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[1]林夏雯,李爱梅,施 鸣,等.部分胃癌PET-CT显像与HIF-1α等指标的相关分析[J].医学研究与战创伤救治(原医学研究生学报),2012,14(05):407-410.
　LIN Xia-wen,LI Ai-mei,SHI Ming,et al.Analysis of relationship among HIF-1α,COX-2,VEGF and SUVmax in gastric cancer[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(05):407-410.
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部分胃癌PET-CT显像与HIF-1α等指标的相关分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第14卷
期数:
2012年05期
页码:
407-410
栏目:
出版日期:
2012-09-20

文章信息/Info

Title:
Analysis of relationship among HIF-1α,COX-2,VEGF and SUVmax in gastric cancer
文章编号:
1672-271X(2012)05-0407-04
作者:
林夏雯; 李爱梅; 施 鸣; 许守林; 郭万华
210008 江苏南京，鼓楼医院核医学科
Author(s):
LIN Xia-wen; LI Ai-mei; SHI Ming; XU Shou-lin; GUO Wan-hua
Nuclear Medicine Department of Nanjing Drum Tower Hospital,Nanjing,Jiangsu 210008,China
关键词:
胃癌; 18F-氟代脱氧葡萄糖; 缺氧诱导因子-1α; 环氧合酶2; 血管内皮生长因子
Keywords:
gastric cancer;  18F-fluorodeoxyglucose;  HIF-1α;  COX-2;  VEGF
分类号:
R735.2
DOI:
-
文献标志码:
A
摘要:
目的 探讨胃癌正电子发射体层显像(PET-CT)中18F-氟代脱氧葡萄糖(18F-FDG)摄取水平与相应组织中缺氧诱导因子-1α(hypoxia inducible factor-1α，HIF-1α)、环氧合酶-2(cyclooxygenase-2，COX-2)和血管内皮生长因子(vascular endothelial growth factor，VEGF)表达的关系。方法 对14例胃癌患者术前进行PET-CT检查,测定肿瘤最大标准摄取值(standard uptake value，SUVmax )，并对手术切除标本进行病理检查，应用免疫组织化学法检测肿瘤组织HIF-1α、COX-2 和VEGF的表达，分析PET-CT的SUVmax与HIF-1α、COX-2 和VEGF表达的相关性。结果 SUVmax与HIF-1α、COX-2和VEGF表达的相关系数(r)分别为0.499、0.686、0.279，均呈正相关(P<0.05)。结论 胃癌组织HIF-1α、COX-2 和VEGF表达量越大，PET-CT显像中18F-FDG摄取越多，浓聚越明显。
Abstract:
Objective To study the relationship among the expression of hypoxia inducible factor-1α (HIF-1α),cyclooxygenase-2 (COX-2),vascular endothelial growth factor (VEGF) and 18F-fluorodeoxyglucose (18F-FDG) uptake of positron emission tomography (PET-CT) imaging in patients with gastric cancer.Methods From August 2010 to August 2011,14 patients with gastric cancer were examined by PET-CT.The maximum standard uptake values (SUVmax) were measured.Resected tumor samples were pathologically examined.The expression of HIF-1α,COX-2 and VEGF of 14 cases were graded semi-quantitatively by immunohistochemistry.Kendall correlation was analysed for HIF-1α,COX-2,VEGF with SUVmax.Results The correlation coefficient (r) for the SUVmax and HIF-1α,COX-2,VEGF expression were 0.499,0.686,0.279,were all positively related (P<0.05).Conclusion 18F-FDG uptake correlates with expression of HIF-1α,COX-2 and VEGF in patients with gastric cancer.

参考文献/References:

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备注/Memo

备注/Memo:
南京市卫生局重点项目(ZKX09019)
更新日期/Last Update: 2012-09-20