infection (fungi + bacteria, n=15, group B), patients with pulmonary bacterial infection (n=35, group C), and the healthy elderly control (n=35, group D) were enrolled in this study. The plasma content of (1→3)-β-D glucan was detected using MB-80 microbial fast dynamic testing system and fungi (1→ 3) β-D glucan kit. Results Plasma (1→3)-β-D glucan content of Group A, group B, group C and group D were 55.23±11.77 pg/ml, (56.99±12.87)pg/ml, (8.39±2.12)pg/ml, and (8.05±2.02)pg/ml respectively. No significant difference was detected between Group A and B group, and between group C and D group (P>0.05). There was a statistical difference between Group A(group B and Group C(group D) (P<0.01). Conclusion The level of plasma (1→3)-β-D glucan was an index of early diagnosis for elderly patients with pulmonary fungus infection.

参考文献/References:

[1]Hope WW, Petraitis V, Petraitiene R，et al. The initial 96 hours of invasive pulmonary aspergillosis: histopathology, comparative kinetics of galactomannan and (1→3) β-d-glucan and consequences of delayed antifungal therapy[J］. Antimicrob Agents Chemother， 2010，54(11):4879-4886.
[2］Koo S, Bryar JM, Page JH, et al. Diagnostic performance of the (1→3)-beta-D-glucan assay for invasive fungal disease[J］. Clin Infect Dis，2009，49(11):1650-1659.
[3］刘佳庆，张丽霞，刘 雅，等.(1，3 )-β-D葡聚糖在侵袭性肺部真菌感染的诊断价值[J］. 中国医学检验杂志，2010,11(1):10-12.
[4］Metan G, Agkus C, Buldu H, et al. The interaction between piperacillin/tazobactam and assays for Aspergillus galactomannan and 1,3-beta-D-glucan in patients without risk factors for invasive fungal infections[J］. Infection，2010,38(3):217-221.
[5］Koo S, Bryar JM, Page JH, et al. Diagnostic performance of the (1→3)-beta-D-glucan assay for invasive fungal disease[J］. Clin Infect Dis，2009,9(11):1650-1659.
[6］Jia W,Li YC,Zhu YQ,et al. The clinical efficacy and cardiac safety of itraconazole injection in treatment of acute pulmonary invasive fungal infection in chronic pulmonary diseases in the elderly[J］.Zhonghua Nei Ke Za Zhi，2010，49(3):230-233.
[7］杨 芳，魏宗赛, 叶小兰. 某医院深部真菌感染调查分析[J］. 东南国防医药，2009,11(5):423-424.
[8］Guery BP, Arendrup MC, Auzinger G，et al. Management of invasive candidiasis and candidemia in adult non-neutropenic intensive care unit patients: Part I. Epidemiology and diagnosis[J］. Intensive Care Med，2009，35(1):55-62.
[9］Del Palacio A, Cuétara MS, Llenas-García J, et al. Serum (1→3)-{beta}-D-Glucan assay for the diagnosis of Pneumocystis jiroveci pneumonia[J］. Clin Vaccine Immunol，2010，17(1):202-203.
[10］Racil Z, Kocmanova I, Lengerova M, et al. Difficulties in using 1,3-{beta}-D-glucan as the screening test for the early diagnosis of invasive fungal infections in patients with haematological malignancies-high frequency of false-positive results and their analysis[J］.J Med Microbiol，2010，59(9):1016-1022.

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更新日期/Last Update: 2011-01-20