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[1]潘 涛,张 均,范国峰,等.低分子肝素预防脑出血后静脉血栓的安全性研究[J].医学研究与战创伤救治(原医学研究生学报),2012,14(06):517-519.
　PAN Tao,ZHANG Jun,FAN Guo-feng,et al.Safety of low molecular weight heparin for the prevention of venous thromboembolism after primary intracerebral haemorrhage[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(06):517-519.
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低分子肝素预防脑出血后静脉血栓的安全性研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第14卷
期数:
2012年06期
页码:
517-519
栏目:
出版日期:
2012-11-20

文章信息/Info

Title:
Safety of low molecular weight heparin for the prevention of venous thromboembolism after primary intracerebral haemorrhage
文章编号:
1672-271X(2012)06-0517-03
作者:
潘 涛; 张 均; 范国峰; 张 龙; 顾双双
210008 江苏南京，南京大学医学院附属鼓楼医院急诊中心
Author(s):
PAN Tao; ZHANG Jun; FAN Guo-feng; ZHANG Long; GU Shuang-shuang.
Department of Emergency，Nanjing Drum Tower Hospital，the Affiliated Hospital of Nanjing University Medical School，Nanjing，Jiangsu 210008，China
关键词:
低分子肝素; 静脉血栓栓塞; 脑出血
Keywords:
low molecular weight heparin;  venous thromboembolism;  intracerebral hemorrhage
分类号:
R743.32
DOI:
-
文献标志码:
A
摘要:
目的 探讨脑出血患者抗凝预防静脉血栓栓塞时颅内血肿体积变化及相关安全性。方法 回顾性分析脑出血或脑出血合并脑室出血的患者，均在入院7 d内予以注射低分子肝素，并在用药7 d后复查头颅CT。计算患者低分子肝素治疗前后CT 上的颅内血肿体积的变化，血肿体积的计算使用ABC/2 法，脑室出血量的计算使用手绘出血区域方法。结果 共入选64 例，平均年龄65岁，美国国立卫生研究院卒中量表(NIHSS)评分中位值为10.6，基线时血肿体积平均为(24.3±22.3)ml，低分子肝素治疗前后CT 检查上的颅内血肿体积变化为(-4.35±10.5)ml，仅有1例的血肿体积增大。经分析，自发性脑出血患者发病7 d内给予低分子肝素预防深静脉血栓并不导致颅内血肿的增大。结论 在脑出血伴/不伴脑室出血的急性期，给予皮下注射低分子肝素预防静脉血栓栓塞不导致颅内血肿的增大。
Abstract:
Objective To observe the hematoma volume in patients with ICH before and after pharmacological deep venous thrombosis prophylaxis.Methods We identified patients from our hospital who presented with ICH only or ICH with intraventricular hemorrhage and received low molecular weight heparin subcutaneously within 7 days of admission and had a repeat CT scan performed after 7 days of starting venous thromboembolism prophylaxis.We calculated the change in hematoma volume from the admission and post-treatment CTs.Hematoma volume was calculated using the ABC/2 method and intraventricular hemorrhage volumes were calculated using the hand drawn regions of interest.Results We identified 64 patients with a mean age of 65 years and median National Institutes of Health Stroke Scale score 10.6.The mean baseline total hematoma volume was (24.3±22.3) ml.There was an change in hematoma volume from pre- and post-treatment CT of (-4.35±10.5) ml.One patients developed hematoma growth.Repeat analysis of patients given pharmacological deep venous thrombosis prophylaxis within 7days after ICH found no increase in hematoma size.Conclusion Pharmacological deep venous thrombosis prophylaxis given subcutaneously in patients with ICH and/or intraventricular hemorrhage in the acute period is generally not associated with hematoma growth.

参考文献/References:

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2012-11-20