|本期目录/Table of Contents|

[1]杨仁荣,曹金林,刘桂宝,等.甲泼尼龙对急性肺损伤后血清IL-6、IL-8和TNF-α水平的影响及临床意义[J].医学研究与战创伤救治(原医学研究生学报),2013,15(04):338-339,348.[doi:10.3969/j.issn.1672-271X.2013.04.006]
　YANG Ren-rong,CAO Jin-lin,LIU Gui-bao,et al.The clinical effect of methylprednisolone on serum IL-6,IL-8 and TNF-α after acute lung injury[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2013,15(04):338-339,348.[doi:10.3969/j.issn.1672-271X.2013.04.006]
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甲泼尼龙对急性肺损伤后血清IL-6、IL-8和TNF-α水平的影响及临床意义()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第15卷
期数:
2013年04期
页码:
338-339,348
栏目:
出版日期:
2013-08-05

文章信息/Info

Title:
The clinical effect of methylprednisolone on serum IL-6,IL-8 and TNF-α after acute lung injury
作者:
杨仁荣; 曹金林; 刘桂宝; 郑海燕; 陶进新; 史智杰; 施建国
310004 浙江杭州,解放军117医院胸外科
Author(s):
YANG Ren-rong; CAO Jin-lin; LIU Gui-bao; ZHENG Hai-yan; TAO Jin-xin; SHI Zhi-jie; SHI Jian-guo
Department of Thoracic Surgery,117 Hospital of PLA,Hangzhou,Zhejiang 310004,China
关键词:
炎症因子;  糖皮质激素;  肺损伤;  急救
Keywords:
inflammatory cytokines;  methylprednisolone;  lung injury;  first aid
分类号:
R563.1
DOI:
10.3969/j.issn.1672-271X.2013.04.006
文献标志码:
A
摘要:
目的 探讨甲泼尼龙对急性肺损伤后血清IL-6、IL-8和TNF-α水平的影响及临床意义。方法 对2010 年1月-2012 年11月收治的伤后2h内入院的急性肺损伤25例,抽取伤后2 h、4 h、8 h、12 h、24 h、48 h、72 h血液,对血清IL-6、IL-8和TNF-α水平进行检测,16例经早期、小剂量、短期内应用甲泼尼龙治疗[入院即开始予以静脉滴注甲泼尼龙2 mg/(kg·d),3 d后再逐渐减量至伤后7 d停用,激素组],9例未应用甲泼尼龙及其他激素类药物治疗(对照组),检测比较各水平的变化。结果 IL-6、IL-8在肺损伤后48 h达高峰,TNF-α在肺损伤后24 h达高峰,激素组上述各炎症指标在肺损伤12 h开始显著低于对照组(P<0.05)。结论 急性肺损伤与血清IL-6、IL-8和TNF-α有关,早期、小剂量、短期内应用甲泼尼龙有助于减少炎性递质释放,改善因炎症性反应而引起的肺换气功能障碍,防止肺进一步损伤,有利于患者早日康复。
Abstract:
Objective To investigate the clinical effect of methylprednisolone on serum IL-6,IL-8 and TNF-α after acute lung injury.Methods From January 2010 to November 2012,25 patients were admitted to our hospital within 2 hours after acute lung injury,whose blood was extracted in 2 h,6 h,12 h,24 h,48 h,72 h after trauma,serum IL-6,IL-8 and TNF-α were detected by enzyme-linked immunosorbent assay(ELISA).Early,low-dose and short-term therapy was applied with methylprednisolone in 16 cases(we began to infusion methylprednisolone of 2 mg/(kg·d)by intravenous after admission,3 days later,the dose of methylprednisolone gradually reduced until 7 days,hormone group),and another nine cases,methylprednisolone and other hormonal drugs werent applied(control group).The change of serum IL-6,IL-8 and TNF-α were compared.Results IL-6,IL-8 reached the peak at 48 hours after lung injury,but TNF-α reached a peak at 24 hours.The inflammatory cytokines in hormone group were extraordinary lower than control group after 12 h in lung injury(P<0.05).Conclusion Acute lung injury has a relation with serum IL-6,IL-8 and TNF-α.Early,low-dose and short-term application of methylprednisolone will help to reduce the inflammatory mediators release,improve the lung ventilation dysfunction which caused by inflammatory reaction,prevent the further damage of lung,and conducive to patient recovery.

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备注/Memo

备注/Memo:
基金项目: 全军医药卫生科研攻关基金课题(08G097)
更新日期/Last Update: 2013-08-05