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[1]黎茂尧,梁 芳,朱军艺,等.假性甲状旁腺功能减退症12例诊治分析[J].医学研究与战创伤救治(原医学研究生学报),2014,16(02):166-167，206.[doi:10.3969/j.issn.1672-271X.2014.02.017]
　LI Mao-yao,LAING Fang,ZHU Jun-yi,et al.Diagnosis and treatment of pseudo hypoparathyroidism(12 cases report)[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(02):166-167，206.[doi:10.3969/j.issn.1672-271X.2014.02.017]
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假性甲状旁腺功能减退症12例诊治分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年02期
页码:
166-167，206
栏目:
出版日期:
2014-03-20

文章信息/Info

Title:
Diagnosis and treatment of pseudo hypoparathyroidism(12 cases report)
作者:
黎茂尧; 梁 芳; 朱军艺; 毛冰凌
525100 广东化州，广东省化州市人民医院内一科
Author(s):
LI Mao-yao; LAING Fang; ZHU Jun-yi; MAO Bing-ling.
The First Medical Department of People’s Hospital in Huazhou City,Huazhou,Guangdong 525100,China
关键词:
假性甲状旁腺功能减退症; 临床症状; 误诊分析
Keywords:
pseudo hypoparathyroidism; clinical symptoms; misdiagnosis analysis
分类号:
R582.2
DOI:
10.3969/j.issn.1672-271X.2014.02.017
文献标志码:
A
摘要:
目的 研究并探讨假性甲状旁腺功能减退症的临床特点、诊断及临床治疗情况。方法 对2002年3月-2012年3月12例假性甲状旁腺功能减退症(PHP)的临床诊治资料进行回顾 分析。结果 本组患者男女比例为1∶2，发病年龄(22.5±8.6)岁；所有患者的血钙、尿钙、血镁以及尿磷比正常人低，甲状旁腺素(PTH)、血磷、骨碱性磷酸酶(BALP)比正常人高； 较为常见的临床症状为手足抽搐10例、癫痫样发作7例、肢端麻木5例；3例合并遗传性骨营养不良；2例合并甲状腺功能减退；所有患者均行颅脑CT检查，其中10例发现颅内钙化； 病症误诊5例，主要误诊为缺钙、原发性癫痫及脑膜炎后遗症。结论 假性甲状旁腺功能减退症发病患者多为儿童，临床诊断易被误诊为原发性癫痫。为了降低临床误诊率，临床医 生应该注意低钙血症的临床表现。假性甲状旁腺功能减退症主要采用钙剂联合维生素D或是其衍生物进行治疗。对于同时合并甲状腺功能减退的患者应同时给予相应治疗。
Abstract:
Objective To investigate the clinical characteristics,diagnosis and clinical treatment of pseudo hypoparathyroidism.Methods 12 cases with pseudo hypoparathyroidism in our hospital from March 2002 to March 2012 were retrospectively analyzed.Results The male/female ratio was 1∶2,and the average age was (22.5±8.6) years in 12 cases.The urinary calcium，urinary calcium and blood magnesium phosphate levels in patients was lower than that of healthy people.PTH,phosphorus,BALP level were higher than that of healthy people.The mainly clinical symptoms were tetany (10 cases),epileptic seizures (7 cases),limb numbness (5 cases).3 cases were combined with hereditary osteodystrophy.2 cases were combined with thyroid dysfunction.All patients were detected by brain CT examination,and 10 cases were detected with intracranial calcifications.5 cases were misdiagnosed,mainly misdiagnosed as calcium deficiency,idiopathic epilepsy and meningitis sequelae.Conclusion The pseudo hypoparathyroidism patients were mostly children,which was easily misdiagnosed as epilepsy.To reduce the misdiagnosis rate,clinical manifestations should be paid more attention.Pseudo hypoparathyroidism could be effective treated by calcium combined with vitamin D or its derivatives.For patients with concomitant hypothyroidism should be given appropriate treatment.

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更新日期/Last Update: 2014-03-20