|本期目录/Table of Contents|

[1]黄迎娣,崔 蕾,黄利鸣综述,等.上皮间质转化与肿瘤耐药[J].医学研究与战创伤救治(原医学研究生学报),2014,16(06):624-628.[doi:10.3969/j.issn.1672-271X.2014.06.020]
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上皮间质转化与肿瘤耐药()
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《医学研究与战创伤救治》（原医学研究生学报）[ISSN:1672-271X/CN:32-1713/R]

卷:
第16卷
期数:
2014年06期
页码:
624-628
栏目:
综述
出版日期:
2014-11-20

文章信息/Info

Title:
-
作者:
黄迎娣; 崔 蕾; 黄利鸣综述; 王艳林审校
443002 湖北宜昌，三峡大学医学院分子生物学研究所
Author(s):
-
关键词:
上皮间质转化; 肿瘤; 化疗; 耐药; 信号通路
Keywords:
-
分类号:
R730.5
DOI:
10.3969/j.issn.1672-271X.2014.06.020
文献标志码:
B
摘要:
化疗是恶性肿瘤最常用的治疗手段之一，但肿瘤发生获得性耐药是阻碍临床疗效，导致大多数患者治疗失败的主要原因。近年来大量研究发现，肿瘤细胞上皮间质转化 (epithelial to mesenchymal transition，EMT)不仅促进肿瘤细胞的侵袭和转移，也在多种肿瘤发生化疗耐药中发挥重要作用。肿瘤细胞EMT的发生受复杂的信号通路调控，这些 信号通路也在诱导肿瘤细胞耐药中起重要作用。本文综述了肿瘤细胞发生EMT与耐药相关机制的研究进展。
Abstract:
-

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备注/Memo

备注/Memo:
国家自然科学基金项目(81374024)；湖北省自然科学基金项目(2013CFA079)
更新日期/Last Update: 2014-11-20