|本期目录/Table of Contents|

[1]赵娜娜,李 娜,蒋 平.胺碘酮联合阿托伐他汀钙与单用胺碘酮治疗房颤的Meta分析[J].医学研究与战创伤救治(原医学研究生学报),2014,16(06):587-591.[doi:10.3969/j.issn.1672-271X.2014.06.009]
　ZHAO Na-na,LI Na,JIANG Ping..Meta analysis of the effect of amiodarone combined with atorvastatin calcium and single use of amiodarone in treatment of atrial fibrillation[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2014,16(06):587-591.[doi:10.3969/j.issn.1672-271X.2014.06.009]
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胺碘酮联合阿托伐他汀钙与单用胺碘酮治疗房颤的Meta分析()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年06期
页码:
587-591
栏目:
出版日期:
2014-11-20

文章信息/Info

Title:
Meta analysis of the effect of amiodarone combined with atorvastatin calcium and single use of amiodarone in treatment of atrial fibrillation
作者:
赵娜娜; 李 娜; 蒋 平
221004 江苏徐州，解放军97医院药剂科
Author(s):
ZHAO Na-na; LI Na; JIANG Ping.
Department of Pharmacy,97 Hospital of PLA,Xuzhou,Jiangsu 221004,China
关键词:
胺碘酮; 阿托伐他汀钙; 心房颤动;  Meta分析
Keywords:
amiodarone;  atorvastatin calcium;  atrial fibrillation;  meta analysis
分类号:
R541.75
DOI:
10.3969/j.issn.1672-271X.2014.06.009
文献标志码:
A
摘要:
目的 系统评价胺碘酮联合阿托伐他汀钙与单用胺碘酮治疗房颤的临床疗效和对患者血清CRP、左房内径的影响。方法 检索PubMed、Elsvier、CNKI数据库2000-2012年的 所有文献，尽可能全面地收集相关临床试验资料，并在严格评价文献质量的基础上，利用RevMan5.0进行Meta分析。用Mantel-Haensze法对其结果进行检验并证实其同质性，若具有 同质性则选择固定效应模型，否则选择随机效应模型。用漏斗图分析文献的发表偏倚。结果 10个胺碘酮联合阿托伐他汀钙治疗房颤窦性心律维持情况的分析研究具有同质性 (P=0.96，I2=0%)，选择固定效应模型分析，OR=2.42,95%CI(1.75,3.35)。6个胺碘酮联合阿托伐他汀钙治疗房颤CRP水平变化的分析研究不具有同质性(P=0.006，I2=69%)，选择随 机效应模型分析，OR=-1.60,95%CI(-1.97,-1.23)。结论 胺碘酮联合阿托伐他汀钙比单用胺碘酮能更有效地降低CRP的水平，更好地维持窦性心律，在治疗前后左房内径的改变和不 良反应发生率方面两组间差异无统计学意义(P>0.05)。
Abstract:
Objective To evaluate the clinical efficacy of amiodarone combined with atorvastatin calcium and single use of amiodarone in treatment of atrial fibrillation and the effect of serum CRP,left atrial diameter.Methods Retrieved from PubMed,Elsvier,CNKI during 2000 to 2012,as comprehensively as possible to collect the relevant data from clinical trials,meta analysis was performed by RevMan5.0 on the basis of strict evaluation of literature quality; the results were tested and confirmed whether they have the homogeneity by Mantel-Haensze method,if have the homogeneity,which allowed to use the fixed effect model analysis,otherwise use the random effect model analysis; publication bias was analyzed by funnel plots.Results 10 analyses of amiodarone combined with atorvastatin calcium in the treatment of atrial fibrillation to sinus rhythm maintenance situation have the homogeneity (P=0.96,I2=0%),use the fixed effect model analysis,OR=2.42,95%CI (1.75,3.35).6 analyses of amiodarone combined with atorvastatin calcium in the treatment of atrial fibrillation CRP levels do not have the homogeneity (P=0.006,I2=69%),use the random effect model analysis,OR=-1.60,95%CI (-1.97,-1.23).Conclusion Amiodarone combined with atorvastatin calcium can more effectively reduce the level of CRP and better maintenance of sinus rhythm than single use of amiodarone,the two groups of the left atrial diameter changes before and after the treatment and ADR are not statistically different(P>0.05).

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相似文献/References:

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　ZHUANG Cong-wen,WENG Xiang-qun,CHENG Xian-jin,et al.Analysis of amiodarone therapy for supraventricular arrhythmias after operation in patients with lung cancer[J].JOURNAL OF MEDICALRESEARCH —COMBAT TRAUMA CARE,2008,10(06):252.

备注/Memo

备注/Memo:
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更新日期/Last Update: 2014-11-20