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[1]过 伟,巴华杰,杨 春,等.Penta D、Penta E基因座与军人被动攻击行为关联的病例对照研究[J].医学研究与战创伤救治(原医学研究生学报),2013,15(03):224-227,243.[doi:10.3969/j.issn.1672-271X.2013.03.006]
　GUO Wei,BA Hua-jie,YANG Chun,et al.Case-control study of association between Penta D,Penta E loci with passive aggressive behaviors of armymen[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2013,15(03):224-227,243.[doi:10.3969/j.issn.1672-271X.2013.03.006]
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Penta D、Penta E基因座与军人被动攻击行为关联的病例对照研究()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第15卷
期数:
2013年03期
页码:
224-227,243
栏目:
出版日期:
2013-03-30

文章信息/Info

Title:
Case-control study of association between Penta D,Penta E loci with passive aggressive behaviors of armymen
作者:
过 伟1; 巴华杰2; 杨 春1; 余海鹰1; 赵汉清1; 高志勤1
1.213003 江苏常州,解放军102医院; 2.213003 江苏常州,常州市公安局刑警支队DNA实验室
Author(s):
GUO Wei1; BA Hua-jie2; YANG Chun1; YU Hai-ying1; ZHAO Han-qing1; GAO Zhi-qin1
1.102 Hospital of PLA,Changzhou,Jiangsu 213003,China; 2.DNA Laboratory of the Bureau of Changzhou Public Security,Changzhou,Jiangsu 213003,China
关键词:
军人; 被动攻击行为; 短串联重复序列; 遗传多态性; 病例对照研究
Keywords:
armymen;  passive-aggressive behavior;  short tandem repeats(STRs);  genetic polymorphism;  case-control studies
分类号:
R349.64
DOI:
10.3969/j.issn.1672-271X.2013.03.006
文献标志码:
A
摘要:
目的 探讨军人被动攻击行为与Penta D、Penta E基因座的关联情况。方法 采用PCR结合毛细管电泳的方法对178例男性军人被动攻击行为者(研究组)和459例健康男性(对照组)的外周静脉血样进行Penta D、Penta E基因座的基因型分析,观察两组在Penta D、Penta E基因座的等位基因及基因型分布差异。结果 Penta D、Penta E基因座均符合遗传平衡定律(Hardy-Weinberg定律); Penta E基因座等位基因及基因型频率在两个群体中分布差异有统计学意义(P<0.05); 在两个群体中Penta E基因座的基因型16-18的频率分布差异有统计学意义(P<0.01,OR:6.564,95%CI:2.278～18.914); Penta D基因座等位基因频率及基因型频率在两个群体中分布无显著差异(P>0.05)。结论 Penta E基因座多态性与军人被动攻击行为的发生存在关联,Penta E基因座基因型16-18为军人被动攻击行为的遗传易感因素。
Abstract:
Objective To investigate the relationship between the passive aggressive behavior of armymen and Penta D and Penta E loci.Methods PCR and electrophoresis method were used to conduct genetype analysis on Penta D and Penta E in the peripheral blood of 178 passive-aggressive violent offenders of armymen and 459 healthy men.Results Penta D and Penta E loci in armymen with passive-aggressive behavior and healthy group were found to coincide with Hardy-Weinberg equilibrium(P>0.05).There was a significant difference in locus Penta E(P<0.05)between both groups,not on locus Penta D(P>0.05).There was significant differences at genotype 16-18 on locus Penta E between the two groups(P<0.01),with the OR values being 6.564(95%CI:2.278 to 18.914).Conclusion Locus Penta E might be associated with passive-aggressive behavior of armymen,with genotype 18-19 being the genetic susceptible factor.

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备注/Memo

备注/Memo:
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更新日期/Last Update: 2013-05-20