|本期目录/Table of Contents|

[1]孙 标综述,李向阳校审.PIM与消化系统肿瘤[J].医学研究与战创伤救治(原医学研究生学报),2012,14(04):345-347.
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PIM与消化系统肿瘤()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第14卷
期数:
2012年04期
页码:
345-347
栏目:
综述
出版日期:
2012-07-20

文章信息/Info

Title:
-
文章编号:
1672-271X(2012)04-0345-03
作者:
孙 标综述; 李向阳校审
233200 江苏淮安，解放军82医院
Author(s):
-
关键词:
莫洛尼鼠白血病病毒前病毒整合基因; 肿瘤; 细胞凋亡; 细胞周期
Keywords:
-
分类号:
R735
DOI:
-
文献标志码:
A
摘要:
莫洛尼鼠白血病病毒前病毒整合基因(Proviral integration of moloney murine leukemia virus，PIM)是编码丝/苏氨酸激酶的一类原癌基因，其功能的上调与一些恶性肿瘤的发生、发展密切相关。现对PIM在消化系统肿瘤诊断、治疗、预后中的作用综述如下。
Abstract:
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参考文献/References:

[1]Mochizuki T,Kitanaka C,Noguchi K,et al.PIM-1 kinase stimulates c-Myc-mediated death signaling upstream of caspase-3 (CPP32)-like protease activation［J］.Oncogene,1997,15(12):1471-1480.
[2］Manning G,Whyte DB,Martinez R,et al.The protein kinase complement of the human genome［J］.Science，2002,298(5600):1912-1934.
[3］Bachmann M,Mry T.The serine/threonine kinase PIM-1［J］.Int J Biochem Cell Biol，2005，37(4):726-730.
[4］Mukaida N,Wang YY,Li YY.Roles of PIM-3,a novel survival kinase in tumorigenesis［J］.Cancer Sci，2011，102(8):1437-1442.
[5］Mochizuki T,Kitanaka C,Noguchi K,et al.Physical and functional interactions between PIM-1 kinase and Cdc25A phosphatase.Implications for the PIM-1-mediated activation of the c-Myc signaling pathway［J］.J Biol Chem，1999，274(26):18659-18666.
[6］Wang Z,Bhattacharya N,Mixter PF,et al.Phosphorylation of the cell cycle inhibitor p21Cip1/WAF1 by PIM-1 kinase［J］.Biochim Biophys Acta，2002，1593(1):45-55.
[7］Bachmann M,Hennemann H,Xing PX,et al.The oncogenic serine/threonine kinase PIM-1 phosphorylates and inhibits the activity of Cdc25C-associated kinase 1 (C-TAK1):a novel role for PIM-1 at the G2/M cell cycle checkpoint［J］.2004，279(46):48319-48328.
[8］Aho TL,Sandholm J,Peltola KJ,et al.PIM-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site［J］.FEBS Lett，2004，571(1-3):43-49.
[9］Xie Y,Xu K,Linn DE，et al.The 44-kDa PIM-1 kinase phosphorylates BCRP/ABCG2 and thereby promotes its multimerization and drug-resistant activity in human prostate cancer cells［J］.J Biol Chem，2008，283(6):3349-3356.
[10］Lilly M,Sandholm J,Cooper JJ.The PIM-1 serine kinase prolongs survival and inhibits apoptosis-related mitochondrial dysfunction in part through a bcl-2-dependent pathway［J］.Oncogene，1999，18(27):4022-4031.
[11］Liu HT,Wang N,Wang X,et al.Overexpression of PIM-1 is associated with poor prognosis in patients with esophageal squamous cell carcinoma［J］.J Surg Oncol，2010，102(6):683-688.
[12］Li S,Xi Y,Zhang H,et al.A pivotal role for PIM-1 kinase in esophageal squamous cell carcinoma involving cell apoptosis induced by reducing Akt phosphorylation［J］.Oncol Rep，2010，24(4):997-1004.
[13］寇 炜,赵 晋,吴 静，等.原癌基因PIM-3蛋白表达与食管癌术后生存的关系［J］.中国老年学杂志,2011,31(14):2647-2648.
[14］李玉华,邸允安.青年人胃癌52例临床分析［J］.东南国防医药,2007，9(2):124-125.
[15］Warnecke-Eberz U,Bollschweiler E,Drebber U,et al.Prognostic impact of protein overexpression of the proto-oncogene PIM-1 in gastric cancer［J］.Anticancer Res，2009，29(11):4451-4455.
[16］Zheng HC,Tsuneyama K,Takahashi H,et al.Aberrant PIM-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression［J］.J Cancer Res Clin Oncol，2008，134(4):481-488.
[17］胡志方,黄 缘,钟 琼，等.PIM-3异常表达在胃癌中的意义［J］.世界华人杂志，2008,16(31):3515-3518
[18］李 波,叶 田,李德华，等.正常肝组织和肝癌组织中PIM-2基因的表达［J］.中华肝病杂志,2008,16(12):950-951.
[19］Ren K,Duan W,Shi Y,et al.Ectopic over-expression of oncogene PIM-2 induce malignant transformation of nontumorous human liver cell line L02［J］.J Korean Med Sci，2010，25(7):1017-1023.
[20］Ren K,Zhang W,Shi Y,et al.PIM-2 activates API-5 to inhibit the apoptosis of hepatocellular carcinoma cells through NF-kappaB pathway［J］.Pathol Oncol Res，2010，16(2):229-237.
[21］Gong J,Wang J,Ren Ket al.Serine/threonine kinase PIM-2 promotes liver tumorigenesis induction through mediating survival and preventing apoptosis of liver cell［J］.J Surg Res,2009，153(1):17-22.
[22］Wu Y,Wang YY,Nakamoto Y，et al.Accelerated hepatocellular carcinoma development in mice expressing the PIM-3 transgene selectively in the liver［J］.Oncogene，2010，29(15):2228-2237.
[23］Fujii C,Nakamoto Y,Lu P,et al.Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines［J］.Int J Cancer，2005,114(2):209-218.
[24］邓 欢,刘亮明,张吉翔，等.原癌基因PIM-3的克隆及其对肝癌细胞凋亡的影响［J］.世界华人消化杂志,2006,14(23):2288-2293.
[25］Sass G,Klinger N,Sirma H,et al.Inhibition of experimental HCC growth in mice by use of the kinase inhibitor DMAT［J］.Int J Oncol，2011，39(2):433-442.
[26］Reiser-Erkan C,Erkan M,Pan Z,et al.Hypoxia-inducible proto-oncogene PIM-1 is a prognostic marker in pancreatic ductal adenocarcinoma［J］.Cancer Biol Ther，2008，7(9):1352-1359.
[27］Xu D,Allsop SA,Witherspoon SM,et al.The oncogenic kinase PIM-1 is modulated by K-Ras signaling and mediates transformed growth and radioresistance in human pancreatic ductal adenocarcinoma cells［J］.Carcinogenesis，2011，32(4):488-495.
[28］Li YY，Popivanova BK，Nagai Y，et al.PIM-3,a proto-oncogene with serine/threonine kinase activity,is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines［J］.Cancer Res，2006，66(13):6741-6747.
[29］Popivanova BK,Li YY,Zheng H，et al.Proto-oncogene,PIM-3 with serine/threonine kinase activity is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis［J］.Cancer Sci，2007，98(3):321-328.
[30］董 赟，冯一中，李 峰.应用组织芯片研究PIM-3、p-STAT3在胰腺癌中的表达及临床意义［J］.临床与实验病理学杂志,2008,24(3):291-295.
[31］Wang YY,Taniguchi T,Baba T，et al.Identification of a phenanthrene derivative as a potent anticancer drug with Pim kinase inhibitory activity［J］.Cancer Sci，2012，103(1):107-115.
[32］Li YY,Wang YY,Taniguchi T，et al.Identification of stemonamide synthetic intermediates as a novel potent anticancer drug with an apoptosis-inducing ability［J］.Int J Cancer，2010，127(2):474-484.
[33］简 捷,胡志方,黄 缘，等.直肠腺癌中原癌基因Pim-3及其蛋白表达的研究［J］.中华消化杂志,2009,29(4):279-281.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2012-07-20