|本期目录/Table of Contents|

[1]赵 伟,胡新国,王润兰.肌萎缩侧索硬化患者低密度脂蛋白的氧化敏感性[J].医学研究与战创伤救治(原医学研究生学报),2012,14(06):523.
　ZHAO Wei,HU Xin-guo,WANG Run-lan.Oxidized sensibility of low-density lipoproteins in patients with amyotrophic lateral sclerosis[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2012,14(06):523.
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肌萎缩侧索硬化患者低密度脂蛋白的氧化敏感性()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第14卷
期数:
2012年06期
页码:
523
栏目:
出版日期:
2012-11-20

文章信息/Info

Title:
Oxidized sensibility of low-density lipoproteins in patients with amyotrophic lateral sclerosis
文章编号:
1672-271X(2012)06-0523-03
作者:
赵 伟; 胡新国; 王润兰
332000 江西九江，南京军区庐山疗养院神经内科
Author(s):
ZHAO Wei; HU Xin-guo; WANG Run-lan
Department of Neurology,Lusan Sanatorium of Nanjing Military Command,Jiujiang,Jiangxi 332000,China
关键词:
肌萎缩侧索硬化; 脂蛋白类; 低密度脂蛋白
Keywords:
amyotrophic lateral sclerosis;  lipoproteins;  low-density lipoprotein
分类号:
R746.4
DOI:
-
文献标志码:
A
摘要:
目的 测定肌萎缩侧索硬化(ALS)患者血中低密度脂蛋白(LDL)体外氧化延迟时间的变化。方法 根据EL Escorial诊断标准选取ALS 19例，其中男15例，女4例，并与19例年龄、影响因素等相当的健康成人相对照。以铜氧化共轭双烯法测定血中LDL体外氧化延迟时间。结果 ALS组血中LDL体外氧化延迟时间较对照组明显减低，分别为(59.32±8.65)min 与(83.16±8.37)min，差异有统计学意义(P<0.05)。结论 增高的氧化压力与降低的抗氧化能力在ALS的发病机制中具有一定的作用，提示有效的抗氧化治疗可能对控制疾病的发展及改善预后具有一定的临床意义。
Abstract:
Objective To measure the changes in oxidized low-density lipoprotein (ox-LDL) lag time in patients with amyotrophic lateral sclerosis (ALS).Methods A case-control study was performed involving 15 male patients and 4 women with ALS diagnosed according to the Escorial criteria.19 age-matched healthy persons with comparable status of smoking and life style were used as control.For each subject,LDL oxidizability was measured by determining LDL oxidation lag time in conjugated diene product at 234 nm using Cu-stimulated oxidation.Results Compared to the levels in the control subjects,the ALS patients showed significantly reduced LDL oxidation lag time [(59.32±8.65) vs (83.16±8.37)min,P<0.05].Conclusion Decreased anti-oxidant ability are implicated in the mechanisms of ALS,suggesting the value of appropriate antioxidant therapy in controlling the progression of ALS．

参考文献/References:

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相似文献/References:

[1]赖福生,卢少军,王一芳,等.脐带血有核细胞移植治疗肌萎缩侧索硬化的临床研究[J].医学研究与战创伤救治(原医学研究生学报),2010,12(06):515.
　LAI Fu-sheng,LU Shao-jun,WANG Yi-fang,et al.Clinical study of treating amyotrophic lateral sclerosis with transplantation of umbilical cord blood nuclear cells[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(06):515.
[2]蔡少甫,郑庆亦,胡安根,等.高密度脂蛋白对严重烫伤大鼠肾功能的 保护作用[J].医学研究与战创伤救治(原医学研究生学报),2008,10(03):164.
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[3]蔡少甫,郑庆亦,郭毅斌,等.严重烧伤患者血脂变化与感染关系的研究[J].医学研究与战创伤救治(原医学研究生学报),2008,10(04):274.
　CAI Shao-fu,ZHENG Qing-yi,GUO Yi-bin,et al.The study of serum lipids changes in patients with severe burns and its relations with infectious complications[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(06):274.

备注/Memo

备注/Memo:
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更新日期/Last Update: 2012-11-20