|本期目录/Table of Contents|

[1]杨环文,陈育霞,丁红兵,等.抗病毒治疗对慢性乙型肝炎患者肝组织病理的影响[J].医学研究与战创伤救治(原医学研究生学报),2014,16(04):391-393.[doi:10.3969/j.issn.1672-271X.2014.04.018]
　YANG Huan-wen,CHEN Yu-xia,DING Hong-bing,et al.The effect of antiviral therapy on liver histology in chronic hepatitis B patients[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(04):391-393.[doi:10.3969/j.issn.1672-271X.2014.04.018]
点击复制

抗病毒治疗对慢性乙型肝炎患者肝组织病理的影响()
分享到62.8K

《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年04期
页码:
391-393
栏目:
出版日期:
2014-07-31

文章信息/Info

Title:
The effect of antiviral therapy on liver histology in chronic hepatitis B patients
作者:
杨环文; 陈育霞; 丁红兵; 曾龙; 刘小龙
362000 福建泉州,解放军180医院肝病中心
Author(s):
YANG Huan-wen; CHEN Yu-xia; DING Hong-bing; ZENG Long; LIU Xiao-long．
Clinical Liver Diseases Research Center,180 Hospital of PLA，Quanzhou,Fujian 362000，China
关键词:
慢性乙型肝炎; 抗病毒; 肝组织病理检查; 病毒学完全应答
Keywords:
chronic hepatitis B;  antiviral therapy;  liver histology;  virological response
分类号:
R512.62
DOI:
10.3969/j.issn.1672-271X.2014.04.018
文献标志码:
A
摘要:
目的 通过对慢性乙型肝炎患者抗病毒治疗前后进行肝组织病理检查，分析其抗病毒治疗效果。方法 收集2005年8月-2012年10月治疗的慢性乙型肝炎29例，在其抗病毒治疗48周前后进行肝穿刺活检检查，比较治疗前后变化。结果 与治疗前相比，完全应答组无论炎症或纤维化程度均明显改善(P＜0.01)，部分应答组炎症程度得到改善(P＜0.05)，纤维化程度则无明显改变(P＞0.05),而无应答组治疗前后相比，炎症及纤维化程度均无明显改变(P＞0.05)。结论 无论予干扰素或核苷(酸)类似物抗病毒治疗，获得病毒学完全应答均可明显改善肝脏炎症、纤维化程度。
Abstract:
Objective To evaluate the efficacy of antiviral therapy in chronic hepatitis B (CHB) patients by histologically examination of liver before and after therapy.Methods 29 CHB patients between August 2005 and October 2012 were received biopsy before and after antiviral treatment of 48 weeks,and the histological improvement was evaluated.Results Compared with pretreatment,both inflammation grade and fibrosis stage were significantly improved in complete response group(P＜0.01).Through compared with pretreatment,only inflammation grade in part-response group were improved significantly(P＜0.05),and fibrosis stage was no obvious change(P＞0.05).There was no obvious change of inflammation grade and fibrosis stage in non-response group(P＞0.05).Conclusion CHB patients treated with interferon or nucleoside analogues (acid) achieved virological complete response and can greatly improve the degree of liver inflammation and fibrosis.

参考文献/References:

[1]Dusheiko G.Treatment of HBeAg positive chronic hepatitis B:interferon or nucleoside analogues[J].Liver Int,2013,33(Suppl 1):137-150.
[2]Leung N.Treatment of HBeAg-positive chronic hepatitis B with nucleos(t)ide analogues[J].Liver Int,2011,31(Suppl 1):85-89.
[3]中华医学会肝病学分会，中华医学会传染病分会.慢性乙型肝炎防治指南(2010年版)[J].实用肝脏病杂志,2011,14(2):83-84.
[4]曾德民，王泰龄，王宝恩.肝纤维化诊断与疗效评估共识[J].诊断性理论与实践,2002,1(3):191-192.
[5]王泰龄.慢性肝炎炎症活动度及纤维化程度计分方案[J].中华肝脏病杂志,1998,12(6):195-196.
[6]McMahon BJ.Chronic hepatitis B virus infection[J].Med Clin North Am,2014，98(1):39-54.
[7]de Franchis R,Hadengue A,Lau G,et al.Proceedings of the European Association for the Study of the Liver (EASL) International Consensus Conference on Hepatitis B.September 14-16,2002.Geneva,Switzerland[J].J Hepatol,2003,39(Suppl 1):S1-235.
[8]Yang HI,Lu SN,Liaw YF,et al.Hepatitis B e antigen and the risk of hepatocellularcarcinoma[J].N Engl J Med,2002,347(3):168-174.
[9]庄 辉.我国乙型肝炎病毒感染与挑战[J].中华传染病杂志,2005,23(增刊):2-6.
[10]Chen CJ，Yang HI.Natural history of chronic hepatitis B REVEALed[J].J Gastroenterol Hepatol，2011,26(4):628-638.
[11]Jafri SM,Lok AS.Antiviral therapy for chronic hepatitis B[J].Clin Liver Dis,2010,14(3):425-438.
[12]Chen LP,Zhao J,Du Y,et.al.Antiviral treatment to prevent chronic hepatitis B or C-related hepatocellular carcinoma[J].World J Virol,2012,1(6):174-183.
[13]Tziomalos K.Effect of antiviral treatment on the risk of hepatocellular carcinoma in patients with chronic hepatitis B[J].World J Hepatol,2010,2(3):91-93.
[14]马 飞.慢性乙肝治疗亟需强效药物抗病毒[N].医药经济报,2013-7-22(8).

相似文献/References:

[1]周岳进.妊娠期妇女慢性乙型肝炎患者核苷(酸)类似物抗病毒治疗[J].医学研究与战创伤救治(原医学研究生学报),2013,15(03):279.[doi:10.3969/j.issn.1672-271X.2013.03.023]
[2]俞加勇,吴晓燕综述,朱方石审校.中药抗HBV的临床研究进展[J].医学研究与战创伤救治(原医学研究生学报),2010,12(01):45.
[3]郑瑞丹,张闽峰,孟家榕,等.HBeAg阴性慢性乙型肝炎并非酒精性 脂肪性肝病56例临床及病理特征[J].医学研究与战创伤救治(原医学研究生学报),2009,11(01):10.
　ZHENG Rui-dan,ZHANG Min-feng,MENG Jia-rong,et al.Study on clinical and pathological characteristic in HBeAg negative chronic hepatitis B patients with nonalcoholic fatty liver disease[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2009,11(04):10.
[4]汪茂荣.解读《2008亚太肝病研究学会慢性 乙型肝炎防治指南》[J].医学研究与战创伤救治(原医学研究生学报),2008,10(04):241.

备注/Memo

备注/Memo:
-
更新日期/Last Update: 2014-07-20