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[1]王承峰,董文涛,任榕娜.影响局灶性发作癫痫患儿智力状况的危险因素分析[J].医学研究与战创伤救治(原医学研究生学报),2012,14(03):222-224.
　WANG Cheng-feng,DONG Wen-tao,REN Rong-na..Risk factors for intelligence quotient of children with focal seizures[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(03):222-224.
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影响局灶性发作癫痫患儿智力状况的危险因素分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第14卷
期数:
2012年03期
页码:
222-224
栏目:
出版日期:
2012-05-22

文章信息/Info

Title:
Risk factors for intelligence quotient of children with focal seizures
文章编号:
1672-271X(2012)03-0222-03
作者:
王承峰; 董文涛; 任榕娜
350025 福建福州，南京军区福州总医院全军儿科疾病诊治中心
Author(s):
WANG Cheng-feng; DONG Wen-tao; REN Rong-na.
Department of Pediatrics,Fuzhou General Hospital of Nanjing Military Command,Fuzhou,Fujian 350025，China
关键词:
儿童; 局灶性发作癫痫; 智力; 危险因素
Keywords:
children;  focal seizures epilepsy;  IQ;  risk factors
分类号:
R742.1
DOI:
-
文献标志码:
A
摘要:
目的 探讨影响局灶性癫痫患儿智力状况的独立危险因素。方法 89名癫痫患儿在2005年至2010年进行智商检测,并结合症候学、脑电图(EEG)、CT或MR等检查确定为局灶性发作类型及致痫灶部位，应用多因素Logistic回归分析，判断影响局灶性癫痫患儿智力状况的独立危险因素。结果 高达58.4％(52/89)的局灶性发作癫痫患儿有智能缺陷。多因素Logistic回归分析提示:发作频率(P=0.022；OR=3.807；95%CI=1.215~11.926)，MRI或CT检查(P=0.010；OR=5.035；95%CI=1.467~17.286)，用药种类(P＜0.01；OR=9.105；95%CI =2.639~31.408)为影响局灶性发作患儿智力状况的独立危险因素；病程、首发年龄、发作类型与致痫灶的位置等因素对局灶性发作患儿智力没有独立的预测作用。结论 局灶性发作癫痫患儿智能易受损伤。影像学异常、癫痫发作频繁、用药种类多的局灶性癫痫患儿智能更易受损，应针对相关因素采取必要措施以减轻智力受损。
Abstract:
Objective To investigate the risk factors of IQ in children with focal seizures.Methods IQ of 89 children were tested from 2005 to 2009.The type and epileptogenic area of the epilepsy were determined according to the results of symptoms,EEG,CT or MR.Multivariate Logistic regression analysis were used to determine risk factors of IQ.Results IQ testing showed that 58.4％ (52/89)of children with focal seizures epilepsy were IQ dysfunction.Multivariate logistic regression analysis find seizure frequency (P=0.022; odds ratio,OR=3.807; 95% confidence interval,95%CI=1.215-11.926)MRI or CT outcome (P=0.010; OR=5.035; 95%CI=1.467-17.286)and drugs numbers (P＜0.01; OR=9.105; 95%CI=2.639-31.408)were the independent risk factors for IQ of children with focal seizures.Age at epilepsy onset,epilepsy duration,seizure types,epileptogenic area were not independent risk factors for IQ.Conclusion IQ of children with focal seizures epilepsy are easily impaired.High seizure frequency,imaging abnormalities,more numbers of drugs indicate IQ more easily impaired of children with focal seizures.We should take the necessary measures to slow down the process of IQ decline according to the factors.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2012-05-20