|本期目录/Table of Contents|

[1]胡 晓,王 省,闫福岭,等.帕金森病患者便秘发生情况的临床观察[J].医学研究与战创伤救治(原医学研究生学报),2013,15(04):332-334.[doi:10.3969/j.issn.1672-271X.2013.04.004]
　HU Xiao,WANG Xing,YAN Fu-ling,et al.Clinic investigation of constipation in Parkinson's disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2013,15(04):332-334.[doi:10.3969/j.issn.1672-271X.2013.04.004]
点击复制

帕金森病患者便秘发生情况的临床观察()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第15卷
期数:
2013年04期
页码:
332-334
栏目:
出版日期:
2013-08-05

文章信息/Info

Title:
Clinic investigation of constipation in Parkinson's disease
作者:
胡 晓1; 王 省2; 闫福岭1; 刘卫国3
1.210009 江苏南京,东南大学附属中大医院神经内科(胡晓现在南京安宁医院); 2.210028 江苏南京,江苏省中西医结合医院神经内科; 3.210029 江苏南京,南京医科大学附属脑科医院神经内科
Author(s):
HU Xiao1; WANG Xing2; YAN Fu-ling1; LIU Wei-guo3
1.Department of Neurology,Affiliated Zhongda Hospital of Southeast University,Nanjing,Jiangsu 210009,China; 2.Department of Neurology,Jiangsu Province Hospital on Integration of Chinese and Western Medicine,Nanjing,Jiangsu 210028,China; 3.Department of Neurology,Affiliated Nanjing Brain Hospital of Nanjing Medical University,Nanjing,Jiangsu 210029,China
关键词:
帕金森病;  便秘;  相关因素
Keywords:
Parkinsons disease;  constipation;  correlation factors
分类号:
R742.5; R256.35
DOI:
10.3969/j.issn.1672-271X.2013.04.004
文献标志码:
A
摘要:
目的 观察帕金森病(Parkinsons disease,PD)患者便秘的发生率,探讨便秘发生的相关因素。方法 观察219例PD患者便秘的发生率; 所有患者均完成了简易智能精神状态检查量表(MMSE)、Hoehn-Yahr分期和统一帕金森病评分量表第三部分(UPDRS Ⅲ)、罗马Ⅲ标准的评估及抗帕金森病药物左旋多巴等效剂量(LED)的换算。分析PD患者便秘发生的相关因素。 结果 219例PD患者中, 便秘发生率为69.41%(152/219),PD患者服用抗帕金森病药物LED和UPDRS Ⅲ评分与便秘发生显著相关,相关系数(r)分别为0.186、0.195(P<0.01)。结论 便秘是PD患者的常见症状,PD患者运动障碍症状重、服用抗PD药物剂量大是其危险因素。
Abstract:
Objective To investigate the prevalence and correlation factors of constipation in Parkinsons disease.Methods We used mini-mental state examination(MMSE),Hoehn-Yahr staging,Unified Parkinson Disease Rating Scale(UPDRS)part Ⅲ,RomeⅢ standard assess 219 PD patients.The Levodopa equivalent doses(LED)of PD patients were calculated.Results 152 PD patients exist constipation,the prevalence of constipation in Parkinsons disease was 69.41%(152/219),and correlation factors of LED and UPDRS Ⅲ scores were 0.186 and 0.195 respectively(P<0.01).Conclusion Constipation is a common symptom in PD patients.The more severe motor symptom and higher LED is the risk factors in prevalence of constipation in Parkinsons disease.

参考文献/References:

[1] Mandel JS,Adami HO,Cole P.Paraquat and Parkinsons disease:an overview of the epidemiology and a review of two recent studies[J].Regul Toxicol Pharmacol,2012,62(2):385-392.
[2] Chaudhuri KR,Healy DG,Schapira AH.Non-motor symptoms of Parkinsons disease:diagnosis and management[J].Lancet Neurol,2006,5(3):235-245.
[3] Jost WH.Gastrointestinal dysfunction in Parkinsons Disease[J].J Neurol Sci,2010,289(1-2):69-73.
[4] Salawu FK,Danburam A,Olokoba AB.Non-motor symptoms of Parkinsons disease:diagnosis and management[J].Niger J Med,2010,19(2):126-131.
[5] Gage H,Kaye J,Kimber A,et al.Correlates of constipation in people with Parkinsons disease[J].Parkinsonism Relat Disord,2011,17(2):106-111.
[6] Gibb WR,Lees AJ.The relevance of the Lewy body to the pathogenesis of idiopathic Parkinsons disease[J].J Neurol Neurosurg Psychiatry,1988,51(6):745-752.
[7] Tomlinson CL,Stowe R,Patel S,et al.Systematic review of levodopa dose equivalency reporting in Parkinsons disease[J].Mov Disord,2010,25(15):2649-2653.
[8] Bharucha AE,Wald A,Enck P,et al.Functional anorectal disorders[J].Gastroenterology,2006,130(5):1510-1518.
[9] Kaye J,Gage H,Kimber A,et al.Excess burden of constipation in Parkinsons disease:a pilot study[J].Mov Disord,2006,21(8):1270-1273.
[10] 吴志彬,李秀增,余 涛,等.7341名疗养员新发生疾病的分析[J].东南国防医药,2011,13(2):155-156.
[11] Blandini F,Balestra B,Levandis G,et al.Functional and neurochemical changes of the gastrointestinal tract in a rodent model of Parkinsons disease[J].Neurosci Lett,2009,467(3):203-207.
[12] Kuo YM,Li Z,Jiao Y,et al.Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated alpha-synuclein gene mutations precede central nervous system changes[J].Hum Mol Genet,2010,19(9):1633-1650.
[13] Lebouvier T,Neunlist M,Bruley des Varannes S,et al.Colonic biopsies to assess the neuropathology of Parkinsons disease and its relationship with symptoms[J].PLoS One,2010,5(9):e12728.
[14] Hawkes CH,Del Tredici K,Braak H.A timeline for Parkinsons disease[J].Parkinsonism Relat Disord,2010,16(2):79-84.
[15] Tateno F,Sakakibara R,Yokoi Y,et al.Levodopa ameliorated anorectal constipation in de novo Parkinsons disease:the QL-GAT study[J].Parkinsonism Relat Disord,2011,17(9):662-666.
[16] Muller B,Assmus J,Larsen JP,et al.Autonomic symptoms and dopaminergic treatment in de novo Parkinsons disease[J].Acta Neurol Scand,2012,127(4):290-294.
[17] Li ZS,Schmauss C,Cuenca A,et al.Physiological modulation of intestinal motility by enteric dopaminergic neurons and the D2 receptor:analysis of dopamine receptor expression,location,development,and function in wild-type and knock-out mice[J].J Neurosci,2006,26(10):2798-2807.

相似文献/References:

[1]于苏文,郑秀琴,陈红霞,等.高频重复经颅磁刺激治疗帕金森病临床疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2010,12(02):109.
　YU Su-wen,ZHENG Xiu-qin,CHEN Hong-xia,et al.Clinicalal study of treating Parkinsons disease by repetitively transcranial magnetic stimulation[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2010,12(04):109.
[2]曾 志,张国兴,陈基敏.代谢热层像诊断帕金森病5例报告[J].医学研究与战创伤救治(原医学研究生学报),2008,10(01):6.
[3]余志阳,潘士勇,刘清珍,等.丙泊酚对帕金森小鼠黑质多巴胺能神经元凋亡的影响[J].医学研究与战创伤救治(原医学研究生学报),2015,17(04):346.[doi:10.3969/j.issn.1672-271X.2015.04.003]
　YU Zhi-yang,PAN Shi-Yong,LIU Qing-zhen,et al.The effect of propofol on apoptosis of dopaminergic neurons in the substantia nigra of mouse model of Parkinson’s disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2015,17(04):346.[doi:10.3969/j.issn.1672-271X.2015.04.003]
[4]张扬,管得宁,徐运.跌倒恐惧对帕金森病患者生活质量的影响[J].医学研究与战创伤救治(原医学研究生学报),2018,20(01):6.[doi:10.3969/j.issn.1672-271X.2018.01.002]
　ZHANG Yang,GUAN De-ning,XU Yun.Impact of fear of falling on quality of life in patients with Parkinson′s disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2018,20(04):6.[doi:10.3969/j.issn.1672-271X.2018.01.002]
[5]周元,任兴珍,郭安娜.不同干预时机对神经外科急诊患者排便及腹压的影响[J].医学研究与战创伤救治(原医学研究生学报),2019,21(6):655.[doi:10.3969/j.issn.1672-271X.2019.06.023]
[6]杨雅玲,刘华斌,林庆金.枸橼酸坦度螺酮治疗帕金森病异动症的疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2021,23(02):146.[doi:10.3969/j.issn.1672-271X.2021.02.008]
　YANG Ya-ling,LIU Hua-bin,LIN Qing-jin.Therapeutic effect of tandorone citrate on Parkinson’s disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(04):146.[doi:10.3969/j.issn.1672-271X.2021.02.008]
[7]戴为正,吴美娜,傅懋林,等.普拉克索联合高频重复经颅磁刺激治疗早期帕金森病合并抑郁患者的临床疗效观察[J].医学研究与战创伤救治(原医学研究生学报),2021,23(6):592.[doi:10.3969/j.issn.1672-271X.2021.06.007]
　DAI Wei-zheng,WU Mei-na,FU Mao-lin,et al.Observation on clinical effects of pramipexole combined with high-frequency repetitive transcranial magnetic stimulation (rTMS) in the treatment of patients suffered from early Parkinson’s disease (PD) and depression[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2021,23(04):592.[doi:10.3969/j.issn.1672-271X.2021.06.007]

备注/Memo

备注/Memo:
基金项目: 国家自然科学基金资助项目(81170309); 江苏省中医药管理局资助项目(LB09088); 南京市科技局资助项目(200905016)
更新日期/Last Update: 2013-08-05