|本期目录/Table of Contents|

[1]黄学忠,林佩佩,陈晓飞.1385株临床流行菌株调查及耐药分析[J].医学研究与战创伤救治(原医学研究生学报),2011,13(03):219-222.
　HUANG Xue-zhong,LIN Pei-pei,CHEN Xiao-fei..Investigation of the clinical popular strain and drug-resistance in 1385 cases[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2011,13(03):219-222.
点击复制

1385株临床流行菌株调查及耐药分析()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第13卷
期数:
2011年03期
页码:
219-222
栏目:
出版日期:
2011-05-20

文章信息/Info

Title:
Investigation of the clinical popular strain and drug-resistance in 1385 cases
文章编号:
1672-271X(2011)03-0219-04
作者:
黄学忠; 林佩佩; 陈晓飞
325000 浙江温州，解放军113医院118临床部
Author(s):
HUANG Xue-zhong; LIN Pei-pei; CHEN Xiao-fei.
118 Clinical Branch of 113 Hospital,PLA,Wenzhou,Zhejiang 325000,China
关键词:
细菌; 耐药性; 金黄色葡萄球菌; 铜绿假单胞菌
Keywords:
bacteria;  resistance;  staphylococcus aureus;  pseudomonas aeruginosa
分类号:
R446.51
DOI:
-
文献标志码:
A
摘要:
目的 分析我院2005年至2009年近5年间临床流行菌株及耐药谱的变化，为指导临床控制院内感染和合理使用抗菌药物提供参考。方法 用Excel软件从LIS数据库中采集同期本院住院患者送检标本中分离的所有菌株共1385株。菌株鉴定和药敏试验采用ATB Expression细菌鉴定系统和药敏板条，并进行统计分析。结果 近5年间院内感染以金黄色葡萄球菌和铜绿假单胞菌为主，而鲍氏不动杆菌检出率呈逐年递增趋势。在创面分泌物、血液和静脉留置针中，以金黄色葡萄球菌占优势，而尿液和痰标本则分别以大肠埃希菌和铜绿假单胞菌为主。不同标本分离的铜绿假单胞菌对同种抗菌药物敏感性差异显著，痰标本分离株对美洛培南、亚胺培南、替卡西林、哌拉西林、替卡西林/克拉维酸、哌拉西林/他唑巴坦、头孢他啶的耐药率远高于创面分泌物标本。结论 引起院内感染的主要菌株为革兰阳性金黄色葡萄球菌和革兰阴性铜绿假单胞菌。痰标本分离的铜绿假单胞菌株对碳青霉烯类、抗假单胞菌类、β-内酰胺酶复合抑制剂类和Ⅲ代头孢的耐药率高于创面分泌物分离株。
Abstract:
Objective To impart reference on directing clinical control nosocomial infection and reasonably using antibiotics, the alteration on clinical popular strain and drug resistance spectrum between 2005 and 2009 were analyzed. Methods Using self-made Excel software, 1385 cases were collected from laboratory information system(LIS) and all the strain isolated from the same period the inpatients specimens. Bacterium identification and antimicrobial susceptibility test were performed using ATB Expression system, and analysis of different specimens and years popular strain and drug resistance spectrum were performed using Excel perspective chart. Results In recent five years, Staphylococcus aureus and pseudomonas aeruginosa were the predominant pathogen of nosocomial infection, but Acinetobacter baumanii has been increasing trend. In secretion，blood and indwelling needles the predominant pathogen were staphylococcus aureus，and escherichia coli and pseudomonas aeruginosa in urine and sputum, respectively. The susceptibility of pseudomonas aeruginosa from different specimens to same antimicrobial was significantly different. The drug-resistance of Pseudomonas aeruginosa separated from sputum on meropenem，imipenem,ticarcillin,piperacillin,ticarcillin-clavulani cacid, piperacillin-tazobactam, ceftazidime were higher than that separated from secretion. Conclusion Staphylococcus aureus and Pseudomonas aeruginosa were the predominant pathogen of nosocomial infection. The drug-resistance of Pseudomonas aeruginosa separated from sputum on carbapenems,anti-pseudomonas,β-lactamase compound and Ⅲcephalosporin were higher than that separated from secretion.

参考文献/References:

[1]吕时铭.浙江省医院细菌耐药分析.浙江省医院细菌耐药检测年鉴(2008年版)[M].杭州:浙江大学出版社，2009:69-70.
[2]梁淑兰，邓伟航，陈伟标.金黄色葡萄球菌及铜绿假单胞菌的耐药变迁[J].检验医学与临床，2010，7(21):2352-2355.
[3]陶 智，王 艳，齐金海.医院感染金黄色葡萄球菌的耐药性探讨[J].中华医院感染学杂志，2010，20(17):2689-2690.
[4]孙瑞珍.重症监护病房的医院感染临床研究[J].东南国防医药，2008，10(1):13-15.
[5]荣新洲，王志伟，吴永恒，等.五年来烧伤创面菌群变化与耐药性分析[J].第一军医大学学报，1999，19(3):234-235.
[6]佟爱华，董 梅，匡铁吉.2006～2009年铜绿假单胞菌医院感染临床分布及耐药性变迁[J].现代生物医学进展，2010，10(12):2288-2292.
[7]王建锋，黄晓波，许 旺.158例痰铜绿假单胞菌5年耐药情况分析[J].宁夏医学杂志，2010，32(10):973-974.
[8]陈 洁，潘景业，王晓蓉，等.医院感染铜绿假单胞菌的耐药性变迁及临床对策[J].中华医院感染学杂志，2010，20(15):2311-2313.
[9]周秀珍，孙继梅，刘建华.连续十年铜绿假单胞菌对碳青霉烯类抗生素耐药率分析[J].中国全科医学，2010，13(13):1467-1469.
[10]曾 吉，和亚涛，王成宝.耐亚胺培南铜绿假单胞菌的耐药性分析[J].临床血液学杂志，2010，23(8):496-497.
[11]周 平,沈默,黄学忠，林 佩，等.烧伤患者静脉留置针检出金黄色葡萄球菌及耐药性分析[J].中华医院感染学杂志,2008，18(1):108-110.

相似文献/References:

[1]黄学忠,金彬彬,林佩佩,等.细菌耐药监测预警系统的设计与应用[J].医学研究与战创伤救治(原医学研究生学报),2012,14(04):301.
　HUANG Xue-zhong,JIN Bin-bin,LIN Pei-pei,et al.Design and application of monitoring and warning system of bacterial resistance[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(03):301.
[2]孙瑞珍,曹尉尉.泌尿道医院感染的病原菌分布 与耐药性分析[J].医学研究与战创伤救治(原医学研究生学报),2009,11(04):305.
　SUN Rui-zhen,CAO Wei-wei.Distribution and antibiotic-resistance of pathogens in urinary tract hospital infection[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(03):305.
[3]孙瑞珍.重症监护病房的医院感染临床研究[J].医学研究与战创伤救治(原医学研究生学报),2008,10(01):13.
　SUN Rui-zhen.A clinical study of hospital infection in intensive care unit[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(03):13.
[4]朱饮源,姚 军,李 曼.糖原合成酶激酶3β对卵巢癌紫杉醇耐药性的影响及机制研究[J].医学研究与战创伤救治(原医学研究生学报),2015,17(01):29.[doi:10.3969/j.issn.1672-271X.2015.01.009]
　ZHU Yin-yuan,YAO Jun,LI Man..The effects of GSK-3β on paclitaxel chemoresistance of ovarian cancer cells[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(03):29.[doi:10.3969/j.issn.1672-271X.2015.01.009]
[5]沈小玥,穆晓苏,徐晓莉,等.9例大面积烧伤合并吸入性气道损伤患者下呼吸道感染的预防与控制[J].医学研究与战创伤救治(原医学研究生学报),2016,18(02):113.[doi:10.3969/j.issn.1672-271X.2016.02.001]
　SHEN Xiao-yue,MU Xiao-su,XU Xiao-li,et al.The prevention and control of lower respiratory tract infection in 9 cases of patients with large area burn combined inhalation injury[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(03):113.[doi:10.3969/j.issn.1672-271X.2016.02.001]
[6]杨 婧,赵 斌,李晓红,等.术后颅内感染菌种分布、危险因素与结局分析[J].医学研究与战创伤救治(原医学研究生学报),2016,18(03):233.[doi:10.3969/j.issn.1672-271X.2016.03.003]
　YANG Jing,ZHAO Bin,LI Xiao-hong,et al.A study of typing ST11 of klebsiella pneumoniae producing carbapenemases by matrix-assisted laser desorption ionization-time of flight mass spectrometry[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2016,18(03):233.[doi:10.3969/j.issn.1672-271X.2016.03.003]
[7]郭利利,张葵.尿沉渣分析仪检测白细胞和细菌对尿路感染的筛查价值[J].医学研究与战创伤救治(原医学研究生学报),2017,19(03):234.[doi:10.3969/j.issn.1672-271X.2017.03.003]
　GUO Li-li,ZHANG Kui.The value of urine sediment analyzer in screening white blood cells and bacteria for urinary tractinfection[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2017,19(03):234.[doi:10.3969/j.issn.1672-271X.2017.03.003]
[8]张毅,彭玲玲,黄丽玲.广东某军队医院2019年多重耐药菌检出现状及耐药性分析[J].医学研究与战创伤救治(原医学研究生学报),2021,23(01):45.[doi:10.3969/j.issn.1672-271X.2021.01.001]
　ZHANG Yi,PENG Ling-ling,HUANG Li-ling.Analyze the distribution and drug susceptibility of multi-drug-resistant bacteria in patients admitted to a military hospital in Guangdong in 2019[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(03):45.[doi:10.3969/j.issn.1672-271X.2021.01.001]
[9]周建文,王德怀,李丹,等.烧伤创面病原菌分布和耐药性分析[J].医学研究与战创伤救治(原医学研究生学报),2021,23(03):276.[doi:10.3969/j.issn.1672-271X.2021.03.012]
　ZHOU Jian-wen,WANG De-huai,LI Dan,et al.Analysis of distribution and drug resistance of pathogens of burnpatients[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(03):276.[doi:10.3969/j.issn.1672-271X.2021.03.012]
[10]张迪,初晓玲,楼小伟,等.203株血培养病原菌的分布和耐药情况分析[J].医学研究与战创伤救治(原医学研究生学报),2014,16(04):416.[doi:10.3969/j.issn.1672-271X.2014.04.027]

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2011-05-20